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Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tran Tat Thang Pham Hong phuong nguyen Sa Huynh nguyen Trung Kien nguyenDuy Toan nguyen Thi Thu ha Le ha Khoa nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye Hospital Nghe An 43000Vietnam Nghe An Friendship General Hospital Nghe An 43000Vietnam Military Hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam hanoi Medical University Ha Noi 100000Vietnam Bạch Mai Hospital Ha Noi 100000Vietnam TTH Vinh General Hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scoreshan in the control group(41.7%versus 18.8%;Phan those without DE,P<*** age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<***:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

Comparative Chemical Research in Essential Oils from Six Apiaceae Species Growing in the Northern Region of Vietnam

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1677-1687页

作者： nguyen Quang Hung nguyen Thanh Tung nguyen phuong hanh Chu Thi Thu ha nguyen Thi Nhung nguyen Thai An Vu Xuan Giang Luong Van hao Oleh Koshovyi Ain Raal Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Department of Pharmacognosy Faculty of Pharmacognosy and Traditional MedicineHanoi University of PharmacyHoan KiemHa Noi100000Viet Nam Sa Pa Research Center of Medicinal Materials National Institute of Medicinal MaterialsDien Bien PhuSa PaLao Cai330000Viet Nam Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia

Our study aimed to compare the essential oil(EO)concentration and composition of several Apiaceae species growing in the Northern region of *** yields of EOs from materials ranged from 0.03%(root EO of Angelica acutiloba and aerial parts EO of Heracleum bivittatum)-0.27%(leaf EO of Xyloselinum vietnamense).Gas chromatography-mass spectrometry(GC-MS)allowed the identiﬁcation of 74 components in the EOs of six Apiaceae species,making up 94.4%–100.0%of the *** EO from Angelica acutiloba,(Z)-ligustilide accounted for an extremely large proportion(94.9%).EO of Angelica pubescens was dominated by six character-istic components includingα-pinene(21.5%),β-phellandrene(18.1%),p-cymene(12.2%),3-methylnonane(8.7%),o-cymene(8.1%),and D-sylvestrene(6.2%).The EO from Cryptotaenia japonica was characterized by high amounts ofα-selinene(48.7%),β-selinene(23.7%),and trans-β-farnesene(5.4%).The EOs from leaves and stems of Xyloselinum vietnamense were characterized by high concentrations of sabinene(69.8%and 33.8%),4-terpineol(8.7%and 7.4%)andβ-pinene(4.0%and 6.5%)while EOs from aerial parts and root of Xylo-selinum leonidii comprise four characteristic monoterpenes includingα-pinene(28.2%and 52.8%),β-pinene(7.9%and 10.3%),β-phellandrene(7.6%and 15.3%),and sabinene(3.0%and 4.1%).Additionally,cryptone is also one of the major components in the EO of Xyloselinum leonidii(13.2%in the aerial parts oil and 2.8%in the root oil).In the EOs isolated from the aerial parts and root of Heracleum bivittatum,α-pinene(22.5%and 70.2%)andβ-pinene(43.2%and 20.0%)were the predominant *** appeared in the EO from aerial parts of Heracleum bivittatum with a relatively high concentration(13.5%)while bornyl acetate(5.1%)was also one of the main components in the EO from its aerial parts but was not detected in other Apiaceae species in the present *** databases help identify and control the quality of plant material studied from the family Apiaceae growing in Vietnam.

关键词： Apiaceae essential oil terpenoids gaschromatography-mass spectrometry

Effectiveness of bee venom acupuncture for patients suffering from periarthritis humeroscapularis

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中医杂志:英文版 2023年第4期43卷 795-800页

作者： Minh Duc nguyen Thanh Van Tran Quoc Vinh nguyen Cay Doan ha Linh Vu phuong Dang Senior Specialist Clinic National Hospital of AcupunctureHanoi 1000Vietnam Department of Senior Specialist National Hospital of Acupuncture Hanoi 1000Vietnam Department of Senior Specialist Military Institute of Traditional MedicineHanoi 1000Vietnam Department of minimally invasive spine National Hospital of AcupunctureHanoi 1000Vietnam Department of Medicine Dai Nam UniversityHanoi 1000Vietnam

OBJECTIVE:To evaluate the efficacy of bee venom acupuncture in humeroscapularis(PHS)***:One hundred and twenty patients diagnosed with PHS were assigned into four groups:BV1(0.01 mg/kg),BV2(0.005 mg/kg),BV3(0.0025 mg/kg),and control group(vitamin B1 plus novocain 3%injection)with 15 d of *** outcomes of the study including visual analogue scale(VAS)score andβ-endorphin,inflammatory cytokines including interleukin-10(IL-10),IL-1βand tumor necrosis factorα(TNF-α)and shoulder function score were assessed at baseline,after 10 and 15 d of ***:All four groups reported statistically significant improvement in VAS score,motion range,and shoulder function score(Phan current therapy used in Vietnam and other groups.

关键词： periarthritis humeroscapularis bee venom acupuncture visual analogue scale range of motion articular shoulder function score inflammatory cytokines

Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation-associated genes

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 553-560页

作者： Huyen T.T.nguyen Minh T.H.nguyen Thu X.nguyen Quan M.Pham ha X.nguyen phuong T.M.nguyen University of Science and Technology of hanoi Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and TechnologyHanoiVietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:To investigate the osteoblastogenic activity of the ethyl acetate(EtOAc)extract of Smilax glabra Roxb roots and its major active compound ***:Astilbin was isolated from EtOAc extract using silica gel chromatography combined with fraction *** structure of astilbin was determined by analysis of the spectroscopic data in comparison with the *** method was used to detect the *** phosphatase(ALP)activity was determined by the spectrophotometric method at 405 nm using p-nitrophenyl phosphate as a *** deposition was stained with alizarin red-S,distained with cetylpyridium chloride,and quantified at 562 *** silico model for astilbin-ALP interaction was analyzed using AutoDock *** changes in expression of osteoblast differentiation related genes were determined using quantitative real-time ***:Both the EtOAc extract and astilbin had no toxicity toward osteoblast MC3T3-E1 cells at 5.0,10,25,and 50μg/*** 25μg/mL,they enhanced ALP activity and mineralization of osteoblasts up to 30%and 55%for the EtOAc extract and 22%and 41%for astilbin,*** docking analysis of astilbin-ALP interaction revealed Arg167,Asp320,His324,and His437 were key residues participating in hydrophobic interaction;meanwhile,His434 and Thr436 residues were involved in hydrogen bond formation in the active site of human tissue-nonspecific ***,the expression level of genes opn,col1,osx,and runx2 were up-regulated in astilbin treated samples with the fold changes as 2.2;3.7;4.1;2.3,respectively at 10μg/mL(P<0.05).Conclusions:The EtOAc extract and its major compound astilbin exhibit osteoblastogenic activity by up-regulating important markers for bone cell *** could be a new and promising osteogenic agent with dual actions for therapeutic applications.

关键词： Smilax glabra Roxb Astilbin Cytotoxicity Osteogenesis Osteoblast Ethyl acetate extract

Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do Thi Thanh phuong Ngo Thi Hien nguyen Thi Thu Nga nguyen Thi Hung Le Ngoc Thao DoThi ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam hanoi Open University101 nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(Phanol extract, particularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralpha, interleukin-6, and interleukin-10 in treated ***: Polygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and PGE2 inhibition in an experimental mouse model with collagen antibody-induced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2

Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： ha Thi phuong Tran Thu Huong Le Thi Vinh Hoang Thi Khuyen Do Thi Thao nguyen Thanh Huong Pham Thi Lien Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths

A Data Collection on Secondary School Students’STEM Performance and Reading Practices in an Emerging Country

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Data Intelligence 2021年第2期3卷 336-356页

作者： Quan-Hoang Vuong Viet-phuong La Manh-Toan Ho Thanh-hang Pham Thu-Trang Vuong ha-My Vuong Minh-Hoang nguyen Centre for Interdisciplinary Social Research Phenikaa UniversityYen Nghia WardHa Dong DistrictHanoi 100803Vietnam A.I.for Social Data Lab Vuong&AssociatesDong Da DistrictHanoi 100000Vietnam School of Business and Management RMIT Vietnam UniversityHanoi 100000Vietnam

Science,technology,engineering,and mathematics(STEM)education has become a critical factor in promoting sustainable ***,book reading is still an essential method for cognitive development and knowledge *** developing countries where STEM teaching and learning resources are limited,book reading is an important educational tool to promote ***,public data sets about STEM education and book reading behaviors in emerging countries are *** article,therefore,aims to present a data set of 4,966 secondary school students from a school-based data collection in *** data set comprises of five major categories:1)students’personal information(including STEM performance),2)family-related information,3)book reading preferences,4)book reading frequency/habits,and 5)classroom *** introducing the designing principles,the data collection method,and the variables in the data set,we aim to provide researchers,policymakers,and educators with well-validated resources and guidelines to conduct low-cost research,pedagogical programs in emerging countries.

关键词： STEM education Socio-economic status Book reading Emerging country Students

Evaluation of Weathering Performance of Rosin-Copper Based Treated Wood

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Journal of Renewable Materials 2022年第11期10卷 2765-2780页

作者： Thi Thanh Hien nguyen Nho Quyet Tran Thi Minh Nguyet nguyen Hien Mai Trinh Xuan phuong Le Trong Kien nguyen College of Wood Industry and Interior Design Vietnam National University of ForestryHa NoiViet Nam College of Economics and Management Northeast Forestry UniversityHarbinChina

This study aimed to evaluate the effect of natural weathering on some surface characteristics and mechanical properties of Styrax wood treated with mixtures of 1.0%,2.0%,or 4.0%rosin sizing agent and 3%copper *** samples after treatment were exposed to outdoor conditions for one year and changes in color,glossiness,weight loss,compression strength parallel to grain(CSPG),modulus of rupture(MOR),and modulus of elasticity(MOE)were investigated after 6 and 12-month of natural *** results showed that rosin-copper treatment could improve color stability and gloss of samples after *** losses of all rosin-copper treated samples after 12 months of exposure were negligible compared with the untreated control *** addition,rosin-copper treatment enhanced the CSPG compared to untreated controls,but slightly decreased the MOR and MOE of Styrax wood before *** weathering factors induced a reduction for all strength properties,however,the decrease rate for strength properties of rosin-copper treated samples was negligible compared with the untreated control samples after 12-month natural weathering *** FTIR and SEM-EDX confirmed that the use of the rosin-copper formulations to impregnate wood could decrease the hazard of the copper preservative leaching into the environment,while also enhancing more resistance against weathering factors and other biotic factors.

关键词： Rosin-copper weathering color stability CSPG MOR MOE

A Multinational Data Set of Game Players' Behaviors in a Virtual World and Environmental Perceptions

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Data Intelligence 2021年第4期3卷 606-629页

作者： Quan-Hoang Vuong Manh-Toan Ho Viet-phuong La Tam-Tri Le Thanh Huyen T.nguyen Minh-Hoang nguyen Centre for Interdisciplinary Social Research Phenikaa UniversityYen Nghia WardHa Dong DistrictHanoi 100803Vietnam A.I.for Social Data Lab Vuong&AssociatesDong Da DistrictHanoi 100000Vietnam

Video gaming has been rising rapidly to become one of the primary entertainment media,especially during the COVID-19 *** video games has been reported to associate with many psychological and behavioral ***,little is known about the connections between game players’behaviors in the virtual environment and environmental ***,the current data set offers valuable resources regarding environmental worldviews and behaviors in the virtual world of 640 Animal Crossing:New Horizons(ACNH)game players from 29 countries around the *** data set consists of six major categories:1)socio-demographic profile,2)COVID-19 concern,3)environmental perception,4)gameplaying habit,5)in-game behavior,and 6)game-playing *** making this data set open,we aim to provide policymakers,game producers,and researchers with valuable resources for understanding the interactions between behaviors in the virtual world and environmental perceptions,which could help produce video games in compliance with the United Nations(UN)Sustainable Development Goals.

关键词： Environmental psychology Virtual environment Game-playing behaviors Multinational UN compliance design