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Radical-mediated hydroalkylation of 2-vinylpyrrolidine derivatives: a versatile entry into indolizidine alkaloids

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Science China Chemistry 2019年第11期62卷 1504-1506页

作者： Sankar Rao Suravarapu Bettina Peter philippe renaud Department of Chemistry and Biochemistry University of Bern

A concise route for the preparation of two simple optically pure indolizidin-5-ones has been *** key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected *** using complementary strategies,these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5)and their conversion to a variety of indolizidine alkaloids such as coniceine,indolizidine 209D and 167B,5-epi-indolizidine 249A and monomorine has been reported in the literature.

关键词： alkenes carbohydrogenation radical reaction catechol triethylborane α-iodoesters allylamine

Nanovolcano microelectrode arrays: toward long- term on-demand registration of transmembrane action potentials by controlled electroporation

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Microsystems & Nanoengineering 2020年第1期6卷 578-589页

作者： Benoit X.E.Desbiolles Etienne de Coulon Nicolas Maino Arnaud Bertsch Stephan Rohr philippe renaud Laboratory of Microsystems LMIS4 Ecole Polytechnique Federale de LausanneLausanneSwitzerland Department of Physiology Laboratory of Cellular Optics IIUniversity of BernBernSwitzerland

Volcano-shaped microelectrodes(nanovolcanoes)functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular *** nanovolcanoes exhibit recording characteristics similar to those of state-of-the-art micro-nanoelectrode arrays that use electroporation as an insertion *** this study,we investigated whether the use of electroporation improves the performance of nanovolcano arrays in terms of action potential amplitudes,recording durations,and *** with neonatal rat cardiomyocyte monolayers grown on nanovolcano arrays demonstrated that electroporation pulses with characteristics derived from analytical models increased the efficiency of nanovolcano recordings,as they enabled multiple on-demand registration of intracellular action potentials with amplitudes as high as 62 mV and parallel recordings in up to~76%of the available *** performance of nanovolcanoes showed no dependence on the presence of functionalized nanopatterns,indicating that the tip geometry itself is instrumental for establishing a tight seal at the cell–electrode interface,which ultimately determines the quality of ***,the use of electroporation permitted the recording of attenuated cardiomyocyte action potentials during consecutive days at identical sites,indicating that nanovolcano recordings are nondestructive and permit long-term on-demand recordings from excitable cardiac *** from demonstrating that less complex manufacturing processes can be used for next-generation nanovolcano arrays,the finding that the devices are suitable for performing on-demand recordings of electrical activity from multiple sites of excitable cardiac tissues over extended periods of time opens the possibility of using the devices not only in basic research but also in the context of comprehensive drug testing.

关键词： arrays recording action

Tunnel junctions in a III-V nanowire by surface engineering

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Nano Research 2015年第3期8卷 980-989页

作者： Salman Nadar Chloe Rolland Jean-Frangois Lampin Xavier Wallart philippe Caroff renaud Leturcq Institute of Electronics Microelectronics and Nanotechnology CNRS-UMR 8520 ISEN Department Avenue Poincare CS 60069 59652 Villeneuve d'Ascq Cedex France Department of Electronic Materials Engineering Research School of Physics and Engineering The Australian National University Canberra ACT0200 Australia Departement Science et Analyse des Mat~riaux Centre de Recherche Public-Gabriel Lippmann 41 rue du Brill L-4422 Belvaux Luxembourg

We demonstrate a simple way of fabricating high performance tunnel devices from p-doped InAs nanowires by tailoring the n-doped surface accumulation layer inherent to InAs surfaces. By using appropriate ammonium sulfide based surface passivation before metallization without any further thermal treatment, we demonstrate characteristics of tunnel p-n junctions, namely Esaki and backward diodes, with figures of merit better than previously published for InAs homojunctions. The further optimization of both the surface doping, in a quantitative way, and the device geometry allows us to demonstrate that these nanowire-based technologically-simple diodes have promising direct current characteristics for integrated high frequency detection or generation.

关键词： semiconductor nanowire tunnel junction indium arsenidecompounds doping Ⅲ-Ⅴ semiconductors

Graphite Nanoplatelets Composite Materials: Role of the Epoxy-System in the Thermal Conductivity

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Journal of Materials Science and Chemical Engineering 2015年第5期3卷 75-87页

作者： Lurayni Diaz-Chacon renaud Metz philippe Dieudonné Jean Louis Bantignies Said Tahir Mehrdad Hassanzadeh Eleida Sosa Reinaldo Atencio Laboratorio de Materiales para Tecnologías Emergentes Centro de Investigación en Tecnología de los Materiales Instituto Venezolano de Investigaciones Científicas Maracaibo Venezuela Laboratoire Charles Coulomb (L2C) UMR 5221 CNRS-Université de Montpellier Montpellier Université Lyon 1 Lyon France Materials and Solid Insulation Architect-Energy BU/Medium Voltage Switchgear Schneider Electric Grenoble France

Polymers typically have intrinsic thermal conductivity much lower than other materials. Enhancement of this property may be obtained by the addition of conductive fillers. In this research, epoxy nanocomposites with exfoliated graphite nanoplatelets are prepared and characterized. The chosen approach requires no surface treatment and no sophisticated equipments allowing one to produce composites on a pilot scale. A significant increase of the thermal conductivity with the increasing of the graphite fillers content is nevertheless observed on 4 mm thick specimens. Our results viewed in the latest scientific findings suggest that the choice of resin is an important parameter to move towards composite materials with high thermal conductivity.

关键词： Composite Epoxy-GnP Thermal Conductivity Graphite Nanoplatelets Exfoliated Graphite

French Validation of the Screen for Cognitive Impairment in Psychiatry (SCIP-F)

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Open Journal of Psychiatry 2016年第1期6卷 107-118页

作者： Smadar Valérie Tourjman Miriam H. Beauchamp Akram Djouini Mathilde Neugot-Cerioli Charlotte Gagner philippe Baruch Serge Beaulieu Florence Chanut Andrée Daigneault Robert-Paul Juster Sonia Montmayeur Stéphane Potvin Scot Purdon Suzanne renaud Evens Villenneuve Institut Universitaire en Santé Mentale de Montréal Montreal Canada Centre de Recherche de l’H?pital Ste-Justine Montreal Canada Institut Universitaire en Santé Mentale de Québec Quebec Canada Douglas Mental Health University Institute Montreal Canada Centre Hospitalier Universitaire de Montréal Montreal Canada Faculté de Pharmacie d’Angers Université Angers Angers France Department of Psychiatry University of Alberta Edmonton Canada

Background: Measuring cognition in clinical practice is clearly essential to the appropriate characterisation of patients’ clinical status and to the development of a personalised care plan. The Screen for Cognitive Impairment in Psychiatry (SCIP) has been developed in order to provide a brief and accessible tool allowing the evaluation of cognitive function in psychiatric conditions. Objective: We present a validation of a French version of the SCIP. Method: Translation from English into French is carried out using the accepted back-translation method. Seventy-two healthy volunteers are characterised by demographic questionnaires and a neuropsychological battery. The French version of the SCIP is then administered on two separate occasions separated by at least a one-week interval. Results: High internal consistencies as well as strong correlations with comparable neuropsychological tests are obtained. A normalised Cronbach’s α = 0.66 is obtained. Conclusions: The French version of the SCIP (SCIP-F) yields results comparable to the English version. The SCIP represents an essential tool for the preliminary evaluation of cognition. Its characteristics, brevity and the lack of need for a technological platform, allow for its integration into clinical practice. Further testing of SCIP-F in various psychiatric conditions will yield valuable information on its potential in clinical settings.

关键词： Screen for Cognitive Impairment in Psychiatry Cognitive Deficits Neuropsychological Assessment Cognitive Screening Patient-Centered Approaches