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Chemo-type of essential oil of Ocimum basilicum *** DR Congo and relative in vitro antioxidant potential to the polarity of crude extracts

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1022-1028页

作者： Dorothee Dinangayi Tshilanda philippe bila babady Damase Nguwo Vele Onyamboko Christian Muamba Tshilolo Tshiongo Damien Sha-Tshibey Tshibangu Koto-te-Nyiwa Ngbolua philippe Vuka Tsalu Pius Tshimankinda Mpiana Department of Chemistry Faculty of ScienceUniversity of Kinshasa bila Nutraceuticals Company Department of Biology Faculty of ScienceUniversity of Kinshasa

Objective:To carry out a phyto-chemical characterization of essential oil from Ocimum basilicum L.(***) harvested in DR Congo and to assess the antioxidant potential of crude extracts with respect to the polarity for comparison ***:The phyto-chemical characterization of essential oil produced by hydrodistillation was performed by coupled gas chromatography-mass spectrometer analysis and the antioxidant potential evaluation by in vitro 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity ***:A previously weighed amount of fresh leaves of *** produced 0.65%of essential oil that led to the identification of a set of 84.44%out of 99.98%as major compounds(> 1.5%).The chemo-type of this essential oil was linalool-methyl *** components of oil were characterized by oxygenated aromatic hydrocarbons(46.00%) and oxygenated monoterpenes(26.75%).With respect to the amount of components,methyl chavicol also known as estragole(35.72%) constituted the very large quantity afterward linalool(21.25%) and then epi-α-cadinol(8.02%),α-bergamotene(6.56%),eugenol(4.60%),1,8-cineole(4.04%),germacrene D(2.06%),thymol(1.64%),and(E)-citral(1.55%),*** oil exhibited antioxidant potential and IC_(50) =(1.180 ± 0.015) mg/***-polar crude extracts yields were low compared to the one of polar *** methanol and ethyl acetate had considerably manifested antioxidant potential with IC_(50) values equal to(0.025 ± 0.013) mg/mL and(0.085 ± 0.012) mg/mL,*** concerns to IC50 values,essential oil was less active than methanol and ethyl acetate *** methanol crude extract exhibited the highest ***-polar extracts showed insignificant radical scavenging ability that did not allow assessing IC50 *** results highlighted the occurrence of antioxidant potential compounds in polar ***:Essential oil and crude extracts of *** growing in DR Congo can be advocated as nat

关键词： Ocimum basilicum L. Essential oil Polar and non-polar crude extracts In vitro antioxidant potential GC-MS analysis

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Anti-sickling Activity of Ursolic Acid Isolated from the Leaves of Ocimum gratissimum L.(Lamiaceae)

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Natural Products and Bioprospecting 2015年第4期5卷 215-221页

作者： Dorothee Dinangayi Tshilanda Damase NguwoVele Onyamboko philippe babady-bila Koto-te-Nyiwa Ngbolua Damien ShaTshibey Tshibangu Eddy dia Fita Dibwe Pius Tshimankinda Mpiana Faculte des Sciences Universite de KinshasaB.P.190Kinshasa XIDemocratic Republic of the Congo bila Nutraceuticals Company 650 Portland Street MarketPO Box 26056DartmouthNS B2W 6P3Canada Institute of Natural Medicine University of Toyama2630-SugitaniToyama 930-0194Japan

The present study reports in vitro anti-sickling activity and phytochemical analyses of the leaves of Ocimum *** testing revealed that the plant extracts possess antisickling *** combination of spectroscopic techniques:1D-NMR,2D-NMR and MS revealed that ursolic acid is the major biologically active compound of ***(Silva et *** Molecules 13:2482–2487,2008;Kedar et al.J Food Drug Anal 20:865–871,2012).This study is the first report of the antisickling activity of ursolic acid isolated from *** pharmaceutical relevance of findings from this study derives from the possibility of integrating *** as an antisickling plant in the pharmacopoeia of Democratic Republic of the *** identification of the active principle could enhance the standardization of antisickling recipe.

关键词： Ocimum gratissimum Sickle cell disease Antisickling activity Ursolic acid

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Chemical Fingerprint and Anti-Sickling Activity of Rosmarinic Acid and Methanolic Extracts from Three Species of Ocimum from DR Congo

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Journal of Biosciences and Medicines 2016年第1期4卷 59-68页

作者： Dorothée D. Tshilanda Paulin K. Mutwale Damase V. N. Onyamboko philippe B. babady philippe V. Tsalu Damien S. T. Tshibangu Nadege K. Ngombe M. Frederich Koto-te-Nyiwa Ngbolua Pius T. Mpiana Department of Chemistry Faculty of Science University of Kinshasa Kinshasa Democratic Republic of the Congo Centre d’Etudes des Substances Naturelles d’Origine Végétale (CESNOV) Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of the Congo bila Nutraceuticals Company Dartmouth Canada Laboratory of Pharmacognosy Department of Pharmacy CIRM University of Liège CHU Liège Belgium Department of Biology Faculty of Science University of Kinshasa Kinshasa Democratic Republic of the Congo

The aim of this study was to characterize the polyphenolic composition by determination of chemical fingerprints of Methanolic extracts of Ocimum canum Sims, Ocimum basilicum L. and Ocimum gratissimum L. from Democratic Republic of Congo and to compare their antisickling activity of that of rosmarinic acid, the major compound to those of methanolic extracts. Phytochemical analysis performed by TLC and HPLC analysis, showed that rosmarinic acid is the most abundant phenolic acid in these Ocimum species according to the following order O. basilicum L., O. gratissimum L. and O. canum Sims. Methanolic extracts of these three species and pure rosmarinic acid showed significant antisickling activities with minimal concentration of normalization values of 0.18 ± 0.03, 0.23 ± 0.04, 0.26 ± 0.04 and 0.31 ± 0.05 mg/mL for rosmarinic acid, O. basilicum L., O. gratissimum L. and O. canum Sims methanolic extracts respectively. The antisickling activity order is the same as that of the rosmarinic acid content, indicating that this polyphenolic acid would be among the main active molecules in these extracts.

关键词： Antisickling Chemical Fingerprint O. canum O. basilicum O. gratissimum Rosmarinic Acid

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