Anti-sickling Activity of Ursolic Acid Isolated from the Leaves of Ocimum gratissimum L.(Lamiaceae)

作     者：Dorothee Dinangayi Tshilanda Damase NguwoVele Onyamboko Philippe Babady-Bila Koto-te-Nyiwa Ngbolua Damien ShaTshibey Tshibangu Eddy dia Fita Dibwe Pius Tshimankinda Mpiana 

作者机构：Faculte des SciencesUniversite de KinshasaB.P.190Kinshasa XIDemocratic Republic of the Congo Bila Nutraceuticals Company650 Portland Street MarketPO Box 26056DartmouthNS B2W 6P3Canada Institute of Natural MedicineUniversity of Toyama2630-SugitaniToyama 930-0194Japan 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2015年第5卷第4期

页      面：215-221页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Ocimum gratissimum Sickle cell disease Antisickling activity Ursolic acid 

摘      要：The present study reports in vitro anti-sickling activity and phytochemical analyses of the leaves of Ocimum *** testing revealed that the plant extracts possess antisickling *** combination of spectroscopic techniques:1D-NMR,2D-NMR and MS revealed that ursolic acid is the major biologically active compound of ***(Silva et *** Molecules 13:2482–2487,2008;Kedar et al.J Food Drug Anal 20:865–871,2012).This study is the first report of the antisickling activity of ursolic acid isolated from *** pharmaceutical relevance of findings from this study derives from the possibility of integrating *** as an antisickling plant in the pharmacopoeia of Democratic Republic of the *** identification of the active principle could enhance the standardization of antisickling recipe.