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Increased type III interferons and NK cell functions in SARS-CoV-2-infected children

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Signal Transduction and Targeted Therapy 2023年第3期8卷 888-890页

作者： Seong Dong Jeong Hoyoung Lee Ju Young Chang Seong Yong Lee Ji Eun Choi Eunmi Yang Hye Won Jeong Jae-phil Choi Mi Seon Han Eui-Cheol Shin The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)Daejeon 34126Republic of Korea Department of Pediatrics Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University of College of MedicineSeoul 07061Republic of Korea Division of infectious diseases Seoul Medical CenterSeoul 02053Republic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Republic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is more likely to progress to severe disease in the elderly,and the rates of hospitalization for coronavirus disease 2019(COVID-19)increase with age.1,2 Herein,we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2.

关键词： infected acute respiratory

No-reference image quality assessment based on AdaBoost_BP neural network in wavelet domain

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Journal of Systems Engineering and Electronics 2019年第2期30卷 223-237页

作者： YAN Junhua BAI Xuehan ZHANG Wanyi XIAO Yongqi CHATWIN Chris YOUNG Rupert BIRCH phil College of Astronautics Nanjing University of Aeronautics and Astronautics School of Engineering and Informatics University of Sussex

Considering the relatively poor robustness of quality scores for different types of distortion and the lack of mechanism for determining distortion types, a no-reference image quality assessment(NR-IQA) method based on the Ada Boost BP neural network in the wavelet domain(WABNN) is proposed. A 36-dimensional image feature vector is constructed by extracting natural scene statistics(NSS) features and local information entropy features of the distorted image wavelet sub-band coefficients in three scales. The ABNN classifier is obtained by learning the relationship between image features and distortion types. The ABNN scorer is obtained by learning the relationship between image features and image quality scores. A series of contrast experiments are carried out in the laboratory of image and video engineering(LIVE) database and TID2013 database. Experimental results show the high accuracy of the distinguishing distortion type, the high consistency with subjective scores and the high robustness of the method for distorted images. Experiment results also show the independence of the database and the relatively high operation efficiency of this method.

关键词： image quality assessment (IQA) AdaBoost_BP neural network (ABNN) wavelet transform natural scene statistics (NSS) local information entropy

Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2537-2552页

作者： Chitra Karki Amod Athavale Vijay Abilash Gary Hantsbarger Parnia Geransar Kate Lee Slobodan Milicevic Marko Perovic Leanne Raven Magdalena Sajak-Szczerba Abigail Silber Annabelle Yoon phil Tozer Global Evidence and Outcomes-Gastroenterology Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Trinity Partners LLCWalthamMA 02451-7528United States Observational Research Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Medical Affairs Takeda Pharmaceuticals International Co.Opfikon 8152ZurichSwitzerland Research and Patient Programs Crohn’s and Colitis Canada600-60 St.Clair Avenue EastToronto M4T 1N5OntarioCanada Treasurer European Federation of Crohn’s&Ulcerative Colitis AssociationsBrussels B 1000Belgium Crohn’s and Colitis Australia Camberwell SouthVIC 3124Australia European Federation of Crohn’s&Ulcerative Colitis Associations Brussels B 1000Belgium Japan Medical Office Takeda Pharmaceutical Company LimitedTokyo 103-8668Japan Department of Colorectal Surgery St Mark’s Hospital and Academic InstituteLondon HA13UJUnited Kingdom

BACKGROUND Patients with Crohn’s disease(CD)are at risk of developing complications such as perianal *** with Crohn’s perianal fistulas(CPF)are affected by fecal incontinence(FI),bleeding,pain,swelling,and purulent perianal discharge,and METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries(April-August 2021).Patients were recruited into three cohorts:Cohort 1 included patients without perianal fistulas;cohort 2 included patients with perianal fistulas without fistula-related surgery;and cohort 3 included patients with perianal fistulas and fistula-related *** patient-reported outcome measures were used to assess quality of *** of treatment preferences were measured using a discrete choice experiment(DCE).RESULTS In total,929 patients were recruited(cohort 1,n=620;cohort 2,n=174;cohort 3,n=135).Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF(cohorts 2 and 3)than for those with CD without CPF(cohort 1):Mean score 3.8 and 3.7 vs 4.1,respectively,(P<0.001).Similarly,mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without *** of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery(cohorts 2 and 3):Mean score 41 and 42,*** the DCE,postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice:Mean relative importance 35.7 and 24.7,*** The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.

关键词： Burden of illness Crohn’s disease Discrete choice experiment Perianal fistulas Patient-reported outcomes Treatment preferences

Conodont Biostratigraphy of Ordovician Deep-Water Turbiditic Sequences in Eastern Australia——A New Biozonal Scheme for the Open-Sea Realm

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Journal of Earth Science 2021年第3期32卷 486-500页

作者： Yong Yi Zhen Ian G.Percival phil Gilmore Jodie Rutledge Liann Deyssing W.B.Clarke Geoscience Centre Geological Survey of New South WalesLondonderry NSW 2753Australia Head Office Geological Survey of New South WalesMaitland NSW 2320Australia Regional Office Geological Survey of New South WalesOrange NSW 2800Australia

Ordovician conodonts representing 28 genera and 28 named and three unnamed species were identified from 740 chert and siliceous siltstone spot samples(>3000 thin sections)from deep-water turbiditic sequences of the Lachlan Orogen in central and southern New South Wales,*** on these faunas,a new conodont biozonal scheme has been established to divide the Ordovician turbiditic successions of the Lachlan Orogen into 12 superbiozones and *** are(in ascending order)the Paracordylodus gracilis Superbiozone(including the Prioniodus oepiki Biozone),Periodon flabellum Superbiozone(including the Oepikodus evae Biozone in the lower part),Periodon hankensis Biozone,Periodon aculeatus Superbiozone(including the Histiodella labiosa,Histiodella holodentata,Histiodella kristinae,Pygodus serra and Pygodus anserinus biozones)and the Periodon grandis *** Pygodus anserinus Biozone is divided further into the lower and upper *** new conodont biozonation scheme spanning the upper Tremadocian to middle Katian interval permits precise age-dating and correlation of deep-water siliciclastic rocks that characterize the Ordovician Deep-Sea Realm regionally and internationally.

关键词： conodonta Ordovician System correlation deep-water biofacies paleobiogeography

An Unusual, Three-Dimensionally Preserved, Large Hadrosauriform Pes Track from "Mid"-Cretaceous Jiaguan Formation of Chongqing, China

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Acta Geologica Sinica(English Edition) 2012年第2期86卷 304-312页

作者： XING Lida phil R.BELL JeraldD.HARRIS philip J.CURRIE Department of Biological Sciences University of Alberta11455 Saskatchewan DriveEdmontonAlberta T6G 2E9Canada Key Laboratory of Evolutionary Systematics of Vertebrates Chinese Academy of SciencesPO Box 643100044 BeijingChina Pipestone Creek Dinosaur Initiative ClairmontAlberta TOH OWOCanada. Physical Sciences Department Dixie State College225 South 700 EastSt.GeorgeUtah 84770USA

Three-dimensional tracks provide unique insights into the locomotor mechanics of their track makers. An isolated, large hadrosauriform print attributable to Caririchnium lotus from the ＂mid＂-Cretaceous Lotus track site （Jiaguan Formation） in China permits reconstruction of the footfall, weight-bearing, and kick-off phases of the step cycle. Large-scale modifications of the pes during the step cycle indicate C. lotus trackmakers were capable of locomotory modifications in response to substrate consistency beyond the ＂expected＂ shift between bipedal and quadrupedal postures. An unusual curvature to the trace of one of the outer digits indicates substantial transverse mobility. The remaining digits demonstrate lesser degrees of transverse movement accompanied by extension of the digits during footfall. The absence of overprinted scale-scratch marks and toe drags are consistent with a vertical kick-off of the pes and concomitant flexion of the digits. This track suggests that pedal mobility in C. lotus track makers was greater than previously suspected and has implications for reconstructions of hadrosauriform locomotion.

关键词： hadrosauriform locomotion footprints Cretaceous step cycle

彩色印刷复制中色差公式加权系数的计算和可接受阈值的评价

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武汉大学学报（信息科学版） 2006年第9期31卷 814-817页

作者：赵秀萍 phil Green 天津科技大学包装与印刷工程学院伦敦媒体学院数字彩色图像研究中心

对印在有光泽的铜版纸上的9个颜色中心、共216种颜色色样进行了视觉评价和客观测量,得出了每种颜色中心的色差的可接受阈值;然后,应用视觉评价标准确定了可用于CIE94、CMC和CIE2000中的最佳l∶c加权系数,并将ΔE94(l∶c)、ΔEcmc(l∶c)... 详细信息

对印在有光泽的铜版纸上的9个颜色中心、共216种颜色色样进行了视觉评价和客观测量,得出了每种颜色中心的色差的可接受阈值;然后,应用视觉评价标准确定了可用于CIE94、CMC和CIE2000中的最佳l∶c加权系数,并将ΔE94(l∶c)、ΔEcmc(l∶c)、DE2000(l∶c)与ΔEab进行了比较。

关键词：色差 CIE94 CMC CIE2000 加权系数阈值

Rapid ongoing decline of Baird’s tapir in Cusuco National Park, Honduras

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Integrative Zoology 2012年第4期7卷 420-428页

作者： Niall P.McCANN phil M.WHEELER Tim COLES Michael W.BRUFORD School of Biosciences Cardiff UniversityCardiffUK Centre for Environmental and Marine Sciences University of HullScarboroughUK Operation Wallacea Wallace HouseOld BolingbrokeUK

During the International Tapir Symposium 16-21 Oct 2011,the conservation of Baird's tapir(Tapirus baindi)in Honduras received a boost with the signing of a memorandum of understanding between the Minister Direc-tor of the Honduran Instute of Conservation and Forestry(CF)and the Tapir Specialist Group(TSG)Despite this agreement,accelerating levels of hunting and habitat loss contimue to pose a threat to Baird's tapir in *** ongoing study in Cusuco National Park in northwestern Honduras has been monitoring changes in population dynamics of Baird's tapir since 2006 through the collection of occupancy *** study has iden-tified an increase in hunting pressure,coinciding with a drastic decline in the encounter rate with Baird's tapir ***,we examine the significance of a range of demographic variables on Baird's tapir occupancy in Cu-suco National Park using the software PRESENCE,and simulate the effects of different management strategies on the fiuture dynamics of the population using the stochastic simulation software VORTEX The predictions of the theoretical population models are compared to observed changes in occupancy *** found that non-intervention resulted in the local extinction of Baird's tapir within a very short time fiame,but that various in-tervention models enabled the population to recover to near carrying *** and extinction prob-ability were shown to respond marlkedly to the increase in hunting pressure;and occupancy models supported the fiuture population predictions generated by *** study suggests that immediate intervention is re-quired to reduce hunting pressure to near historical levels to prevent the imminent 1ocal extinction of the species.

关键词： Baird's tapir Honduras population viability analysis PRESENCE VORTEX

Comparative Transcriptomic Profiling of Vitis vinifera Under High Light Using a Custom-Made Array and the Affymetrix GeneChip

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Molecular Plant 2011年第6期4卷 1038-1051页

作者： Luisa C. Carvalho Belmiro J. Vilela phil M. Mullineaux Sara Amancio CBAA Instituto Superior de Agronomia Universidade Tecnica de Lisboa Tapada da Ajuda 1349-017 Lisboa Portugal DDSB John Innes Centre Colney Norwich NR4 7UH UK Department of Biological Sciences University of Essex Colchester CO4 3SQ UK

Understanding abiotic stress responses is one of the most important issues in plant research nowadays. Abiotic stress, including excess light, can promote the onset of oxidative stress through the accumulation of reactive oxygen species. Oxidative stress also arises when in vitro propagated plants are exposed to high light upon transfer to ex vitro. To determine whether the underlying pathways activated at the transfer of in vitro grapevine to ex vitro conditions reflect the processes occurring upon light stress, we used Vitis vinifera Affymetrix GeneChip （VvGA） and a custom array of genes responsive to light stress （LSCA） detected by real-time reverse transcriptase PCR （qRT-PCR）. When gene-expression profiles were compared, ＇protein metabolism and modification＇, ＇signaling＇, and ＇anti-oxidative＂ genes were more represented in LSCA, while, in VvGA, ＇cell wall metabolism＇ and ＇secondary metabolism＇ were the categories in which gene expression varied more significantly. The above functional categories confirm previous studies involving other types of abiotic stresses, enhancing the common attributes of abiotic stress defense pathways. The LSCA analysis of our experimental system detected strong response of heat shock genes, particularly the protein rescuing mechanism involving the cooperation of two ATP-dependent chaperone systems, Hsp100 and Hsp70, which showed an unusually late response during the recovery period, of extreme relevance to remove non-functional, potentially harmful polypeptides arising from misfolding, denaturation, or aggregation brought about by stress. The success of LSCA also proves the feasibility of a custommade qRT-PCR approach, particularly for species for which no GeneChip is available and for researchers dealing with a specific and focused problem.

关键词： Quantitative real-time PCR Vitis vinifera GeneChip light stress Heat Shock Proteins oxidative and photooxidative stress.

2023芯片供应链洞察:优先考虑长期的供应链弹性而不是短期效率

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世界电子元器件 2023年第4期 31-32页

作者： phil Gallagher 安富利

我对安富利和整个半导体行业的前景充满信心。虽然我们无法掌控市场,但我们能够帮助客户和供应商合作伙伴在市场竞争中取得优势。成功地做到这一点的关键就是要比以往更深入地与我们的客户和供应商合作。通过合作,我们能够持续保持必要... 详细信息

我对安富利和整个半导体行业的前景充满信心。虽然我们无法掌控市场,但我们能够帮助客户和供应商合作伙伴在市场竞争中取得优势。成功地做到这一点的关键就是要比以往更深入地与我们的客户和供应商合作。通过合作,我们能够持续保持必要的专业知识和能力,帮助他们应对当今复杂的供应链状况。

关键词：供应链半导体行业市场竞争供应商合作伙伴短期效率知识和能力客户