Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

作     者：Chitra Karki Amod Athavale Vijay Abilash Gary Hantsbarger Parnia Geransar Kate Lee Slobodan Milicevic Marko Perovic Leanne Raven Magdalena Sajak-Szczerba Abigail Silber Annabelle Yoon Phil Tozer 

作者机构：Global Evidence and Outcomes-GastroenterologyTakeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Trinity PartnersLLCWalthamMA 02451-7528United States Observational ResearchTakeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Medical AffairsTakeda Pharmaceuticals International Co.Opfikon 8152ZurichSwitzerland Research and Patient ProgramsCrohn’s and Colitis Canada600-60 St.Clair Avenue EastToronto M4T 1N5OntarioCanada TreasurerEuropean Federation of Crohn’s&Ulcerative Colitis AssociationsBrussels B 1000Belgium Crohn’s and Colitis AustraliaCamberwell SouthVIC 3124Australia European Federation of Crohn’s&Ulcerative Colitis AssociationsBrussels B 1000Belgium Japan Medical OfficeTakeda Pharmaceutical Company LimitedTokyo 103-8668Japan Department of Colorectal SurgerySt Mark’s Hospital and Academic InstituteLondon HA13UJUnited Kingdom 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第11期

页      面：2537-2552页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Burden of illness Crohn’s disease Discrete choice experiment Perianal fistulas Patient-reported outcomes Treatment preferences 

摘      要：BACKGROUND Patients with Crohn’s disease(CD)are at risk of developing complications such as perianal *** with Crohn’s perianal fistulas(CPF)are affected by fecal incontinence(FI),bleeding,pain,swelling,and purulent perianal discharge,and METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries(April-August 2021).Patients were recruited into three cohorts:Cohort 1 included patients without perianal fistulas;cohort 2 included patients with perianal fistulas without fistula-related surgery;and cohort 3 included patients with perianal fistulas and fistula-related *** patient-reported outcome measures were used to assess quality of *** of treatment preferences were measured using a discrete choice experiment(DCE).RESULTS In total,929 patients were recruited(cohort 1,n=620;cohort 2,n=174;cohort 3,n=135).Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF(cohorts 2 and 3)than for those with CD without CPF(cohort 1):Mean score 3.8 and 3.7 vs 4.1,respectively,(P0.001).Similarly,mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without *** of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery(cohorts 2 and 3):Mean score 41 and 42,*** the DCE,postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice:Mean relative importance 35.7 and 24.7,*** The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.