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Safety Assessment of Aconitum-Derived Bulleyaconitine A: A 91-Day Oral Toxicity Study and a Tissue Accumulation Study in Rats

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 217-226页

作者： Shi-Liang Yin Feng xu Hao Wu Fei Li Ge Jin Zu-Qian Wu Ran Meng Si-man ma Fan Zhou peter Breslin Chun-Fu Wu Hong Zhang Department of Pharmacology School of PharmacyShenyang Medical College Department of Pharmacology School of Life Science and BiopharmaceuticsShenyang Pharmaceutical UniversityShenyang State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin Department of Pharmaceutical Analysis School of PharmacyShenyang Pharmaceutical UniversityShenyang Department of Hematology General Hospital of Northern Theater CommandShenyangChina Department of Biology and Molecular Cellular Physiology Loyola University ChicagoChicagoIllinoisUSA

Background:Bulleyaconitine A(BLA)is a diterpenoid alkaloid from the rhizomes of Aconitum bulleyanum Diels and has been clinically used for chronic pain treatment in China for many ***,the newly reported adverse events of BLA indicated that BLA still has potential safety *** and Methods:To assess the safety of BLA,analgesic tests,acute toxicity studies,repeated-dose oral toxicity studies,and tissue distribution studies after single and repeated administration of BLA were carried ***:Administration of 0.14 mg/kg BLA showed potent analgesic effects in both analgesic *** acute toxicity study,the LD50 value of BLA was calculated to be 3.4434 mg/*** the subchronic toxicity study,the no observed adverse effect level was 0.25 mg/kg,and the lowest observed adverse effect level was 0.5 mg/*** spleen,liver,and kidneys are newly identified target organs of BLA toxicity after long-term ***,unlike a single BLA administration,repeated administration showed BLA redistribution from organs with an abundant blood supply to immune and metabolic ***:These results suggested that BLA itself would be nontoxic at a dosage of 0.25 mg/kg in rats and should be carefully used when combining BLA with medications that can cause spleen,liver,or kidney injury.

关键词： Adverse reaction bulleyaconitine A repeated-dose(91-day)toxicity tissue distribution

The Global boundary Stratotype Section and Point （GSSP） of the Ladinian Stage （Middle Triassic） at Bagolino （Southern Alps, Northern Italy） and its implications for the Triassic time scale

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Episodes 2005年第4期28卷 233-244页

作者： peter Brack Hans Riebe Alda Nicora Roland Mundil Departement Erdwissenschaften ETH-Zentrum CH-8092 Zurich Switzerland. Palaontologisches Instituit Universitat ZurichCH-8006ZurichSwitzerland. Dipartimento di Scienze della Terra Universita di Milano Via Mangiagaiii 341-20133 Milano Italy. Berkeley Geochronology Center 2455 Ridge Road Berkeley CA 94709 USA

The Global boundary Stratotype Section and Point （GSSP） for the base of the Ladinian Stage （Middle Triassic） is defined in the Caffaro river bed （45°49＇09.5＂N, 10°28＇15.5＂E）, south of the village of Bagolino （Province of Brescia, northern Italy）, at the base of a 15-20-cm-thick limestone bed overlying a distinct groove （＂Chiesense groove ＂） of limestone nodules in a shaly matrix, located about 5 m above the base of the Buchenstein Formation. The lower surface of the thick limestone bed has the lowest occurrence of the ammonoid Eoprotrachyceras curionii （base of the E. curionii Zone; onset of the Trachyceratidae ammonoid family）. Secondary global markers in the uppermost Anisian include the lowest occurrence of conodont Neogondolella praehungafica and a brief normal-polarity magnetic zone recognized in closely correlated sections including the principal auxiliary section at Seceda in the Dolomites. The GSSP-level is bracketed by U-Pb single zircon age data from volcaniclastic horizons, indicating a boundary age of ca 241 ma.

关键词：三叠纪镧阿尔卑斯山意大利 GSSP

Differences in physiological integration between invasive and noninvasive introduced clonal species of Carpobrotus

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Journal of Plant Ecology 2019年第6期12卷 972-981页

作者： Sergio R.Roiloa peter Alpert Rodolfo Barreiro BioCost Group Biology DepartmentUniversidade da CoruñaA CoruñaSpain Biology Department University of MassachusettsAmherstMA 01003USA

Aims Clonal growth is associated with invasiveness in introduced plant species,but few studies have compared invasive and noninvasive introduced clonal species to investigate which clonal traits may underlie *** test the hypothesis that greater capacity to increase clonal growth via physiological integration of connected ramets increases invasiveness in clonal plants,we compared the effects of severing connections on accumulation of mass in the two species of the creeping,succulent,perennial,herbaceous genus Carpobrotus that have been introduced on sand dunes along the Pacific Coast of northern California,the highly invasive species Carpobrotus edulis and the co-occurring,noninvasive species Carpobrotus *** Pairs of ramets from four mixed populations of the species from California were grown in a common garden for 3 months with and without severing the stem connecting the *** simulate the effect of clones on soils in natural populations,the older ramet was grown in sand amended with potting compost and the younger in sand *** Findings Severance decreased net growth in mass by~60%in *** and~100%in ***,due mainly to the negative effect of severance on the shoot mass of the younger ramet within a *** to the hypothesis,this suggests that physiological integration increases growth more in the less invasive ***,severance also decreased allocation of mass to roots in the older ramet and increased it in the younger ramet in a pair,and the effect on the younger ramet was about twice as great in *** as in *** indicates that the more invasive species shows greater phenotypic plasticity in response to physiological integration,in particular greater capacity for division of *** could contribute to greater long-term growth and suggests that the division of labor may be a trait that underlies the association between clonal growth and invasiveness in plants.

关键词： biomass allocation Carpobrotus clonal growth physiological integration plant invasions

Geochronological constraints on 140-85 ma thermal doming extension in the Dabie orogen, central China

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Science China Earth Sciences 2002年第9期45卷 801-817页

作者：许长海周祖翼马昌前 peter W. Reiners 1. MOU Laboratory of marine Geology Tongji University 200092 Shanghai China 2. Faculty of Earth Sciences China University of Geosciences 430074 Wuhan China 3. Department of Geology Washington State University 99164-2812 Pullman WA USA

Regional architecture of geochronology and differential cooling pattern show that the Dabie orogen underwent a thermal doming extension during 140-85 ma. This extension resulted in widespread re-melting of the Dabie basement, intense volcanic activities in North Huaiyang and the formation of fault-controlled depressions in the Hefei basin. This thermal doming extension can be further divided into two consecutive evolving stages, i.e. the intensifying stage (140-105 ma) and the declining stage (105-85 ma). In the first stage (140-105 ma), the thermal doming mainly was concentrated in the Dabie block, and to a less degree, in the Hongan block. The thermal doming structure of the Dabie block is configured with macheng-Yuexi thermal axis, Yuexi/Luotian thermal cores and their downslide flanks. The orientation of thermal axis is dominantly parallel to the strike of orogen, and UHP/HP units together with metamorphic rocks of North Huaiyang constitute the downslide flanks. The Yuexi core differs from the Luotian core in both the intensity and the shaping time. To some extent, the Hongan block can be regarded as part of downslide systems of the Dabie doming structure. The doming process is characterized by thermal-center's migration along the macheng-Yuexi thermal axis; consequently, it is speculated to be attributed to the convective removal of thickened orogenic root, which is a process characterized by intermittance, migration, large-scale and differentiation. During the declining stage (105-85 ma), the dome- shaped figure still structurally existed in the Dabie orogen, but orogenic units cooled remarkably slow and magmatic activities stagnated gradually. Study on the thermal doming of Dabieshan Mountains can thus provide detailed constraints on the major tectonic problems such as the UHP/HP exhumation model, the boundary between North Dabie and South Dabie, and the orogenesis mechanism.

关键词： Dabie orogen, geochronology, cooling pattern, thermal doming extension.

Derived, still living cockroach genus Cariblattoides （Blattida： Blattellidae） from the Eocene sediments of Green River in Colorado, USA

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Insect Science 2012年第2期19卷 143-152页

作者： peter Vrsansky L＇ubomir Vidlicka Fedor Ciampor Jr Finnegan marsh Geological Institute SlovakAcademy of Sciences BraUslava Slovakia Paleontological Institute Russian Academy of Sciences Moscow Russia Institute of Zoology Slovak Academy of Sciences Department of Biology Faculty of Education Comenius University Bratislava Slovakia Department of Paleobiology National Museum of Natural History Smithsonian Institution Washington DC USA

Cariblattoides labandeirai sp.n. from the Eocene sediments of Green River in Colorado, USA bear only two plesiomorphies, but also several significant autapomorphies within the advanced and highly derived living cockroach genus. Thus, Cariblattoides with extant occurrence in the Caribbean and South America was historically common in the Nearctic, and represents important evidence for the occurrence of derived living genera of cockroaches -50 ma ago. Generally, the vast majority of living genera were absent during the Palaeocene, thus the diversification of most living cockroach lineages near the Palaeocene/Eocene boundary must have been extremely rapid. Females of living C. suave, the type species, have identical （sophisticated） coloration ofpronotum, but the most related living taxa are C. piraiensis and *** from Brazil （supported by phylogenetical analysis）.

关键词： Blattida -- Blattaria = Blattodea Cariblattoides Eocene fossil insects,Green River Tertiary cockroaches

High Responsivity and Ultra-Low Detection Limits in Nonlinear a-Si:H p-i-n Photodiodes Enabled by Photogating

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Photonic Sensors 2023年第4期13卷 27-38页

作者： Andreas BABLICH maurice MÜLLER Rainer BORNEmaNN Andreas NACHTIGAL peter HARING BOLÍVAR Institute of Graphene-Based Nanotechnology University of SiegenHölderlinstr.357076 SiegenGermany Institute of High Frequency and Quantum Electronics University of SiegenHölderlinstr.357076 SiegenGermany

Photodetectors operating at the wavelength in the visible spectrum are key components in high-performance optoelectronic *** this work,massive nonlinearities in amorphous silicon p-i-n photodiodes enabled by the photogating are presented,resulting in responsivities up to 744 ma/W at blue *** detectors exhibit significant responsivity gains at optical modulation frequencies exceeding MHz and a more than 60-fold enhanced spectral response compared to the non-gated *** detection limits down to 10.4 nW/mm^(2) and mean signal-to-noise ratio enhancements of 8.5dB are demonstrated by illuminating the sensor with an additional 6.6μW/mm^(2) red ***-optical simulations verify photocarrier modulation due to defect-induced field screening to be the origin of such high responsivity *** experimental results validate the theory and enable the development of commercially viable and complementary metal oxide semiconductor(CMOS)compatible high responsivity photodetectors operating in the visible range for low-light level imaging and detection.

关键词： Photogating amorphous silicon a-Si:H nonlinearity photodetector responsivity gain

The South China Sea thermohaline structure and circulation

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Acta Oceanologica Sinica 2002年第2期21卷 227-261页

作者： peter C. Chu, Binbing ma, Yuchun Chen1. Naval Postgraduate School, Monterey, California, USA2. Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences, Lanzhou, China Naval Postgraduate School

In this study, we used the Navy' s master Oceanographic Observation Data Set(MOODS), consisting of 116019 temperature and 9617 salinity profiles, during 1968-1984 to investigate the temporal and spatial variabilities of South China Sea thermohaline structures and circulation. For temperature, profiles were binned into 204 monthly data sets from 1968 to 1984 (17 years). For salinity, profiles were binned into 12 climatological monthly data sets due to the data paucity. A two-scale optimal interpolation method was used to establish a three-dimensional monthly-varying gridded data set from MOODS, covering the area of 5°-25°N and 105° - 125°E and the depth from the surface to 400 m. After the gridded data set had been established, both composite analysis and the Empirical Orthogonal Function (EOF) analysis (for temperature only) were used to identify the major thermohaline fratures including annual mean, monthly anomalies, and interannual thermal variabilities. The inverted monthly circulation pattern using the P - vector method is also discussed.

关键词： The South China Sea thermohaline structure circulation

An automated, 0.5 Hz nano-foil target positioning system for intense laser plasma experiments

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High Power Laser Science and Engineering 2017年第2期5卷 52-56页

作者： Ying Gao Jianhui Bin Daniel Haffa Christian Kreuzer Jens Hartmann martin Speicher Florian H.Lindner Tobias M.Ostermayr peter Hilz Thomas F.Rsch Sebastian Lehrack Franz Englbrecht Sebastian Seuferling max Gilljohann Hao Ding Wenjun ma Katia Parodi Jorg Schreiber Lehrstuhl fur Medizinphysik Fakultat fUr PhysikLudwig-Maximilians-Universitat MiinchenAm Coulombwall 1D-85748GarchingGermany max-Planck-lnstitut fur Quantenoptik D-85748 GarchingGermany peking University Beijing 100871PR China

We report on a target system supporting automated positioning of nano-targets with a precision resolution of 4 μm in three dimensions. It relies on a confocal distance sensor and a microscope. The system has been commissioned to position nanometer targets with 1 Hz repetition rate. Integrating our prototype into the table-top ATLAS 300 TW-laser system at the Laboratory for Extreme Photonics in Garching, we demonstrate the operation of a 0.5 Hz laser-driven proton source with a shot-to-shot variation of the maximum energy about 27% for a level of confidence of 0.95. The reason of laser shooting experiments operated at 0.5 Hz rather than 1 Hz is because the synchronization between the nano-foil target positioning system and the laser trigger needs to improve.

关键词： high intense laser nm thick target positioning system repetition rated laser-driven ion source

汽车摩擦材料缩比Krauss摩擦试验机的研制及比较性评价

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机械工程学报 2020年第21期56卷 158-167页

作者：王振玉王杰王利宁 peter K 马云海王铁山四川大学机械工程学院成都610065 成都理工大学工程技术学院乐山614000 吉林大学机电设备研究所长春130117 吉林大学生物与农业工程学院长春130022 Krauss GmbH-Link Engineering Company Murr 71711德国

为了提高小样试验工况的可模拟性,降低试验成本,提高试验效率,以Krauss试验机为原型,根据相似原理,应用量纲分析法推导缩比Krauss试验机的基本参数,研制了一种缩小比例的Krauss试验机。选用PVW-3212试验规程,选取同一批次汽车制动衬片... 详细信息

为了提高小样试验工况的可模拟性,降低试验成本,提高试验效率,以Krauss试验机为原型,根据相似原理,应用量纲分析法推导缩比Krauss试验机的基本参数,研制了一种缩小比例的Krauss试验机。选用PVW-3212试验规程,选取同一批次汽车制动衬片进行试验研究,通过对摩擦因数、试验温度和试验周期等指标进行比较。结果表明,全程平均摩擦因数较接近,摩擦因数最大值和最小值出现的阶段和制动次序均相同,全程平均温度具有很好的线性相关性。执行相同PVW-3212试验规程的情况下,在制动初始和制动解除阶段,缩比Krauss试验机压力响应较快,全尺寸Krauss试验机压力响应较慢,缩比试验制动结束时间提前约100 ms,每次试验成本约为全尺寸Krauss试验机的29.67%。缩比Krauss试验机与全尺寸Krauss试验机具有较好的一致性和可比性,证明了该缩比Krauss试验机的可靠性,为摩擦材料的测试提供了一种新的试验装置。

关键词：摩擦材料相似理论 Krauss试验机对比试验摩擦磨损