The contradictory role of androgens in cutaneous and major burn wound healing
作者机构：Burns Research GroupANZAC Research InstituteUniversity of SydneyConcord HospitalGate3 Hospital roadConcordNSW 2139Australia AndrologyANZAC Research InstituteUniversity of SydneyConcord HospitalGate3 Hospital roadConcordNSW 2139Australia Adrenal Steroid LaboratoryANZAC Research InstituteUniversity of SydneyConcord HospitalGate3 Hospital roadConcordNSW 2139Australia Burns and Reconstructive Surgery UnitConcord HospitalGate3 Hospital roadConcordNSW 2139Australia
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2021年第9卷第1期
页 面：545-557页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0202[经济学-应用经济学] 02[经济学] 1002[医学-临床医学] 020205[经济学-产业经济学] 1001[医学-基础医学(可授医学、理学学位)] 1011[医学-护理学（可授医学、理学学位）] 0836[工学-生物工程]
主 题：Wound healing Androgen Mouse model Oxandrolone Cutaneous injury Major burn injury
摘 要：Wound healing is a complex process involving four overlapping phases:haemostasis,inflammation,cell recruitment and matrix *** mouse models,surgical,pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-αproduction and reduce wound re-epithelization and matrix deposition,retarding cutaneous wound ***,clinical studies have shown that cutaneous wound healing is slower in men compared to ***,in major burn injury,which triggers not only local wound-healing processes but also systemic hypermetabolism,the role of androgens is poorly *** studies have claimed that a synthetic androgen,oxandrolone,increases protein synthesis,improves lean body mass and shortens length of hospital ***,the possible mechanisms by which oxandrolone regulates major burn injury have not been *** this review,we summarize the current findings on the roles of androgens in cutaneous and major burn wound healing,as well as androgens as a potential therapeutic treatment option for patients with major burn injuries.
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