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Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： MJ Mahesh Kumar Shailendra Arindkar Masum Saini perumal nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

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Genetically modified mouse models for the study of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第11期18卷 1141-1153页

作者： perumal nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma Small Animal Facility National Institute of Immunology NewDelhi 110067 India Animal House Centre for Cellularand Molecular Biology Hyderabad 500007 India Animal House JNU New Delhi110067 India

Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 *** represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) *** animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of *** study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely *** different mouse models can be classified in two large *** first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological *** the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of *** animal models for NASH should closely resemble the pathological characteristics observed in *** date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human ***,it is important that the researchers choose the appropriate animal *** review discusses various genetically modified animal models developed and used in research on NAFLD.

关键词：转基因小鼠模型脂肪肝酒精性转基因动物模型肝病人类疾病 NASH 发病机制

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