Genetically modified mouse models for the study of nonalcoholic fatty liver disease

作     者：Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma 

作者机构：Small Animal Facility National Institute of Immunology NewDelhi 110067 India Animal House Centre for Cellularand Molecular Biology Hyderabad 500007 India Animal House JNU New Delhi110067 India 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第11期

页      面：1141-1153页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Nonalcoholic fatty liver disease Steatosis Steatohepatitis Knockout Animal models 

摘      要：Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 *** represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) *** animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of *** study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely *** different mouse models can be classified in two large *** first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological *** the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of *** animal models for NASH should closely resemble the pathological characteristics observed in *** date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human ***,it is important that the researchers choose the appropriate animal *** review discusses various genetically modified animal models developed and used in research on NAFLD.