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肝脏CT影像纹理特征预测结直肠癌病人的肝转移和总生存期

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国际医学放射学杂志 2018年第3期 369-370页

作者： S.j.Lee R.Zea D.H.Kim M.G.Lubner D.A.Deming P.j.pickhardt 刘磊 Department of Radiology University of Wisconsin School of Medicine and Public Health

摘要目的探讨结直肠癌(CRC)病人在腹部CT发现确切的肝转移前是否出现肝纹理特征的改变。方法从肝脏门静脉期的影像上提取四过滤-直方图纹理特征(标准差、偏

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怀疑阑尾炎CT检查的其他诊断

国际医学放射学杂志 2013年第1期 72-73页

作者： B.D.Pooler E.M.Lawrence P.j.pickhardt 程悦 Department of Radiology University of Wisconsin School of Medicine and Public HealthE3/311 Clinical Science Center600HighlandAveMadisonWI53792-3252

目的评价临床工作中因怀疑急性阑尾炎而进行CT检查的成人中的其他诊断。材料与方法本回顾性研究符合HIPAA要求,得到单位伦理委员会的批准,无需知情同意书。连续性回顾2006年1月—2009年12月期间因怀疑急性阑尾炎就诊于同一学术医疗机构... 详细信息

目的评价临床工作中因怀疑急性阑尾炎而进行CT检查的成人中的其他诊断。材料与方法本回顾性研究符合HIPAA要求,得到单位伦理委员会的批准,无需知情同意书。连续性回顾2006年1月—2009年12月期间因怀疑急性阑尾炎就诊于同一学术医疗机构急诊科和急救室的1571例成年病人。由具执业资质的放射科医师对腹盆CT做出诊断,并综合临床、手术、病理和其他影像学发现做出最终诊断。采用Fisher精确检验和Mann-Whitney检验进行统计分析,以双尾P值<0.05为差异有统计学意义。结果 1571例中867例(55.2%)在CT检查中得出特异性诊断。371例(23.6%)倾向于急性阑尾炎,496例(31.6%)被诊断为阑尾炎以外的其他疾病。在获得阑尾炎以外其他CT诊断的496例病人中,204例(41.1%)进行了住院治疗,109例(22.0%)由于非阑尾炎原因而进行了手术或影像导向的介入治疗;而在CT检查没有做出特异性诊断的病人中,住院和外科治疗的比例分别为14.1%和4.4%(P<0.0001)。最常见的疾病种类包括阑尾以外的胃肠道疾病(46.0%)、妇科疾病(21.6%)、泌尿生殖系统疾病(16.9%)和肝胆胰疾病(7.7%)。结论对于临床怀疑急性阑尾炎的成人,腹盆CT常可以发现引起症状的其他原因,这些疾病常需住院和手术治疗。

关键词：阑尾炎成人肠疾病 CT 疾病

低剂量CT平扫检测到50岁以上无症状女性偶然附件肿块:涉及临床治疗和卵巢癌筛查

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国际医学放射学杂志 2010年第6期 574-575页

作者： P.j.pickhardt M.E.Hanson 张继扬 Department of Radiology University of Wisconsin School of Medicine and Public HealthE3/311 Clinical Science Center600 Highland AveMadisonWI 53792-3252

目的确定低剂量CT平扫对50岁以上无症状、经过结肠造影筛查的女性不明确附件肿块的患病率、检查及结果的辨别。材料与方法这项研究经机构审查委员会批准并

关键词：卵巢癌卵巢恶性肿瘤卵巢肿瘤筛查低剂量无症状 CT 平扫女性

Leptin rescues neurons from Alzheimer’s disease-related pathways triggered by lipid burden

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Advances in Alzheimer's Disease 2013年第1期2卷 31-39页

作者： Steven j. Greco George perry j. Wesson Ashford Ashkan Hamzelou jane M. johnston Nikolaos Tezapsidis Neurotez Inc. Bridgewater USA Stanford/VA Medical Center Palo Alto USA University of Texas San Antonio USA

Adipocyte-derived leptin is a pleiotropic hormone implicated in control of lipid storage and mobilization, bone homeostasis, immune function and neuronal plasticity. Leptin has been shown to prevent accumulation of extracellular Aβ and hyperphosphorylation of tau in both cell culture and animal models. Herein an investigation was undertaken to test leptin’s ability to prevent the exacerbation/activation of AD-related pathways in neurons following their exposure to a high concentration of a variety of lipids. Specifically, cholesterol, oleic acid and/or ceramide were added to the media of cells resulting in decreased cellular viability and energy metabolism, and in increased tau phosphorylation and extracellular Aβ. Leptin increased viability, boosted cellular metabolism by activating AMP-activated protein kinase (AMPK) and the sirtuins (SIRT) and reduced tau phosphorylation and Aβ accumulation in a dose-dependent manner in response to select challenges. These findings demonstrate that leptin can attenuate the harmful effect of certain lipids that lead to exacerbation or activation of AD pathways. The study herein also provides the basis for a novel screening platform to define and identify a novel class of “metabolic” compounds addressing Alzheimer’s disease, based on a biological profile similar to leptin.

关键词： Leptin Cholesterol Ceramide AMPK SIRT Alzheimer’s Tau Amyloid-β

Direct laser writing of volumetric gradient index lenses and waveguides

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Light(Science & Applications) 2020年第1期9卷 89-102页

作者： Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner j.Garcia jorik van de Groep jung-Hwan Song Austin j.Cyphersmith Andrew Rhode Andrea N.perry Alexander j.Littlefield jinlong Zhu Dajie Xie Haibo Gao jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint jr Lynford L.Goddard Paul V.Braun Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaILUSA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Materials Science and Engineering Stanford UniversityStanfordCAUSA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA

Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer ***,these printed structures are limited to the refractive index and dispersive properties of the ***,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica *** the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic *** SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible ***’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing *** also has the potential to form multicomponent optics by cascading optical elements within a *** a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous ***,an all-pass ring resonator was coupled to a subsurface 3D *** measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple *** is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports.

关键词： index refractive render

Outcomes following liver transplantation in intensive care unit patients

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World journal of Hepatology 2013年第1期5卷 26-32页

作者： Lena Sibulesky Michael G Heckman C Burcin Taner juan M Canabal Nancy N Diehl Dana K perry Darren L Willingham Surakit Pungpapong Barry G Rosser David j Kramer justin H Nguyen Department of Transplantation Mayo ClinicJacksonvilleFL 32225United States Biostatistics Unit Mayo ClinicJacksonvilleFL 32225United States Departments of Transplantation and Critical Care Medicine Mayo ClinicJacksonvilleFL 32225United States Department of Critical Care Medicine and Internal Medicine Aurora Health CareMilwaukeeWI 53204United States

AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient ***:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between january 2005 and December ***:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and *** ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to ***-five ICU patients (64%) required dialysis *** 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU *** survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU *** formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable *** findings were consistent in multivariable *** not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (

关键词： Donor pool Donor outcomes Onor after cardiac death grafts Liver graft survival Patient survival

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Microbial life

Microbial life

文化帝国主义的回潮?--重估民国教会大学的历史遗产

2002年

作者： jerome j. perry james T. Staley Stephen Lory

Includes bibliographical references and index.

ISBN: (纸本)0878936785

Includes bibliographical references and index.

关键词： Microbiology

来源：畅想之星图书光盘版（南... 评论

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清华大学教育研究 2020年第2期41卷 30-40页

作者：裴宜理涂航哈佛大学政府系美国马塞诸塞哈佛大学东亚语言与文明系美国马塞诸塞

在当下中国,随着建设"具有中国特色的世界一流大学",民国教会大学的教育理念和实践也重新成为社会各界关注的热点。教会大学究究竟是中外合作办学的先驱,还是文化帝国主义的象征?本文试图将当今中国高等教育国际化改革的两个案例(上海... 详细信息

在当下中国,随着建设"具有中国特色的世界一流大学",民国教会大学的教育理念和实践也重新成为社会各界关注的热点。教会大学究究竟是中外合作办学的先驱,还是文化帝国主义的象征?本文试图将当今中国高等教育国际化改革的两个案例(上海纽约大学与燕京学堂)与民国两所顶尖教会大学的本土化实践(圣约翰大学与燕京大学)进行制度、文化以及学术层面的比较,以重估民国教会大学的历史遗产。

关键词：民国教会大学文化帝国主义高等教育的本土化实践

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化学气相沉积碳化钛涂覆钢面

金属热处理 1979年第9期 59-64页

作者： A.j.perry 吴国华

近年来,将碳化钛涂覆在工具钢上的应用在稳步地发展,它可以提高工具钢的抗磨损和使用寿命。现在用化学气相沉积法方便而经济地得到这样的涂层。本文叙述了工业上化学气相沉积(CVD)处理过程,以及与钢基体相结合的某些问题,并且也说明了... 详细信息

近年来,将碳化钛涂覆在工具钢上的应用在稳步地发展,它可以提高工具钢的抗磨损和使用寿命。现在用化学气相沉积法方便而经济地得到这样的涂层。本文叙述了工业上化学气相沉积(CVD)处理过程,以及与钢基体相结合的某些问题,并且也说明了用于冷成形加工的,以 TiC 涂覆的莱氏体工具钢的两种实际应用情况。用于冷作加工操作的现代工具要求高强

关键词：化学气相沉积工具钢涂层化学汽相沉积化学沉积碳化物碳化合物残余奥氏体涂覆奥氏体化口口硬度值莱氏体钢马氏体转变金属转变