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Targeting growth hormone function: strategies and therapeutic applications

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Signal Transduction and Targeted Therapy 2019年第1期4卷 614-624页

作者： Man Lu jack U.Flanagan Ries j.Langley Michael P.Hay jo K.perry Liggins Institute University of AucklandAucklandNew Zealand Auckland Cancer Society Research Centre School of Medical SciencesUniversity of AucklandAucklandNew Zealand Maurice Wilkins Centre for Molecular Biodiscovery AucklandNew Zealand Department of Molecular Medicine and Pathology School of Medical SciencesUniversity of AucklandAucklandNew Zealand

Human growth hormone(GH)is a classical pituitary endocrine hormone that is essential for normal postnatal growth and has pleiotropic effects across multiple physiological *** is also expressed in extrapituitary tissues and has localized autocrine/paracrine effects at these *** adults,hypersecretion of GH causes acromegaly,and strategies that block the release of GH or that inhibit GH receptor(GHR)activation are the primary forms of medical therapy for this *** of GH has also been linked to cancer and the microvascular complications that are associated with ***,studies to investigate the therapeutic potential of GHR antagonism in these diseases have been limited,most likely due to difficulty in accessing therapeutic tools to study the pharmacology of the receptor in *** review will discuss current and emerging strategies for antagonizing GH function and the potential disease indications.

关键词： therapeutic pituitary diseases

Preoperative phenylephrine testing as a predictor of postoperative eyebrow position

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International journal of Ophthalmology(English edition) 2016年第3期9卷 472-474页

作者： Tal j.Rubinstein Austin j.Woolley Bryan R.Costin julian D.perry Cole Eye Institute Cleveland Clinic Foundation ClevelandOH 44195 USA Case Western Reserve University School of Medicine Cleveland OH 44106 USA

Dear Sir,Eyebrow position and contour strongly influences overall facial cosmesis tl-31 and depends on many factors,sinus pneumatization, prior surgery, and cultural trends .

关键词： Figure MRD CBH

Long, thin transmission chains of Severe Acute Respiratory Syndrome Coronavirus 2 may go undetected for several weeks at low to moderate reproduction numbers: Implications for containment and elimination strategy

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Infectious Disease Modelling 2021年第1期6卷 474-489页

作者： Gerry F.Killeen Patricia M.Kearney Ivan j.perry Niall Conroy School of Biological Earth&Environmental SciencesUniversity College CorkCorkIreland Environmental Research Institute University College CorkCorkIreland School of Public Health University College CorkCorkIreland Wide Bay Public Health Unit QueenslandAustralia Faculty of Medicine University of QueenslandBrisbaneQueenslandAustralia

Severe Acute Respiratory Syndrome Coronavirus 1(SARS-CoV-1)infections almost always caused overt symptoms,so effective case and contact management enabled its effective eradication within ***,Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)usually causes only mild symptoms,so transmission chains may grow to include several individuals before at least one index case becomes ill enough to self-report for diagnosis and ***,simple mathematical models were developed to evaluate the implications of delayed index case detection for retrospective contact tracing and management ***,these simulations illustrate how:(1)Contact tracing and management may effectively contain most but not all large SARS-CoV-2 clusters arising at foci with high reproduction numbers because rapidly expanding transmission chains ensure at least one overtly symptomatic index case occurs within two viral generations a week or less apart.(2)However,lower reproduction numbers give rise to thinner transmission chains extending through longer sequences of non-reporting asymptomatic and paucisymptomatic individuals,often spanning three or more viral generations(2 weeks of transmission)before an overtly symptomatic index case occurs.(3)Consequently,it is not always possible to fully trace and contain such long,thin transmission chains,so the community transmission they give rise to is underrepresented in surveillance data.(4)Wherever surveillance systems are weak and/or transmission proceeds within population groups with lower rates of overt clinical symptoms and/or self-reporting,case and contact management effectiveness may be more severely limited,even at the higher reproduction numbers associated with larger outbreaks.(5)Because passive surveillance platforms may be especially slow to detect the thinner transmission chains that occur at low reproduction numbers,establishing satisfactory confidence of elimination may require that no confirmed cases are detec

关键词： Coronavirus COVID SARS2 Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 Model Epidemiology Outbreak Case and contact management

Genome-wide Scan for Seed Composition Provides Insights into Soybean Quality Improvement and the Impacts of Domestication and Breeding

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Molecular Plant 2018年第3期11卷 460-472页

作者： jiaoping Zhang Xianzhi Wang Yaming Lu Siddhi j. Bhusal Qijian Song perry B. Cregan Yang Yen Michael Brown Guo-Liang jiang Plant Science Department South Dakota State University Brookings SD 57006 USA Soybean Genomics and Improvement Laboratory US Department of Agriculture Agricultural Research Services (USDA-ARS) 10300 Baltimore Avenue BeltsvilleMD 20705 USA Department of Biology and Microbiology South Dakota State University Brookings SD 57006 USA Department of Natural Resource Management South Dakota State University Brookings SD 57006 USA Agricultural Research Station Virginia State University PO Box 9061 Petersburg VA 23806 USA Present address: School of Agriculture Yunnan University Kunming Yunnan Province China These authors contributed equally to this article.

The complex genetic architecture of quality traits has hindered efforts to modify seed nutrients in soybean. Genome-wide association studies were conducted for seed composition, including protein, oil, fatty acids, and amino acids, using 313 diverse soybean germplasm accessions genotyped with a high-density SNP array. A total of 87 chromosomal regions were identified to be associated with seed composition, explain- ing 8%-89% of genetic variances. The candidate genes GmSAT1, AK-HSDH, SACPD-C, and FAD3A of known function, and putative MtN21 nodulin, FATB, and steroid-5-^-reductase involved in N2 fixation, amino acid biosynthesis, and fatty acid metabolism were found at the major-effect loci. Further analysis of additional germplasm accessions indicated that these major-effect loci had been subjected to domes- tication or modern breeding selection, and the allelic variants and distributions were relevant to geographic regions. We also revealed that amino acid concentrations related to seed weight and to total protein had a different genetic basis. This helps uncover the in-depth genetic mechanism of the intricate relationships among the seed compounds. Thus, our study not only provides valuable genes and markers for soybean nutrient improvement, both quantitatively and qualitatively, but also offers insights into the alteration of soybean quality during domestication and breeding.

关键词： genome-wide association study GWAS soybean seed composition candidate genes quality improvement domestication and breeding

Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways

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Science China(Life Sciences) 2023年第8期66卷 1915-1929页

作者： Chao Li Li Tao Guobo Guan Zhangyue Guan Austin M.perry Tianren Hu jian Bing Ming Xu Clarissa j.Nobile Guanghua Huang Department of Infectious Diseases Huashan HospitalShanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic EngineeringSchool of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Molecular and Cell Biology University of CaliforniaMercedMerced CA 95343USA Quantitative and Systems Biology Graduate Program University of CaliforniaMercedMerced CA 95343USA Health Sciences Research Institute University of CaliforniaMercedMerced CA 95343USA Shanghai Engineering Research Center of Industrial Microorganisms Shanghai 200438China Shanghai Huashen Institute of Microbes and Infections Shanghai 200052China

Sexual reproduction is prevalent in eukaryotic organisms and plays a critical role in the evolution of new traits and in the generation of genetic *** factors often have a direct impact on the occurrence and frequency of sexual reproduction in *** regulatory effects of atmospheric relative humidity(RH)on sexual reproduction and pathogenesis in plant fungal pathogens and in soil fungi have been extensively ***,the knowledge of how RH regulates the lifecycles of human fungal pathogens is *** this study,we report that low atmospheric RH promotes the development of mating projections and same-sex(homothallic)mating in the human fungal pathogen Candida *** RH causes water loss in *** cells,which results in osmotic stress and the generation of intracellular reactive oxygen species(ROS)and *** water transporting aquaporin Aqy1,and the G-protein coupled receptor Gpr1 function as cell surface sensors of changes in atmospheric *** of the trehalose metabolic pathway by inactivating trehalose synthase or trehalase promotes same-sex mating in *** by increasing osmotic or ROS stresses,*** trehalose and ROS signal the Hog1-osmotic and Hsf1-Hsp90 signaling pathways to regulate the mating ***,therefore,propose that the cell surface sensors Aqy1 and Gpr1,intracellular trehalose and ROS,and the Hog1-osmotic and Hsf1-Hsp90 signaling pathways function coordinately to regulate sexual mating in response to low atmospheric RH conditions in ***.

关键词： atmospheric relative humidity sexual reproduction same-sex mating Candida albicans trehalose metabolism osmotic stress

维普期刊数据库

Solid-State Metal Additive Manufacturing for Structural Repair

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Accounts of Materials Research 2021年第9期2卷 780-792页

作者： Ryan B.Gottwald R.joey Griffiths Dylan T.Petersen Mackenzie E.j.perry Hang Z.Yu Department of Materials Science and Engineering Virginia TechBlacksburgVirginia 24061United States

CONSPECTUS:Structural metal components play a vital role in a broad range of industries,from aerospace and automotive to infrastructure and *** service,these components can experience substantial wear,thermal fatigue,erosion,corrosion,or chemical reactions,resulting in significant surface or even volumetric *** of these components is often energy-intensive and economically *** repair,which aims to restore the original geometry while enabling good mechanical performance postrepair,can offset the costs *** on the additive capabilities and bonding mechanisms,structural repair technologies can be divided into four categories:nonadditive,nonmelting-based;nonadditive,melting-based;additive,nonmelting-based;additive,*** melting-based approaches can be applied to various repair geometries with good precision,the underlying melting and solidification processes inevitably lead to crucial problems impacting the mechanical performance,such as solidification porosity,high residual stresses,dendritic microstructure formation,elemental segregation,hot cracking,and stress corrosion *** fundamentally solve or minimize these problems,one may employ solid-state technologies that leverage ultrasonic vibration,friction stirring,or particle impact to facilitate metallurgical bond *** robust geometry restoration,an additive capability needs to be incorporated for continuous material feeding and precise deposition path ***,two solid-state technologies satisfy the requirement,cold spray and additive friction stir *** this Account,we discuss the structural repair enabled by solid-state metal additive manufacturing,focusing on(i)cold spray,which is a relatively established process,and(ii)additive friction stir deposition,which is an emerging process recently triggering significant research effortsthe authors are particularly invested in this process and are pioneering th

关键词： friction solidification corrosion

Multimedia developer''s guide 1st ed.

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Multimedia developer''s guide

在预测无症状成年人的心血管事件方面,基于非增强CT腹主动脉钙化定量分析是否优于弗雷明汉风险评分?

1994年

作者： perry Paul j.

来源：畅想之星图书光盘版（南... 评论

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国际医学放射学杂志 2019年第2期42卷 229-230页

作者： S.D.O'Connor P.M.Graffy R.Zea P.j.pickhardt 徐思 Department of Radiology University of Wisconsin School of Medicine and Public Health

目的确定CT上的腹主动脉钙化(AAC)能否预测心血管事件而不依赖于弗雷明汉风险评分(FRS)。材料与方法在这项回顾性研究中,对2004年4月—2005年3月期间接受CT平扫结肠成像筛查的829例无症状病人(平均年龄57.9岁;女451例,男378例)的电子健... 详细信息

目的确定CT上的腹主动脉钙化(AAC)能否预测心血管事件而不依赖于弗雷明汉风险评分(FRS)。材料与方法在这项回顾性研究中,对2004年4月—2005年3月期间接受CT平扫结肠成像筛查的829例无症状病人(平均年龄57.9岁;女451例,男378例)的电子健康记录进行了后续心血管事件的回顾性研究;平均随访间隔为(11.2±2.8)年。研究获得机构伦理委员会的批准。

关键词：心血管 AAC 风险评分无症状腹主动脉定量分析 CT

维普期刊数据库

常规腹部和胸部CT的机会性骨质疏松筛查:超过2万成人的正常L1骨小梁CT值

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国际医学放射学杂志 2019年第4期 479-480页

作者：梁译丹 S.jang P.M.Graffy T.j.Ziemlewicz S.j.Lee R.M.Summers P.j.pickhardt Department of Radiology University of Wisconsin School of Medicine and Public Health E3/311 Clinical Science Center

摘要目的确定成人第一腰椎(L1)骨小梁CT值的参考范围,在常规CT上测量骨密度(BMD)。材料与方法收集120 kV条件下进行的20 374次腹部和/或胸部的成人CT检

关键词：骨质疏松骨小梁 CT L1