Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways

作     者：Chao Li Li Tao Guobo Guan Zhangyue Guan Austin M.Perry Tianren Hu Jian Bing Ming Xu Clarissa J.Nobile Guanghua Huang 

作者机构：Department of Infectious DiseasesHuashan HospitalShanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic EngineeringSchool of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of MycologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Molecular and Cell BiologyUniversity of CaliforniaMercedMerced CA 95343USA Quantitative and Systems Biology Graduate ProgramUniversity of CaliforniaMercedMerced CA 95343USA Health Sciences Research InstituteUniversity of CaliforniaMercedMerced CA 95343USA Shanghai Engineering Research Center of Industrial MicroorganismsShanghai 200438China Shanghai Huashen Institute of Microbes and InfectionsShanghai 200052China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2023年第66卷第8期

页      面：1915-1929页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2021YFC2300400) the National Natural Science Foundation of China(31930005 and 32170194) Shanghai Municipal Science and Technology Major Project(HS2021SHZX001) supported by the National Institutes of Health(NIH)National Institute of General Medical Sciences(NIGMS)award R35GM124594 by the Kamangar family in the form of an endowed chair to C.J.N 

主　　题：atmospheric relative humidity sexual reproduction same-sex mating Candida albicans trehalose metabolism osmotic stress 

摘      要：Sexual reproduction is prevalent in eukaryotic organisms and plays a critical role in the evolution of new traits and in the generation of genetic *** factors often have a direct impact on the occurrence and frequency of sexual reproduction in *** regulatory effects of atmospheric relative humidity(RH)on sexual reproduction and pathogenesis in plant fungal pathogens and in soil fungi have been extensively ***,the knowledge of how RH regulates the lifecycles of human fungal pathogens is *** this study,we report that low atmospheric RH promotes the development of mating projections and same-sex(homothallic)mating in the human fungal pathogen Candida *** RH causes water loss in *** cells,which results in osmotic stress and the generation of intracellular reactive oxygen species(ROS)and *** water transporting aquaporin Aqy1,and the G-protein coupled receptor Gpr1 function as cell surface sensors of changes in atmospheric *** of the trehalose metabolic pathway by inactivating trehalose synthase or trehalase promotes same-sex mating in *** by increasing osmotic or ROS stresses,*** trehalose and ROS signal the Hog1-osmotic and Hsf1-Hsp90 signaling pathways to regulate the mating ***,therefore,propose that the cell surface sensors Aqy1 and Gpr1,intracellular trehalose and ROS,and the Hog1-osmotic and Hsf1-Hsp90 signaling pathways function coordinately to regulate sexual mating in response to low atmospheric RH conditions in ***.