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Altered spontaneous brain activity in patients with diabetic optic neuropathy:A resting-state functional magnetic resonance imaging study using regional homogeneity

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World Journal of Diabetes 2021年第3期12卷 278-291页

作者： Gui-Ying Guo Li-Juan Zhang Biao Li Rong-Bin Liang Qian-Min Ge Hui-Ye Shu Qiu-Yu Li Yi-Cong Pan Chong-gang pei Yi Shao Department of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetes is a common chronic *** the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased *** DON leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains *** To investigate the local characteristics of spontaneous brain activity using regional homogeneity(ReHo)in patients with *** We matched 22 patients with DON with 22 healthy controls(HCs).All subjects underwent resting-state functional magnetic resonance *** ReHo technique was used to record spontaneous changes in brain *** operating characteristic(ROC)curves were applied to differentiate between ReHo values for patients with DON and *** also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation *** ReHo values of the right middle frontal gyrus(RMFG),left anterior cingulate(LAC),and superior frontal gyrus(SFG)/left frontal superior orbital gyrus(LFSO)were significantly lower in DON patients compared to *** these,the greatest difference was observed in the *** result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON,and the RMFG and LAC ReHo values are more clinically relevant than SFG/*** also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values(r=-0.9336,P<0.0001 and r=-0.8453,P<0.0001,respectively).CONCLUSION Three different brain regions show ReHo changes in DON patients,and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.

关键词： Diabetes Diabetic optic neuropathy Regional homogeneity Resting state Functional magnetic resonance imaging Brain activity

Induction of apoptosis and change of bcl-2 expression in macrophage Ana-1 cells by all-trans retinoic acid

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Cell Research 1996年第2期6卷 137-144页

作者： YIN DE LING XIU HAI REN SHI ZHONG BU YA LAN WU LI ZHEN JIANG ZHI JIANG WU WEI HU gang pei (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China)(Correspondence: Dr. G. pei, Shanghai Institute of Cell Biology Chine Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai 200031 China.

Macrophage cells play an important role in the initiation and regulation of the immune response. All-trans retinoic acid (ATRA) and its natural and synthetic analogs (retinoids) affect a large number of biological *** , retinoids have been shown promise in the therapy and prevention of various cancers. However, many interesting questions related to the activities of retinoids remain to be answered: (Ⅰ) Molecular mechanisms by which retinoids exert their effects; (Ⅱ) why the clinical uses of retinoids give undesirable side effects of varying severity with a higher freqllency of blood system symptoms; (Ⅲ)little is known for its impacts on macrophage cells etc. We set up this experiment, therefore, to examine the apoptosis of ATRA on macrophage Ana-1 cell line. Apoptosis of the cells was quantitated, after staining cells with propidium iodide (PI), by both accounting nuclear condensation and flow cytometry. When the cells were treated with ATRA at or higher than 1 μM for more than 24 h, significant amount of the apoptotic cells was observed. Induction of apoptosis of Ana-1 cells by ATRA was in time- and dose-dependent manners, exhibiting the similar pattern as the apoptosis induced by actinomycin D (ACTD). ATRA treatment of Ana-1 cells also caused the changes of the mRNA levels of apoptosis-associated gene bcl-2, as detected by Northern blot analysis. The temporal changes of bcl-2 expression by ATRA was also parallel to that by ACTD. In conclusion,ATRA can induce apoptosis in macrophage cells, which may be helpful in understanding of immunological functions retinoids.

关键词： All-trans retinoic acid apoptosis Ana-1 cells bcl-2

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新型光伏-太阳能环形热管/热泵复合系统

化工学报 2014年第8期65卷 3228-3236页

作者：张龙灿裴刚张涛季杰中国科学技术大学热科学和能源工程系安徽合肥230026 北京航天长征飞行器研究所北京100076

光伏-太阳能环形热管/热泵复合系统将太阳能环形热管循环模式和太阳能热泵循环模式有机结合,两者采用相同的工质,共用一个PVT蒸发器和冷凝器。当太阳辐照强度较强,工质在PVT蒸发器中的温度高于冷凝器中的温度时,可以利用环形热管模式制... 详细信息

光伏-太阳能环形热管/热泵复合系统将太阳能环形热管循环模式和太阳能热泵循环模式有机结合,两者采用相同的工质,共用一个PVT蒸发器和冷凝器。当太阳辐照强度较强,工质在PVT蒸发器中的温度高于冷凝器中的温度时,可以利用环形热管模式制热;当太阳辐照强度较弱或工质在PVT蒸发器中与冷凝器中的温差无法满足环形热管模式运行时,可以利用热泵模式制热。两种模式既能够独立运行,又可以互相切换,确保热能的稳定供应,同时能够明显降低系统耗电量。搭建了光伏-太阳能环形热管/热泵复合系统实验平台,对复合系统在环形热管模式和热泵模式独立运行时的瞬时性能和全天性能进行了实验研究。

关键词：太阳能热泵环形热管热力学可用能

Antihepatoma peptide,scolopentide,derived from the centipede scolopendra subspinipes mutilans

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World Journal of Gastroenterology 2023年第12期29卷 1875-1898页

作者： Yu-Xing Hu Zhuo Liu Zhen Zhang Zhe Deng Zhen Huang Ting Feng Qing-Hong Zhou Si Mei Chun Yi Qing Zhou Pu-Hua Zeng gang pei Sha Tian Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Scientific Research Hunan Academy of Traditional Chinese Medicine Affiliated HospitalChangsha 410208Hunan ProvinceChina Hunan Province University Key Laboratory of Oncology of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Pediatric Shenzhen Hospital of Beijing University of Chinese MedicineShenzhen 518000Guangdong ProvinceChina Department of Physiology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Pathology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Andrology First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Oncology Hunan Academy of Traditional Chinese Medicine Affiliated HospitalChangsha 410208Hunan ProvinceChina College of Pharmacy Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery Macao University of Science and TechnologyMacao 999078China

BACKGROUND Centipedes have been used to treat tumors for hundreds of years in ***,current studies focus on antimicrobial and anticoagulation agents rather than *** molecular identities of antihepatoma bioactive components in centipedes have not yet been extensively *** is a challenge to isolate and characterize the effective components of centipedes due to limited peptide purification technologies for animal-derived *** To purify,characterize,and synthesize the bioactive components with the strongest antihepatoma activity from centipedes and determine the antihepatoma *** An antihepatoma peptide(scolopentide)was isolated and identified from the centipede scolopendra subspinipes mutilans using a combination of enzymatic hydrolysis,a Sephadex G-25 column,and two steps of high-performance liquid chromatography(HPLC).Additionally,the CCK8 assay was used to select the extracted fraction with the strongest antihepatoma *** molecular weight of the extracted scolopentide was characterized by quadrupole time of flight mass spectrometry(QTOF MS),and the sequence was matched by using the Mascot search *** on the sequence and molecular weight,scolopentide was synthesized using solid-phase peptide synthesis *** synthetic scolopentide was confirmed by MS and *** antineoplastic effect of extracted scolopentide was confirmed by CCK8 assay and morphological changes again in *** antihepatoma effect of synthetic scolopentide was assessed by the CCK8 assay and Hoechst staining in vitro and tumor volume and tumor weight in *** the tumor xenograft experiments,qualified model mice(male 5-week-old BALB/c nude mice)were randomly divided into 2 groups(n=6):The scolopentide group(0.15 mL/d,via intraperitoneal injection of synthetic scolopentide,500 mg/kg/d)and the vehicle group(0.15 mL/d,via intraperitoneal injection of normal saline).The mice were euthanized by cervical dislocation after 14 d of con

关键词： Scolopendra Centipede Antihepatom peptide Hepatocellular carcinoma Death receptor 4 Death receptor 5

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灭火及应急救援远程战略投送体系建设

消防科学与技术 2012年第8期31卷 859-863页

作者：宋培刚莆田市消防支队福建莆田351100

针对当前日趋严峻的重特大灾害事故处置需要,从消防部队"灭大火、救大灾"的要求出发,结合我国经济区域建设和发展趋势,阐述了我国构建重大灾害事故灭火及应急救援远程战略投送体系的现实意义,探讨运用动态立体灭火救援圈理论,构建重特... 详细信息

针对当前日趋严峻的重特大灾害事故处置需要,从消防部队"灭大火、救大灾"的要求出发,结合我国经济区域建设和发展趋势,阐述了我国构建重大灾害事故灭火及应急救援远程战略投送体系的现实意义,探讨运用动态立体灭火救援圈理论,构建重特大灾害事故灭火和抢险救援远程战略投送体系及其现实应用的基本思路。

关键词：消防应急救援灭火救援圈

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多语际语音迁移实例研究及启示

山东外语教学 2010年第4期31卷 46-49页

作者：裴光钢山东师范大学外国语学院

本文采用定性研究的方式，以西班牙语专业大学生为研究对象，对其在母语和第一外语英语影响下的西班牙语学习过程中出现的语言迁移现象；运用语言对比法研究汉、英、西三种语言的语音规律和特点；使用Audio Recorder Deluxe软件采样展... 详细信息

本文采用定性研究的方式，以西班牙语专业大学生为研究对象，对其在母语和第一外语英语影响下的西班牙语学习过程中出现的语言迁移现象；运用语言对比法研究汉、英、西三种语言的语音规律和特点；使用Audio Recorder Deluxe软件采样展开研究。重点对多语际语音教学实践中的几个方面加以研究分析：（1）多语际语音学习中各语音之间的语言迁移作用的关系；（2）多语际语音教学中语言迁移现象的特点和规律；（3）多语际语言迁移的作用的影响及对语音教学的启示。分析母语和英语语音基础对学习者学习第二外语所产生的作用和影响，可以为三语习得及外语教学提供有价值的借鉴和经验。

关键词：多语际母语语音语言迁移

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低温对迈克尔逊干涉仪干涉调制度的影响

光子学报 2009年第4期38卷 967-970页

作者：梁宏王培纲中国科学院上海技术物理研究所上海200083

为使干涉仪能在低温下正常可靠的工作,从低温下波面畸变、动镜倾斜及分束器的性能变化几个方面讨论了低温对干涉调制度的影响.介绍了减小低温对干涉调制度影响的措施,为确定傅里叶光谱仪干涉系统光学机械零件的材料、加工准确度、装夹... 详细信息

为使干涉仪能在低温下正常可靠的工作,从低温下波面畸变、动镜倾斜及分束器的性能变化几个方面讨论了低温对干涉调制度的影响.介绍了减小低温对干涉调制度影响的措施,为确定傅里叶光谱仪干涉系统光学机械零件的材料、加工准确度、装夹方式、装调要求以及干涉仪的动态控制准确度等提供了参考依据.

关键词：低温迈克尔逊干涉仪干涉调制度傅里叶光谱仪

Functional expression of opioid receptor-like receptorand its endogenous specific agonist nociceptin/orphanin FQ during mouse embryogenesis

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Cell Research 1997年第2期7卷 207-215页

作者： WU YA LAN GUO HUANG FAN JIAN ZHAO YIZHANG TIAN HUA ZHOU LAN MA gang pei(Shanghai Institute of Cell Biology, Chinese Academy ofSciences, Shanghai 200031, ChinaShanghai Medical University, Shanghai 200032, China) Shanghai Medical University Shanghai 200032 China

Expression of opioid receptor-like receptor (ORL1)and its endogenous peptide agonist nociceptin/orphaninFo (N/OFQ) during mouse embryogenesis have been investigated. Transcripts of ORL1 and N/OFQ were detected by RT-PCR in mouse brain of day 8 embryo (E8)and the expression continued afterwards. Northern blotanalysis revealed abundant expression of ORL1 at postnatal day 1 (P1) and N/OFQ at E17 and P1 in the brain butnone was detected in other embryonic tissues. The presence of functional ORL1 in mouse embryonic brain wasalso confirmed by specific binding of [3H] N/OFQ (kd=1.3±0.5 nM and Bmax = 72±9 fmol/mg protein) as wellas by N/OFQ-stimulated G protein activation.

关键词： Opioid receptor-like receptor (ORL1) nociceptin/orphanin FQ (N/OFQ) mouse embryogenesis functional expression

科研院所激励机制问题与对策研究——以天津天士力集团研究院为例

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科学学研究 2003年第z1期21卷 114-119页

作者：冯培刚林生北京市工商局北京100081 钢铁研究总院北京100081

本文用双因素组合激励模型对天士力研究院的激励机制的现状进行了分析,并对研究院的考核评估机制进行研究,提出研究院目前的激励和考评机制中存在的问题,针对这些问题提出提高天士力集团研究院考核激励效果的建议方案。

关键词：天士力研究院激励机制考核评估