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Biosensing with free space whispering gallery mode microlasers

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Photonics Research 2023年第5期11卷 732-741页

作者： ANGELA CAPOCEFALO SILVIA GENTILINI LORENZO BAROLO paola BAIOCCO CLAUDIO CONTI NEDA GHOFRANIHA Istituto dei Sistemi Complessi-CNR UOS UniversitàLa SapienzaI-00185 RomeItaly Dipartimento di Scienze Biochimiche A.Rossi Fanelli UniversitàLa SapienzaI-00185 RomeItaly Dipartimento di Fisica UniversitàLa SapienzaI-00185 RomeItaly

Highly accurate biosensors for few or single molecule detection play a central role in numerous key fields,such as healthcare and environmental *** the last decade,laser biosensors have been investigated as proofs of concept,and several technologies have been *** here propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins,down to 400 *** have the advantage of working in free space without any need for waveguiding for input excitation or output signal *** photonic microsensors can be easily patterned on microscope slides and operate in air and *** estimate the limit of detection up to 148 nm/RIU for three different protein *** addition,the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.

关键词： passive mode excitation

On predicting and improving the quality of Volunteer Geographic Information projects

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International Journal of Digital Earth 2016年第2期9卷 134-155页

作者： Gloria Bordogna paola Carrara Laura Criscuolo Monica Pepe Anna Rampini CNR IREANational Research Council of ItalyInstitute for Environmental Remote SensingMilanoItaly

Initiatives that rely upon the contributions of volunteers to reach a specific goal are growing more and more with the success of Web 2.0–interactive *** scientific projects are testing and exploiting volunteers’collaboration,but the quality of information obtained with this approach is often *** paper offers a rich overview of many scientific projects where geographic contributions are committed to volunteers,to the aim of defining strategies to improve information *** describing real examples of Volunteer Geographic Information(VGI),the contribution establishes a categorization based on the characteristics of the information,tasks,and scopes of the *** a discussion on the relationships of categories and VGI quality,the paper analyses techniques to improve the quality of volunteered information according to the moment of its assessment(i.e.,ex ante,ex post,or both with respect to information creation).The paper outlines the main limitations of the different approaches and indicates some guidelines for future developments.

关键词： Volunteered Geographic Information Citizen Science information quality quality improvement

The translational revolution in atopic dermatitis:the paradigm shift from pathogenesis to treatment

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Cellular & Molecular Immunology 2023年第5期20卷 448-474页

作者： paola Facheris Jane Jeffery Ester Del Duca Emma Guttman-Yassky Laboratory of Inflammatory Skin Diseases Department of DermatologyIcahn School of Medicine at Mount SinaiNew YorkNYUSA Humanitas Clinical and Research Center Department of DermatologyRozzanoMilanoItaly Duke University School of Medicine DurhamNCUSA Department of Dermatology Icahn School of Medicine at Mount SinaiNew YorkNYUSA.

Atopic dermatitis(AD)is the most common inflammatory skin disease,and it is considered a complex and heterogeneous *** phenotypes of AD,defined according to the patient age at onset,race,and ethnic background;disease duration;and other disease characteristics,have been recently described,underlying the need for a personalized treatment *** advancements in understanding AD pathogenesis resulted in a real translational revolution and led to the exponential expansion of the therapeutic *** study of biomarkers in clinical studies of emerging treatments is helping clarify the role of each cytokine and immune pathway in AD and will allow addressing the unique immune fingerprints of each AD *** medicine will be the ultimate goal of this targeted translational *** this review,we discuss the changes in the concepts of both the pathogenesis of and treatment approach to AD,highlight the scientific rationale behind each targeted treatment and report the most recent clinical efficacy data.

关键词： Atopic dermatitis translational revolution biomarkers eczema

A Clustering Algorithm for Planning the Integration Process of a Large Number of Conceptual Schemas

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Journal of Computer Science & Technology 2015年第1期30卷 214-224页

作者： Carlo Batini: paola Bonizzoni Marco Comerio Riccardo Dondi Yuri Pirola Prancesco Salandra Department of Informatics Systems and Communication University of Milano-Bicocca Milan 20126 Italy Department of Human and Social Sciences University of Bergamo Bergamo 24129 Italy

When tens and even hundreds of schemas are involved in the integration process, criteria are needed for choosing clusters of schemas to be integrated, so as to deal with the integration problem through an efficient iterative process. Schemas in clusters should be chosen according to cohesion and coupling criteria that are based on similarities and dissimilarities among schemas. In this paper, we propose an algorithm for a novel variant of the correlation clustering approach that addresses the problem of assisting a designer in integrating a large number of conceptual schemas. The novel variant introduces upper and lower bounds to the number of schemas in each cluster, in order to avoid too complex and too simple integration contexts respectively. We give a heuristic for solving the problem, being an NP hard combinatorial problem. An experimental activity demonstrates an appreciable increment in the effectiveness of the schema integration process when clusters are computed by means of the proposed algorithm w.r.t, the ones manually defined by an expert.

关键词： conceptual schema schema integration clustering

Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk

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World Journal of Gastroenterology 2011年第26期17卷 3082-3091页

作者： Lucia Pacifico Valerio Nobili Caterina Anania paola Verdecchia Claudio Chiesa Department of Pediatrics Sapienza University of Rome Department of Hepato-gastroenterology and Nutrition Pediatric Hospital "Bambino Gesù" Institute of Translational Pharmacology National Research Council

Nonalcoholic fatty liver disease(NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol *** mildest form is simple steatosis in which triglycerides accumulate within hepatocytes.A more advanced form of NAFLD,nonalcoholic steatohepatitis,includes inflammation and liver cell injury,progressive to cryptogenic *** has become the most common cause of chronic liver disease in children and *** recent rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic *** is strongly associated with abdominal obesity,type 2 diabetes,and dyslipidemia,and most patients have evidence of insulin ***,NAFLD shares many features of the metabolic syndrome(MetS),a highly atherogenic condition,and this has stimulated interest in the possible role of NAFLD in the development of *** evidence suggests thatNAFLD is associated with a significantly greater overall mortality than in the general population,as well as with increased prevalence of cardiovascular disease(CVD),independently of classical atherosclerotic risk ***,several studies including the pediatric population have reported independent associations between NAFLD and impaired flow-mediated vasodilatation and increased carotid artery intimal medial thickness-two reliable markers of subclinical atherosclerosis-after adjusting for cardiovascular risk factors and ***,the rising prevalence of obesity-related MetS and NAFLD in childhood may lead to a parallel increase in adverse cardiovascular *** children,the cardiovascular system remains plastic and damage-reversible if early and appropriate interventions are established *** goals for NAFLD should address nutrition,physical activity,and avoidance of smoking to prevent not only end-stage liver disease but also CVD.

关键词： Nonalcoholic fatty liver disease Metabolicsyndrome Cardiovascular risk Children

Performance Measurement in the Social Sector:Recent Trends in the Impact Assessment Process

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Performance Measurement in the Social Sector:Recent Trends i...

作者： paola MAPELLI 复旦大学

学位级别：硕士

从社会创业精神的概念开始,在社会部于于的组织机构面对许多由于最近的扩张阶段现象,和缺乏标准处理方法而引起的挑战。专注于绩效衡量,文献回顾,在深入分析统一的方法后,暴露了组织机构在搜索并运用适当的影响评估工具来配合最佳工作... 详细信息

从社会创业精神的概念开始,在社会部于于的组织机构面对许多由于最近的扩张阶段现象,和缺乏标准处理方法而引起的挑战。专注于绩效衡量,文献回顾,在深入分析统一的方法后,暴露了组织机构在搜索并运用适当的影响评估工具来配合最佳工作积极性的困难。此外,社会价值的创造往往很难衡量,因为它经常是无形的。通过混合方法的途径,定性和定量分析管理,以解决影响评估方面最新趋势的三个研究问题：组织机构用哪些工具衡量绩效?他们如何沟通取得的成果?是否有一个最佳做法吗?该研究始于对五个咨询公司和非营利组织代表的深度访谈的基础上。为确认访谈的结果,15个社会部(?)的组织机构进行了一项针对青年的调查。最后一个案例研究,午夜篮球(由劳伦斯基金会为年轻人做的一个运动风险项目),显示了一个最佳实践的例子.总之,结果表明,社会部(?)的组织机构认识到影响评估和沟通结果的重要性。即使他们面临着一些挑战,他们愿意找到并应用更多的标准工具,如SROI和CBA,通过生成的报表和演示文稿来沟通.本篇论文旨在分析研究社会区域的绩效衡量,分析说明社会影响衡量的重要性以及关于结果的交流,以便于改正行动和扩散社会创业的概念.

关键词： sector 社会部组织机构社会创业 questionnaire communicate 最佳做法 behaviour 绩效衡量 return

L-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

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Protein & Cell 2018年第4期9卷 322-332页

作者： Cecile Apert paola Romagnoli Joost P, M. van Meerwijk CPTP Universite de Toulouse CNRS Inserm UPS Toulouse France

Immunosuppressive regulatory T lymphocytes （Treg） expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 （IL-2） and IL-15. The more recently appreciated involvement of TGF-β in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.

关键词： regulatory T cells thymus differentiation,IL-2 IL-15

Tumor-associated myeloid cells:diversity and therapeutic targeting

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Cellular & Molecular Immunology 2021年第3期18卷 566-578页

作者： Alberto Mantovani Federica Marchesi Sebastien Jaillon Cecilia Garlanda paola Allavena Department of Immunology and Inflammation Humanitas Clinical and Research Center-IRCCSRozzanoItaly Department of Biomedical Science Humanitas UniversityRozzanoItaly The William Harvey Research Institute Queen Mary University of LondonLondonUK Department of Biotechnology and Translational Medicine University of MilanMilanItaly

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional *** tumor-associated macrophages(TAMs),which are more abundantly represented,and tumor-associated neutrophils(TANs)are known to sustain tumor cell growth and invasion,support neoangiogenesis and suppress anticancer adaptive immune *** recent decades,several therapeutic approaches have been implemented in preclinical cancer models to neutralize the tumor-promoting roles of both TAMs and *** of the most successful strategies have now reached the clinic and are being investigated in clinical *** this review,we provide an overview of the recent literature on the evergrowing complexity of the biology of TAMs and TANs and the development of the most promising approaches to target these populations therapeutically in cancer patients.

关键词： tumor-associated macrophages tumor microenvironment macrophage targeting

Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent

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World Journal of Gastroenterology 2006年第14期12卷 2187-2194页

作者： Nicola Dioguardi Fabio Grizzi Barbara Franceschini paola Bossi Carlo Russo Laboratori di Medicina Quantitativa Istituto Clinico Humanitas IRCCS RozzanoMilanand "Michele Rodriguez" FoundationInstitute for Quantitative Methods in MedicineMilanItaly Department of Pathology Istituto Clinico Humanitas IRCCS RozzanoMilanItaly

AIM： To provide the accurate alternative metrical means of monitoring the effects of new antiviral drugs on the reversal of newly formed collagen. METHODS： Digitized histological biopsy sections taken from 209 patients with chronic C virus hepatitis with different grade of fibrosis or cirrhosis, were measured by means of a new, rapid, user-friendly, fully computeraided method based on the international system meter rectified using fractal principles. RESULTS： The following were described： geometric perimeter, area and wrinkledness of fibrosis; the collation of the Knodell, Sheuer, Ishak and METAVIR scores with fractal-rectified metric measurements; the meaning of the physical composition of fibrosis in relation to the magnitude of collagen islets; the intra- and inter-biopsy sample variability of these parameters; the ＂staging＂ of biopsy sections indicating the pathway covered by fibrosis formation towards its maximum known value; the quantitative liver tissue architectural changes with the Hurst exponent. CONCLUSION： Our model provides the first metrical evaluations of the geometric properties of fibrosis and the quantitative architectural changes of the liver tissue. The representativeness of histological sections of the whole liver is also discussed in the light of the results obtained with the Hurst coefficient.

关键词： Liver Fibrosis Cirrhosis Staging Image analysis Fractals