Biosensing with free space whispering gallery mode microlasers

作     者：ANGELA CAPOCEFALO SILVIA GENTILINI LORENZO BAROLO PAOLA BAIOCCO CLAUDIO CONTI NEDA GHOFRANIHA 

作者机构：Istituto dei Sistemi Complessi-CNRUOS UniversitàLa SapienzaI-00185 RomeItaly Dipartimento di Scienze Biochimiche A.Rossi FanelliUniversitàLa SapienzaI-00185 RomeItaly Dipartimento di FisicaUniversitàLa SapienzaI-00185 RomeItaly 

出 版 物：《Photonics Research》 (光子学研究（英文版）)

年 卷 期：2023年第11卷第5期

页      面：732-741页

核心收录：

学科分类：0808[工学-电气工程] 080901[工学-物理电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080202[工学-机械电子工程] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：Rome Technopole(ECS00000024-Next Generation EU,CUP:B83C22002890005) Regione LAZIO Lazio-Innova POR FESR Lazio 2014-2020 European Commission(A0375-2020-36549,CUP:B85F20003340002) 

主　　题：passive mode excitation 

摘      要：Highly accurate biosensors for few or single molecule detection play a central role in numerous key fields,such as healthcare and environmental *** the last decade,laser biosensors have been investigated as proofs of concept,and several technologies have been *** here propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins,down to 400 *** have the advantage of working in free space without any need for waveguiding for input excitation or output signal *** photonic microsensors can be easily patterned on microscope slides and operate in air and *** estimate the limit of detection up to 148 nm/RIU for three different protein *** addition,the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.