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Navigating medial patellotibial ligament reconstruction:Clinical perspectives and surgical strategies

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World Journal of Clinical Cases 2025年第1期13卷 6-10页

作者： Juan pablo Zicaro Ignacio garcia-Mansilla Division of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when *** medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the *** this,both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of *** clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still *** editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers’understanding of this technique,especially because reported clinical outcomes have remained sparse.

关键词： Medial patellotibial ligament Patellar instability Reconstruction Surgical

Pleiotrophin fights Brd2 for neuronal differentiation

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Neural Regeneration Research 2015年第4期10卷 544-546页

作者： pablo garcia-Gutierrez Mario garcia-Dominguez Stem Cells department Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) (Consejo Superior de Investigaciones Cientificas (CSIC)Junta de AndalucíaUniversidad de SevillaUniversidad Pablo de Olavide).Av.Americo Vespucio s/n41092 SevilleSpain

Bromodomain containing 2 （Brd2） protein belongs to the Bromodomains and Extra Terminal domain （BET） family of chromatin adaptors characterized by the presence of two N-terminal tandem bromodomains and an exclusive C-terminal extra terminal domain （ET）（Belkina and denis, 2012; Shi and Vakoc, 2014）. Bromodomains are involved in recognizing acetylated histone tails and other acetylated proteins while the ET domain has been implicated in protein-protein interaction.

关键词： Pleiotrophin fights Brd2 for neuronal differentiation cycle

Episcleral brachytherapy as an effective alternative in vasoproliferative tumors

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 2017-2020页

作者： Marta Para Prieto Maria Antonia Saornil Jesus Maria de frutos Baraja Ciro garcia Alvarez Patrieia Diezhandino garcia Francisco Lopez Lara Intraocular Tumors Unit Ophthalmology &Radiotherapy departmentsHospital Clinico UniversitarioValladolid 47005 Spain

The aim of this study is to assess the results of episcleral brachytherapy as treatment of retinal vasoproliferative tumors(RVTs) in a referral Intraocular Tumors Unit(ITU). A retrospective review of all patients diagnosed with vasoproliferative tumors of the retina and treated with episcleral brachytherapy in the ITU, University Hospital of Valladolid between 2009 and 2015 was done. Five patients accomplished the inclusion criteria. All of them presented associated exudation and secondary retinal detachments(RD). Four patients had received prior treatments. decreased tumor size and exudation regression was found in all cases after treatment. Visual acuity remained stable or increased in all patients. No recurrences have been found after twelve-months follow up. The results of the present study suggest that episcleral brachytherapy is an efficient and safe option in the management of vasoproliferative tumors, especially when large tumor or extensive subretinal fluid is present. In these cases episcleral brachytherapy could be considered as a first line treatment.

关键词： episcleral brachytherapy retinal vasoproliferative tumors

Planetary Gear Profile Modification design Based on Load Sharing Modelling

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 810-820页

作者： IGLESIAS Miguel FERNáNdeZ deL RINCóN Alfonso de-JUAN Ana Magdalena garcia pablo DIEZ Alberto VIAdeRO Fernando Mechanical Engineering Research Group University of Cantabria

In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications.

关键词： transmission planetary gear load sharing relief profile modification

Impact of surface roughness on the coefficient of friction of polymer-on-polymer contacts for deflection pulley-rope systems in the lift industry

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Friction 2024年第9期12卷 2126-2138页

作者： Ainhoa GUINEA Andrea AGINAGALde Wilson TATO Iñigo LLAVORI pablo garcia Leire ARRAIAGO Alaitz ZABALA Mechanical and Industrial Production department Mondragon UnibertsitateaMondragon 20500Spain Orona EIC Orona IdeoHernani 20120Spain

The coefficient of friction(CoF)between the deflection pulley and rope in a lift strongly affects the life span of the *** surface roughness is a key factor affecting the metallic pulley–rope CoF,its effect on polymeric pulleys is *** present study analyses the effect of roughness and working conditions on cast polyamide 6(PA6G)deflection pulley–thermoplastic polyurethane(TPU)-coated rope *** statistical analysis revealed that the effect of surface roughness on the CoF for low-load tests was *** present study contributes significantly to parameter selection in deflection pulley machining to minimise friction between the pulley and rope.

关键词： polymer-on-polymer friction roughness dry sliding

A GIS-based methodology for the appraisal of historical,architectural,and social values in historic urban cores

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Frontiers of Architectural Research 2020年第4期9卷 900-913页

作者： Juan A.garcia-Esparza pablo Altaba Tena department of Mechanical Engineering and Construction Universitot Jaume I12071Castello de la PlanaSpain

Historic environments represent the evolution of materials and techniques that have been used for the construction these environments over the *** into the study of this field entails working not only on the crafts that have constructed these environ ments but also on the people who made,used,and reinterpreted them by learning about the craftsmen and the idiosyncrasies of the *** study has adopted several methodologies as referenee to examine the material and cultural reality of the rural region of Valencia,*** the adaptation of in ter national methodologies,researchers have carried out a digital database that compiles and maps out the results of the Local Character Assessment of ten Histotiric Urban Cores by incorporating the historical,architectural,and social values to reinforce the Territorial Heritage Action *** of the critical innovations adopted by this form of assessment is the compulsory integration of tangible and intangible heritage through the active involvement of users and *** innovation is to understand the values behind the dynamism and transformation of historic ***,this study advances theory and practice on the transmission of knowledge among artisans,researchers,and the population and how con temporary practices help acquire new meani ngs that overlap the past ones.

关键词： Historic environment Local Character Assessme nt Digital heritage GIS for heritage Heritage values

Insects as alternative feed for ruminants:comparison of protein evaluation methods

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1143-1150页

作者： pablo G.Toral Gonzalo Hervás Mariana Gabriela González-Rosales Alejandro G.Mendoza Lizbeth E.Robles-Jiménez Pilar frutos Instituto de Ganadería de Montaña(CSIC-University of León) Finca Marzanas s/n24346 GrullerosLeónSpain Facultad de Medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de MéxicoNo.100 Instituto Literario 100Col.Centro50000 TolucaEstado de MéxicoMexico.

Background:The high dependence of intensive ruminant production on soybean meal and the environmental impact of this crop encourage the search for alternative protein-rich *** use of insects seems promising,but the extent of their ruminal protein degradation is largely *** parameter has major influence not only on N utilization efficiency but also on the environmental burden of ruminant *** addition,although assessing ruminal N degradation represents a key first step to examine the potential of new feeds,it is a challenging task due to the lack of a reference *** study was conducted to investigate the potential of 4 insects(Tenebrio molitor,Zophobas morio,Alphitobius diaperinus and Acheta domesticus)as alternative protein sources for ruminants,using 3 methodologies:1)a regression technique based on the in vitro relationship between gas production and ammonia-N concentration;2)a conventional in vitro technique of batch cultures of ruminal microorganisms,based on filtering the incubation residue through sintered glass crucibles;and 3)the in situ nylon bag *** in vitro intestinal digestibility of the non-degraded protein in the rumen was also *** meal was used as a reference ***:Comparison of evaluation methods(regression,in vitro and in situ)did not allow to reliably select a single value of ruminal N degradation for the studied substrates,but all techniques seem to establish a similar ranking,with good correlations between methods,particularly between regression and in situ *** of the methodology,nitrogen from the 4 insects(with contents ranging from 81 to 112 g/kg of dry matter)did not show high ruminal degradation(41–76%),this value being always lower than that of soybean ***,the in vitro intestinal digestibility of non-degraded N was relatively high in all feeds(≥64%).Conclusion:Overall,these results support the potential of the 4 studied insects as alternative feedstu

关键词： In situ In vitro Livestock Nitrogen degradation Sheep

Landscape genetics reveals inbreeding and genetic bottlenecks in the extremely rare short-globose cacti Mammillaria pectinifera (Cactaceae) as a result of habitat fragmentation

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Plant Diversity 2017年第1期39卷 13-19页

作者： Reyna Maya-garcia Santiago Arizaga pablo Cuevas-Reyes Juan Manuel Penaloza-Ramirez Victor Rocha Ramirez Ken Oyama Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo Mexico Escuela Nacional-de Estudios Superiores Unidad Morelia UNAM Antigua Carretera a Pdtzcuaro 8701 Colonia Ex-Hacienda de SanJose de la Huerta58190 Morelia Michoacan Mexico

Mammillaria pectinifera is an endemic, short-globose cactus species, included in the IUCN list as a threatened species with only 18 remaining populations in the Tehuacfin-Cuicatlan Valley in central Mexico. We evaluated the population genetic diversity and structure, connectivity, recent bottlenecks and population size, using nuclear microsatellites. M. pectinifera showed high genetic diversity but some evidence of heterozygote deficiency （F15）, recent bottlenecks in some populations and reductions in population size. Also, we found low population genetic differentiation and high values of connectivity for M. pectinifera, as the result of historical events of gene flow through pollen and seed dispersal. M. pectinifera occurs in sites with some degree of disturbance leading to the isolation of its populations and decreasing the levels of gene flow among them. Excessive deforestation also changes the original vegetation damaging the natural habitats. This species will become extinct if it is not properly preserved. Furthermore, this species has some ecological features that make them more vulnerable to disturbance such as a very low growth rates and long life cycles. We suggest in situ conservation to prevent the decrease of population sizes and loss of genetic diversity in the natural protected areas such as the Tehuacan-Cuicatlan Biosphere Reserve. In addition, a long-term ex situ conservation program is need to construct seed banks, and optimize seed germination and plant establishment protocols that restore disturbed habitats. Furthermore, creating a supply of living plants for trade is critical to avoid further extraction of plants from nature.

关键词： MammiUaria pectiniferaNuclear SSRGenetic diversityRecent bottlenecksEffective population size

Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 135-139页

作者： Roberto Gonzalez-Salinas Maria C garcia-Gutierrez Gerardo garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga pablo garcia-Solis David G garcia-Gutierrez Marco Vinicio garcia-Solis Manuel Saenz de Viteri Juan C Solis-S Biomedical Research department Autonomous University of QueretaroQueretaro 76170Mexico Retina department Asociation to Prevent Blindness in MexicoMexico City 04030Mexico Research department Asociation to Prevent Blindness in MexicoMexico City 04030Mexico Retina department General Hospital of Queretaro(ISSSTE)Queretaro 76000Mexico Universidad La Salle School of Medicine Mexico City 06140Mexico

AIM： To assess if the included vascular endothelial growth factor （VEGF） polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus （T2DM）. METHODS： A case-control study was conducted in adult individuals with T2DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study （ETDRS） standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by qPCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype ***： In total 142 individuals were enrolled, 71 individuals with T2DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher’s exact test was performed for rs3025021 [OR （95% CI）=0.44（0.08-2.2）; P=0.25] and rs2010963 [OR （95% CI）=0.63（0.25-1.6）; P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows： rs3025021 vs rs3025035： D’=1.0, r2=0.1043, P≤0.0001; rs3025021 vs rs2010963： D’=0.442, r2=0.0446, P=0.149; rs3025035 vs rs2010963： D’=0.505, r2=0.0214, P=***： This is the first analysis involving VEGF polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that differ

关键词： vascular endothelial growth factor polymor-phism proliferative diabetic retinopathy non-proliferative diabetic retinopathy rs3025021 rs3025035 rs2010963