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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 319-323页

作者： Adejoke Elizabeth Memudu Ibukun Dorcas Akinrinade olalekan Michael Ogundele Department of Anatomy College of Medicine Bingham University Neural Systems Lab Department of Comparative Biomedical Sciences Louisiana State University

Objective: To investigate the effects of acute and chronic aqueous garlic extract ingestion on testicular cellular integrity and serum testosterone ***: Twenty(20) male Sprague-Dawley rats weighing an average of 120 g were *** were divided into three groups. Group A served as control(10 rats for 28 and 56 d respectively), while treatment Groups B and C were given 200 mg/kg for Allium sativum(garlic cloves) extract for 28 and 56 d ***: Histological analysis revealed the presence of all spermatogenic lineages, appearance of proliferative activities in the interstitial cells, as well as increased serum testosterone ***: This study confirmed proliferative and restorative potentials in both acute and chronic garlic ingestion.

关键词： Allium sativum Testis Testosterone

30,000 bpd Capacity Modified Modular Refinery Operations in Nigeria

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Open Journal of Modelling and Simulation 2022年第4期10卷 340-348页

作者： Adeloye olalekan Michael Department of Chemical/Petrochemical Engineering Rivers State University Port Harcourt Nigeria

The study investigated and classified twenty Nigerian crude oil types based on their products recovery volume at true boiling point temperature of 370˚C using crude oil assay analysis data into Group A (crude oil with recovery volume above 80%), Group B (crude oil with recovery volume between 70% and 79%) and Group C (crude oil with recovery volume below 70%) respectively. Thus, twenty Nigerian crude oil types were simulated in a modified modular refinery (modified topping plant) of 30,000 bpd capacity and twenty-nine (29) column trays number using Aspen Hysys software. Furthermore, the residues from the conventional modular refinery were processed as feedstock or precursor into the hydrocracker reactor attached to the stripping section of the modified modular refinery to yield more valuable products of liquefied petroleum gas, naphtha, diesel and bottom (residue). The simulation results of the modified modular refinery were compared with conventional modular refinery in terms of their residual yield percentage as Nigerian Brass 2012 of API 40.62, recovery volume 88.78%, yielded residue of 11.22% and 1.29% for conventional modular and modified modular refineries respectively while Okoro 2012 of least API 23.54, recovery volume 57.84%, yielded residue of 42.16% and 4.92% for conventional modular and modified modular refineries respectively. Thus, the residual or bottom product issue associated with operational process of conventional modular refinery operations in Nigeria due to inefficient or non-operational conventional major refinery in Nigeria has been resolved to minimum or least amount with the operational process of modified modular refinery operations in Nigeria.

关键词： Modified Modular Refinery Hydrocracker Topping Plant Residue Simulation Aspen Hysys

Photo enhanced degradation of contaminants of emerging concern in waste water

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Emerging Contaminants 2020年第1期6卷 283-302页

作者： olalekan C.Olatunde Alex T.Kuvarega Damian C.Onwudiwe Material Science Innovation and Modelling(MaSIM)Research Focus Area Faculty of Natural and Agricultural SciencesNorth-West UniversityMafikeng CampusPrivate Bag X2046Mmabatho2735South Africa Department of Chemistry School of Physical and Chemical SciencesFaculty of Natural and Agricultural SciencesNorth-West UniversityMafikeng CampusPrivate Bag X2046Mmabatho2735South Africa Nanotechnology and Water Sustainability Research Unit College of ScienceEngineering and TechnologyUniversity of South AfricaFlorida1709South Africa

Emerging contaminants are posing serious global threats to the environment due to their diversity,recalcitrant nature and *** disturbing is the fact that current wastewater treatment systems do not have the capacity to deal with these class of *** quest to develop new technologies to mitigate the adverse effects of these contaminants has engendered new research interest on photo-enhanced ***-enhanced processes,with the potential of mineralizing environmental pollutants,currently appears to be the main viable technology for dealing with emerging *** process of contaminant degradation could either proceed via oxidation or reduction routes,referred to as advanced oxidation processes(AOPs)and advanced reduction processes(ARPs)***,different processes have been incorporated into a single system in order to explore the synergy that ensue from the combination of these *** processes that are currently at the front line in dealing with various classes of emerging contaminants,whose presence in the environment continues to grow on a daily basis,are the focus of this review.

关键词： Photocatalysis Advanced oxidation processes Advanced reduction process Emerging contaminants Mineralization Waste water

Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil olalekan John Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes

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World Journal of Diabetes 2017年第7期8卷 337-345页

作者： Olusola olalekan Elekofehinti Oluwamodupe Cecilia Ejelonu Jean Paul Kamdem Oluwaseun Benedicta Akinlosotu Isaac Gbadura Adanlawo Department of Biochemistry University of Ado-Ekiti Department of Biochemistry Adekunle Ajasin University Departamento de Ciências Biológicas Universidade Regional do Cariri-URCA Campus Pimenta Department of Biochemistry Federal University of TechnologyAkure

Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we sum-marized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.

关键词： Adipokines Adipose tissue Insulin resistance Antidiabetic Obesity

Molecular Diversity of Fusarium oxysporum and Geotrichum candidum Isolated from Two Tomato Varieties Commonly Consumed in Some Southwestern Town in Nigeria

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American Journal of Plant Sciences 2022年第5期13卷 668-685页

作者： Ayodele Adegboyega Sobowale olalekan Ajibolade Ogunoye Department of Botany University of Ibadan Ibadan Nigeria Department of Crop Soil and Pest Management Technology Rufus Giwa Polytechnic Owo Owo Nigeria

Fusarium oxysporum and Geotrichum candidum, which are among important pathogens of Solanum lycopersicum L. (Tomato), are sometimes misidentified during morphological misidentification. The study was carried out to evaluate molecular diversity of F. oxysporum and G. candidum isolated from two tomato varieties obtained from Akure, Ilorin and Ibadan, Nigeria. The tomato samples were collected and brought back to the laboratory for fungal isolation. Isolation of the pathogens were done following standard procedures. DNA extraction from pure cultures of the pathogens was done at the Centre Laboratory of University of Ibadan. Genetic relationships among the organisms were also estimated by constructing a Dendrogram through UPGMA using the Mega6 Software and genetic distance was computed also using the Mega6 Software. Five strains of F. oxysporum and seven strains of G. candidum were identified. Percentage similarity of the pathogens with those in GenBank was 99.17% - 100.00% for F. oxysporum and 98.48% - 100.00% for G. candidum. The T-01 marker showed the lowest major allele frequency of 0.0833, while T-10 marker has the highest value for major allele frequency of 0.6667 and an average value of 0.3958. Evolutionary relationship showed that the two strains of G. candidum (MN650247 and MN650250) were similar. The three strains of F. oxysporum (MN650246 and MN650248, MN650245 and MN650253) were also similar. Genetic distances among pairs of the fungal strains ranged from 0.12 to 6.30 in pairwise fashion, with an average of 1.32. Evolutionary relationship or closeness among strains of a fungal species can thus be said not to depend on location.

关键词： Fusarium oxysporum Geotricum candidum Genetic Distances Evolutionary Relationship and Genes

The Incidence and Association of Mental Depression with Symptomatic Lumbar Degenerative Disc Disease and Treatment Outcome

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Health 2018年第11期10卷 1487-1497页

作者： Lukman olalekan Ajiboye Muhammad Oboirien Usmanu Danfodiyo University Teaching Hospital Sokoto Nigeria

Study Design: Prospective analytical study. Objectives: The aim was to determine the association between mental depression and symptomatic Lumbar Degenerative Disc Disease (LDDD) in patients with no previous background of mental disorder. We also aimed at determining the incidence of mental depressions in patients with LDDD and the effects of the treatment on the mental depression. Methodology: One hundred and sixty patients with no prior history of mental or behavioral disorders who presented with low back pains arising from LDDD and met inclusion criteria were studied. The clinical findings and Depression Screening Test pro-forma were completed for each. The extracted information was analyzed using Statistical Package for Social Science (SPSS) version 24.0. The statistical significance was set at P Results: One hundred and fifty-three patients completed the study, with a male to female ratio of 1:1.5 and the mean age of the patients was 48.5 years. The marital status was 4.4% single, 86.9% married, 3.8% divorce/separate and 5% widow/widower. Their levels of education were: no formal education (10.00%), primary school level (8.10%), secondary level (27.50%) and Tertiary level (54.40%). Conclusions: This study showed the incidence of mental depression in 32% of the patients with LDDD. We also noted a statistically significant relationship between symptomatic LDDD and level of mental depression with significant improvement in the level of depression at 6th month after treatment. Hence, assessment of the patients’ mental health is important in the management of LDDD.

关键词： Incidence Mental Depression Symptomatic Lumbar Degenerative Disc Disease Outcome Association

Optimization of the Striping Section of Modular Refinery Operations in Nigeria

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Open Journal of Optimization 2022年第3期11卷 15-31页

作者： Adeloye olalekan Michael Igbagara Princewill Woyinbrakemi Department of Chemical/Petrochemical Engineering Rivers State University Port Harcourt Nigeria Department of Chemical Engineering Federal University Otuoke Otuoke Nigeria

Nigerian crude oil type Okoro 2012 was applied in this study owing to its low API value 23.54 and high residual percentage value of 42.16% from conventional modular refinery operations in Nigeria. The residue acted as a precursor or feedstock to the hydrocracker reactor of the modified modular refinery operation, which is an hydrogenation catalytic process at operating conditions of 380°C and 183 bar respectively and the hydrogen gas applied is produced via steam-methane reforming since the operational feedstocks are available as methane is the first gaseous product from the modified modular refinery process. Thus, more valuable products such as liquefied petroleum gas, naphtha and diesel were produced from modified modular refinery thereby resolving the residue or bottom product issue associated with conventional modular refinery operation in Nigeria. Models were developed from the first principle through the application of the principle of conservation of mass to predict the performance of the hydrocracker reactor and the developed models were sets of ordinary differential equations, which were solved using MatLab ODE45 solver and validated using simulation data of Aspen Hysys software for the hydrocracker reactor. The results gave a minimum percentage absolute error (deviation) between model predictions and Aspen Hysys results of 4.45%, 5.0% and 2.02% for liquefied petroleum gas, naphtha and diesel products respectively. Hence, the model developed predicted the output performance of the hydrocracker reactor very closely and was applied in studying or simulation of the effects of catalyst effectiveness factor on the overall performance of the hydrocracker reactor.

关键词： Simulation Optimization Okoro 2012 Hydrocracker Five Lump Aspen Hysys MatLab

Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro

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Food Science and Human Wellness 2016年第1期5卷 17-23页

作者： Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson olalekan Agboola Aline Augusti Boligon Margareth Linde Athayde Biochemistry Unit Department of Biosciences and BiotechnologyKwara State UniversityMaleteP.M.B.1530IlorinNigeria Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeriaP.M.B.704Akure 340001Nigeria Department of Veterinary Physiology Biochemistry and PharmacologyUniversity of IbadanNigeria Phytochemical Research Laboratory Department of Industrial PharmacyFederal University of Santa MariaBuilding 26Room 1115Santa Maria CEP 97105-900Brazil

The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in ***(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric *** extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to *** extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent *** half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(Pkidney>*** extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liver>lungs>*** fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids.

关键词： peroxidation kidney inhibited

Preliminary Study of Groundwater Quality Using Hierarchical Classification Approaches for Contaminated Sites in Indigenous Communities Associated with Crude Oil Exploration Facilities in Rivers State, Nigeria

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Open Journal of Yangtze Oil and Gas 2022年第2期7卷 124-148页

作者： Morufu olalekan Raimi Henry Olawale Sawyerr Department of Community Medicine Environmental Health Unit Faculty of Clinical Sciences Niger Delta University Amassoma Bayelsa State Nigeria Department of Environmental Health Faculty of Pure and Applied Science Kwara State University Malete Kwara State Nigeria

Background: Groundwater is an important source of water. Since the control and removal of pollution are expensive, it is essential to identify the possible sources of contamination and to correctly classify groundwater on the basis of its intrinsic and integrated vulnerability. Objectives: To group ground water chemical ions and heavy metals parameters into similar groups. Method: The investigation made use of standard analytical procedures. All sampling, conservation, transportation and analysis followed standard procedures described in APHA (2012). To prevent degradation of the organic substances, all obtained samples were transferred to the laboratory, while kept in an icebox. Results: Sampling records from the same area are generally assigned to the same cluster during hierarchical cluster analysis (HCA). The cluster diagram shows the grouping of the heavy metal in the study area during wet and dry seasons. It reveals that 5 distinct clusters were identified for wet season and 4 clusters were identified during dry season. Also, it reveals that 5 distinct clusters were identified for wet season and for dry season, 4 distinct clusters were identified. Conclusion: The findings of this study are significant for policymakers and agencies in terms of dealing with the issues identified to enhance sustainable livelihood practices in the oil rich Niger Delta region of Nigeria. Therefore, decision-makers should take proper initiatives to get local people aware of the endangered zones before use, as drinking water is key to good health. Similarly, multinational oil companies will find it useful in their quest for viable social corporate responsibility and remediation plans in their respective host communities. The method proved to be a useful and objective tool for environmental planning.

关键词： Potentially Toxic Elements Environmental Pollution Assessment Health Risk Enrichment Factor Planning Crude Oil Exploration Utilization Core Niger Delta