Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro

作     者：Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson Olalekan Agboola Aline Augusti Boligon Margareth Linde Athayde 

作者机构：Biochemistry UnitDepartment of Biosciences and BiotechnologyKwara State UniversityMaleteP.M.B.1530IlorinNigeria Functional Foods and Nutraceuticals UnitDepartment of BiochemistryFederal University of TechnologyAkureNigeriaP.M.B.704Akure 340001Nigeria Department of Veterinary PhysiologyBiochemistry and PharmacologyUniversity of IbadanNigeria Phytochemical Research LaboratoryDepartment of Industrial PharmacyFederal University of Santa MariaBuilding 26Room 1115Santa Maria CEP 97105-900Brazil 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2016年第5卷第1期

页      面：17-23页

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

主　　题：peroxidation kidney inhibited 

摘      要：The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in ***(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric *** extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to *** extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent *** half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(Pkidney*** extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liverlungs*** fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids.