Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes

作     者：Olusola Olalekan Elekofehinti Oluwamodupe Cecilia Ejelonu Jean Paul Kamdem Oluwaseun Benedicta Akinlosotu Isaac Gbadura Adanlawo 

作者机构：Department of Biochemistry University of Ado-Ekiti Department of Biochemistry Adekunle Ajasin University Departamento de Ciências Biológicas Universidade Regional do Cariri-URCA Campus Pimenta Department of Biochemistry Federal University of TechnologyAkure 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2017年第8卷第7期

页      面：337-345页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Adipokines Adipose tissue Insulin resistance Antidiabetic Obesity 

摘      要：Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we sum-marized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.