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Tumor heterogeneity and therapy resistance-implications for future treatments of prostate cancer

journal of Cancer metastasis and Treatment 2017年第1期3卷 302-314页

作者： Fiona m.Frame Amanda R.Noble Sandra Klein Hannah F.Walker Rakesh Suman Richard Kasprowicz Vin m.mann matt S.Simms norman j.maitland Cancer Research Unit Department of BiologyUniversity of YorkHeslingtonNorth Yorkshire YO105DDUK Black Family Stem Cell Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Phase Focus Limited Electric WorksSheffield Digital CampusSheffield S12BJUK Department of Urology Castle Hill Hospital(Hull and East Yorkshire Hospitals NHS Trust)Cottingham HU165JQUK Hull York medical School University of HullHull HU67RXUK.

Aim:To develop new therapies for prostate cancer,disease heterogeneity must be *** includes patient variation,multi-focal disease,cellular heterogeneity,genomic changes and epigenetic *** requires more representative models to be used in more innovative ***:This study used a panel of cell lines and primary prostate epithelial cell cultures derived from patient *** assays were used;alamar blue,colony forming assays,γH2AX and Ki67 immunofluorescence and comet *** quantitative phase imaging(QPI),a label-free imaging technique,combined with Cell Analysis Toolbox software,was implemented to carry out real-time analysis of cells and to retrieve morphological,kinetic and population ***:A combination of radiation and Vorinostat may be more effective than radiation *** prostate cancer stem-like cells are more resistant to etoposide than more differentiated *** of QPI images showed that cell lines and primary cells differ in their size,motility and proliferation rate.A QPI signature was developed in order to identify two subpopulations of cells within a heterogeneous primary ***:Use of primary prostate epithelial cultures allows assessment of therapies whilst taking into account cellular *** of rare cell populations and embracing novel techniques may ultimately lead to identifying and overcoming treatment resistance.

关键词： Prostate ptychography live-cell imaging primary cells quantitative phase imaging

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An overview of marine & utility system for offshore platform

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Engineering Sciences 2013年第4期11卷 41-47页

作者： Ho jin jeong David norman Derrick Zhang DmAR Engineering Inc.

main marine 8, utility （m ＆ U） systems are essential to the routine operation of offshore units, and are extremely important as they are the system that will ensure the basic safety of offshore platforms. This paper gave a general explanation and guideline of the marine ＆ utility systems in offshore projects including their interface with topside, m ＆ U engineering, equipment sizing operation and control.

关键词： marine & utility systems offshore platform

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病态窦房结综合征

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广东医学 1982年第3期 48-49页

作者： norman W ,Desanctis m D

前言本文是美国麻省总医院Dr Desanctis教授于1981年11月11日在广东省心血管病研究所作学术报告的第二个讲题。病态窦房结综合征(病窦综合征),是在起搏器发展后才使人们感到兴趣,因为安装起搏器后对这种病疗效较好。窦房结的解剖位置是... 详细信息

前言本文是美国麻省总医院Dr Desanctis教授于1981年11月11日在广东省心血管病研究所作学术报告的第二个讲题。病态窦房结综合征(病窦综合征),是在起搏器发展后才使人们感到兴趣,因为安装起搏器后对这种病疗效较好。窦房结的解剖位置是在右房上部和上腔静脉交界处,长1～2 cm,宽4～5 mm。窦房结在组织切片中可着到两种细胞:一种是起搏细胞,另一种是其他的细胞。窦房结很靠近左心包膜,在心包膜外有很丰富的交感神经和迷走神经纤维,这些神经可以影响到窦房结的功能。窦房结血流供应较好,保证了它

关键词：病窦综合征血流供应心律失常窦房结心脏传导系统心动过速心搏过速起搏器心房起搏

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Vascular trauma： selected historical reflections from the western world

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Chinese journal of Traumatology 2011年第2期14卷 67-73页

作者： norman m. Rich Patricia L. mcKay David R. Welling Todd E. Rasmussen norman m. Rich Department of Surgery F. Edward Hebert School of Medicine Uniformed Services University of the Health Sciences Bethesda MD 20814 USA norman m. Rich Department of Surgery Hand and Upper Extremity Surgery Uniformed Services University of the Health Sciences Bethesda MD 20814 USA Division of General Surgery Norman M. Rich Department of Surgery Uniformed Services University Bethesda MD 20814 USA US Army Institute of Surgical Research Fort Sam Houston Texas 78230 USA

In the spirit of international exchanges of knowledge with colleagues from all over the world, who are interested in the care and treatment of vascular trauma, we offer selected historical reflections from the western world on vascular trauma. Whereas there are a number of key individuals and a variety of events that are important to us in our writing, we know essentially nothing about what is written by other cultures and, particularly, the Chinese. It is well recognized around the world that Chinese surgeons are among the first to be highly successful in re-plantation of severed extremities, repairing both injured arteries and veins. Also, we recognize that there are contributions in other parts of the world, which are not well known to us collectively. Contributions from the Arabic speaking part of the world come to mind because there is periodic brief reference. We offer our perspective hoping that there will be one or more Chinese surgeons who will offer us the benefit of sharing their perspective on important historical contribu- tions to the managing of vascular trauma outside of the western world, and, particularly, the English speaking literature. Once again, we encourage our colleagues in the Arabic speaking world to provide us with their perspective of the development and management of vascular trauma.

关键词： Vascular system injuries History Western world International educational exchange

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贵州锦丰(烂泥沟)超大型金矿床构造解析及构造成矿作用

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矿床地质 2007年第4期26卷 380-396页

作者：陈懋弘毛景文 Phillip j.Uttley Tony norman 吴六灵郑建民秦运忠中国地质科学院矿产资源研究所北京100037 Sino Gold mining Limited 中国地质大学北京100083 广西地勘局271地质队广西临桂541100

在矿区大比例尺填图的基础上,运用构造解析的理论和方法,对贵州锦丰(烂泥沟)金矿的构造特征、构造演化和构造控矿作用进行了系统的阐述。矿区构造线主要分为近NS向、NW向和NE向3组,其中NW向构造线控制了矿区的构造格架。构造变形主要经... 详细信息

在矿区大比例尺填图的基础上,运用构造解析的理论和方法,对贵州锦丰(烂泥沟)金矿的构造特征、构造演化和构造控矿作用进行了系统的阐述。矿区构造线主要分为近NS向、NW向和NE向3组,其中NW向构造线控制了矿区的构造格架。构造变形主要经历了同生期裂陷、造山期挤压、后碰撞造山侧向挤压和岩石圈伸展等4个阶段。盆地裂陷期间(D2-T2)形成的同生断层为后续的构造活动提供了最初的构造薄弱面,并成为主要的热液通道;造山期挤压期间(T3)形成了矿区最为明显的近NS向和NW向大型倒转褶皱和逆冲断层以及配套的NE向右旋走滑断层;后碰撞造山侧向挤压期间(j1)形成走向NE的叠加褶皱,并在F2-F3"X"型断裂系上形成近EW向的拉张区,矿质沿着拉张的空间沉淀就位;燕山期(j2-K)岩石圈伸展,形成小规模的近水平逆断层。上述4个主要构造变形阶段与右江盆地的裂陷-闭合-坍塌的发展演化历史相吻合,成矿发生在由挤压向拉张过渡的构造体制转换阶段。造山期逆冲作用形成的构造闭圈和后碰撞造山期间挤压向伸展转变的过程中形成的局部张性构造环境是矿质得以大量聚集、沉淀的主要构造控制因素。构造成矿作用是锦丰(烂泥沟)金矿单一矿体垂向延深1000m以上的主要制约因素。构造成矿的观点将为在滇黔桂"金三角"卡林型金矿带的深部找矿提供重要的理论依据。

关键词：地质学后碰撞造山构造成矿卡林型金矿锦丰(烂泥沟)金矿贵州

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Raman Scattering Study of PbSe Grown on(111)BaF_(2) Substrate

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Chinese Physics Letters 2000年第8期17卷 606-608页

作者： YANG Ai-ling WU Hui-Zhen LI Zhi-Feng QIU Dong-jiang CHANG Yong LI jian-Feng P.j.mcCann X.m.Fang Department of Information Science and Electronic Engineering Department of Physics Zhejiang UniversityHangzhou 310028 Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083 The University of Oklahoma NormanOklahoma73019-23USA

PbSe films were grown on(111)-oriented BaF_(2)substrates by using molecular beam *** resolution x-ray diffraction characterization showed good crystalline quality of PbSe *** longitudinal optical phonon at 135cm^(-1)and transverse optical phonon at 47.6cm-1 were observed by Raman scattering *** Raman tensor calculation demonstrates that both transverse-optical and longitudinal-optical(LO)phonons in PbSe crystal are Raman active on(111)-oriented surface,Furthermore,2LO phonon at about 270cm^(-1)and polaron at about 800cm^(-1)in PbSe,were also *** observed Raman frequencies are in good agreement with theoretical calculations using point ion model.

关键词： scattering transverse phonon

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变结构控制系统的计算机辅助设计

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机器人 1986年第2期 12-16页

作者： norman E.GOUGH ,ZIYAD m.ISmAIL ,黄章树

本文叙述一种关于工作在滑动模式下的变结构单变量控制系统的设计和仿真的计算机方法。对于给定的一个以状态变量形式表示的线性系统,本文提出了一些算法。这些算法可用于寻求在变结构状态反馈规律上的条件。这些条件将保证:有一个滑动... 详细信息

本文叙述一种关于工作在滑动模式下的变结构单变量控制系统的设计和仿真的计算机方法。对于给定的一个以状态变量形式表示的线性系统,本文提出了一些算法。这些算法可用于寻求在变结构状态反馈规律上的条件。这些条件将保证:有一个滑动超平面存在、从状态空间的任何地方均可命中这个平面并保证运动的稳定性。由于不需要系统以友形式来表示,并且给出了基于有限个状态量测的修正条件,因此这些算法是有独创性的。文中给出的计算机辅助设计程序包是采用了一系列可链接的 BASIC 程序段来实现这些算法。这里还给出了程序的流程图。在控制器设计之后,接着就可以对这种变结构控制系统进行仿真并绘出其相位和时间响应曲线。这里包括一些典型的变结构控制系统的结果并讨论了这种控制方式的实际好处。

关键词：状态变量程序包计算机辅助设计计算机辅助技术变结构控制系统超平面状态空间滑动模式

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BEARS:Radioactive Ion Beams Experiment at Berkeley

BEARS:Radioactive Ion Beams Experiment at Berkeley

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CCAST“放射性束物理”研讨会

作者： X.j.Xu. j Powell R.josten C.A Donahue R.F.Fairchild F.Q.Guo P.E jaustein R,m.Larimer C,m Lyneis P.mcnahan D.m moltz E,B norman j P ONeil m.W.Rowe H.F.Vanbrocklin D.Wutte Z.Q.Xie j,Cemy Lawrence Berkeley National Laborqtory USA Institute of modem Physics Chinese Academy of Sciences Brooljanven National Laboratory USA

＜正＞BEARS, or Berkeley Experiments with Accelerated Radioactive Species, is aninitiative to develop a radioactive ion-beam capability at Lawrence Berkeley NationalLaboratory. The basic concept for BEANS involves the coupling of radioisotopeproduction at an existing medical cyclotron with post-acceleration by the 88”cyclotron. These accelerators are separated by distance of about 350 *** be transported between the two via a gas-jet capillary（Fig.1）

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and Security 2022年第3期1卷 28-42页

作者： Robert L.Vadas jr. Robert m.Hughes Yeon jae Bae min jeong Baek Orestes Carlos Bello Gonzáles marcos Callisto Débora ReisdeCarvalho Kai Chen maria T.Ferreira Pablo Fierro jon S.Harding Dana m.Infante C.j.Kleynhans Diego R.macedo Isabela martins norman mercado Silva Nabor moya Susan j.Nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key Laboratory of marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias marinas y Limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(mmIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of mmIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)mmI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and mmI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI mmI Fish macroinvertebrates Algae Streams Rivers Lakes Wetlands Biological monitoring

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Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis

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World journal of Gastroenterology 2017年第29期23卷 5412-5421页

作者： Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos maria Papp Institute of Internal medicine Department of Gastroenterology University of Debrecen Faculty of Medicine Department of Laboratory medicine University of Debrecen Faculty of Medicine Debrecen Inova Diagnostics Inc.San Diego 1^st Department of Pediatrics Semmelweis University 1^st Department of medicine University of Pecs Gastroenterology Department of medicine Borsod-Abauj Zemplen County Hospital 1^st Department of medicine Semmelweis University

To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis (PSC) patients. mETHODSSera of 67 PSC patients [median age (range): 32 (5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin (AAA IgA/IgG) and gliadin (AGA IgA/IgG)] and for serum level of intestinal fatty acid-binding protein (I-FABP) by ELISA. markers of lipopolysaccharide (LPS) exposure [LPS binding protein (LBP)] and various anti-microbial antibodies [anti-OmP Plus IgA and endotoxin core IgA antibody (EndoCAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99 (14-106) mo]. One hundred and fifty-three healthy subjects (HCONT) and 172 ulcerative colitis (UC) patients were the controls. RESULTSA total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA IgA, AAA IgG, AGA IgA and AGA IgG, respectively. Frequencies of AAA IgA and AAA IgG (P mpared to both of the HCONT and the UC groups. In survival analysis, AAA IgA-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15 (1.27-20.86), P = 0.022 or for the mayo risk score (HR = 4.24 (0.99-18.21), P = 0.052]. AAA IgA-positivity was significantly associated with higher frequency of anti-microbial antibodies (P mP Plus IgA) and higher level of the enterocyte damage marker (median I-FABPAAA IgA posvsneg: 365 vs 166 pg/mL, P = 0.011), but not with serum LBP level. CONCLUSIONPresence of IgA type AAA identified PSC patients with progressive disease. moreover, it is associated with enhanced mucosal immune response to various micr

关键词： Primary sclerosing cholangitis Gut barrier dysfunction Intestinal fatty acid-binding protein Anti-F-actin antibody Anti-gliadin antibody

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