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Chinese Journal of Cancer 2011年第2期30卷 144-148页

作者： Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay nor azhari mohd zam Puay Hoon Tan Min-Han Tan Department of Medical Oncology National Cancer Centre Singapore Singapore 169610 Republic of Singapore Department of Otolaryngology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Urology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Pathology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore.

Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.

关键词：风险分类肾细胞癌症预后鼻医院管理 CC标准治疗方案

Influence of contact pressure and sliding speed dependence on the tribological characteristics of an activated carbonepoxy composite derived from palm kernel under dry sliding conditions

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Friction 2019年第3期7卷 227-236页

作者： Dayang nor Fatin MAHMUD mohd Fadzli Bin ABDOLLAH nor Azmmi Bin MASRIPAN noreffendyTAMALDIN Hilmi AMIRUDDIN Faculty of Mechanical Engineering Universiti Teknikal Malaysia MelakaHang Tuah JayaDurian TunggalMelaka76100Malaysia Centre for Advanced Research on Energy Universiti Teknikal Malaysia MelakaHang Tuah JayaDurian TunggalMelaka76100Malaysia

The objective of this work is to investigate the influence of contact pressure and sliding speed on the coefficient of friction and wear of an activated carbon-epoxy composite derived from palm kernel under dry sliding conditions.A wear mode map approach was employed to identify the transitions from mild to severe wear of the *** dry sliding test was executed by utilizing a ball-on-disc tribometer at different contact pressures and sliding speeds with a constant sliding distance and operating *** results showed that,regardless of the sliding speed,the friction coefficient and wear rate of the composite increased drastically when a critical limit of contact pressure is *** for the sliding speed,both the friction coefficient and wear rate increased first and thereafter decreased at a higher speed of 500 rpm.A wear mode map is proposed to classify the boundary from mild to severe wear *** predominant wear failures identified include micro-crack,fine grooves,debonding,delamination,debris,broken carbon,and fracture.

关键词： activated carbon agriculture waste palm kernel friction and wear pressure and speed

Role of toll like-receptor 2 in inflammatory activity of macrophage infected with a recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 333-339页

作者： nor Munirah Zakaria Rapeah Suppian norazmi mohd nor nor Fazila Che Mat School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: To investigate the role of toll-like receptor 2(TLR2) in inflammatory activity of macrophage infected with the recombinant Mycobacterium bovis bacillus Calmette-Guerin(rBCG). Methods: Mouse macrophage cell line J774 A.1 was infected with Mycobacterium bovis bacillus Calmette-Guerin(BCG) and rBCG cultures for 48 h in the presence or absence of 10 μg/mL of TLR2 inhibitor. Untreated macrophages were used as a negative control while lipopolysaccharide-stimulated macrophages were used as a positive control. The ability of the macrophage to engulf the BCG and rBCG in the absence or presence of TLR2 inhibitor was assessed using a phagocytic assay, while the production of inflammatory cytokines and nitric oxide by the infected macrophages was evaluated using ELISA and Griess reagent method, while the expression of the inducible nitric oxide synthase was determined using Western blot analysis. Results: The results showed that blocking TLR2 function reduced the phagocytic activity, nitric oxide production and proinflammatory cytokine secretion such as TNF-α, IL-1β and IL-12 p40 as well as inducible nitric oxide synthase expression in the infected macrophages. These data showed the importance of TLR2 in the activation of macrophages following BCG and r BCG infections. Conclusions: Through exploring the immunological mechanism which underlies the protection conferred by the candidate vaccine, this study will improve our understanding of the vaccine candidate's mechanism to protect the host from malaria infection.

关键词： Macrophages Mycobacterium bovis bacillus Calmette-Guerin Plasmodium falciparum Proinflammatory cytokine Toll-like receptor 2

Recovery of bird communities following the construction of a large-scale hydroelectric dam

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Ecological Processes 2021年第1期10卷 408-417页

作者： Affan Nasruddin-Roshidi Mohammad Saiful Mansor nor Adibah Ismail Ehwan Ngadi mohd Izzat-Husna Shahril Mod Husin Farah Shafawati mohd-Taib Rahmah Illias Shukor Md nor Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Kolej GENIUS Insan Universiti Sains Islam MalaysiaBandar Baru Nilai71800 NilaiNegeri SembilanMalaysia TNB Research Sdn Bhd No.1Kawasan Institusi PenyelidikanJalan Ayer Itam43000 KajangSelangorMalaysia Department of Wildlife and National Parks(PERHILITAN) Km.10Jln Cheras56100 Kuala LumpurWilayah PersekutuanMalaysia.

Background:Habitat degradation is known to have a major impact on the composition of bird communities,yet how these communities recover following such disturbance is less *** study examined bird community changes from pre-logging to recovery over the course of habitat disturbance caused by the development of the Hulu Terengganu Hydroelectric Dam Project in Peninsular Malaysia,between 2007 and *** surveys were conducted using point count observations and mist netting in the dam area from the prelogging phase until the operation ***:It was observed that while bird species significantly declined after large-scale habitat clearance between the pre-logging and construction phases,they showed positive signs of recovery from the inundation to operation *** findings indicate that the bird community is still recovering,and the permanent loss of habitat required by most of the original species has not occurred,as evidenced by *** species composition differed across phases due to varying habitat *** turnover rate and immigration rate(recolonisation and newly recorded species)were higher between the construction and operation *** was also observed that insectivorous birds were more heavily affected than others by changes to the landscape,which highlights the versatility,survivability and tolerance of certain species to extreme disturbance and habitat ***:Although the operation phase showed an incremental change in bird species richness due to recolonisation and newly recorded species,this value remains far from that of the pre-logging *** predict that bird species recovery will continue to increase for some time before reaching a plateau among the newly created islands,reservoir and catchment area of the dam.

关键词： Dam construction Extinction Habitat recovery Recolonisation Turnover

Preparation and Properties of Poly(vinyl alcohol)/Chitosan Blend Bio-nanocomposites Reinforced by Cellulose Nanocrystals

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Chinese Journal of Polymer Science 2014年第12期32卷 1620-1627页

作者： Susan Azizi Mansor Bin Ahmad nor Azowa Ibrahim mohd Zobir Hussein Farideh Namvar Department of Chemistry Faculty of Science University Putra Malaysia Materials Synthesis and Characterization Laboratory Institute of Advanced Technology University Putra Malaysia Institute of Tropical Forestry and Forest Products Universiti Putra Malaysia Mashhad Branch Islamic Azad University

The aim of this paper is to report the effect of the addition of cellulose nanocrystals（CNCs） on the mechanical, thermal and barrier properties of poly（vinyl alcohol）/chitosan（PVA/Cs） bio-nanocomposites films prepared through the solvent casting process. The characterizations of PVA/Cs/CNCs films were carried out in terms of X-ray diffraction（XRD）, transmission electron microscopy（TEM）, scanning electron microscopy（SEM）, thermogravimetric analysis（TGA and DTG）, oxygen transmission rate（OTR）, and tensile tests. TEM and SEM results showed that at low loading levels, CNCs were dispersed homogenously in the PVA/Cs matrix. The tensile strength and modulus in films increased from 55.1 MPa to 98.4 MPa and from 395 MPa to 690 MPa respectively, when CNCs content went from 0 wt% to 1.0 wt%. The thermal stability and oxygen barrier properties of PVA/Cs matrix were best enhanced at 1.0 wt% of CNCs loading. The enhanced properties attained by incorporating CNCs can be beneficial in various applications.

关键词： Bio-nanocomposite Poly(vinyl alcohol)/chitosan Cellulose nanocrystals Mechanical properties Thermal properties.

A Preliminary Genetic Investigation of Rastrelliger Kanagurta Based on Random Amplified Polymorphic DNA and Mitochondrial ND2 Gene

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湿地科学 2008年第4期6卷 518-525页

作者： Siti Azizah mohd nor Abu Talib A mohd Ghows M A Samsudin B Aquaculture Research Group School of Biological Sciences University Sains Malaysia 11800 Minden Penang Malaysia Fisheries Research Institute 11900 Batu Maung Penang Malaysia

In a preliminary investigation, Random Amplified Polymorphic DNA (RAPD) analysis and partial mitochondrial ND2 gene sequencing were conducted to study the genetic variation of the Indian mackerel, Rastrelliger kanagurta along a 450 km stretch of its distribution on the west coast of Peninsular Malaysia. A total of 53 individuals from 6 populations were analyzed using 4 RAPD primers and a sub-sample of 15 individuals was chosen for sequencing of partial ND2 gene. Comparison between the 2 markers revealed genetic structuring in the RAPD results but genetic homogeneity for ND2 gene. Based on the former there may be at least 2 genetically differentiated groups of Rastrelliger kanagurta along this stretch.

关键词：基因 DNA分析分析方法生物技术水生生物

Multi-valued interval neutrosophic linguistic soft set theory and its application in knowledge management

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CAAI Transactions on Intelligence Technology 2020年第3期5卷 200-208页

作者： nor Liyana Amalini mohd Kamal Lazim Abdullah Ilyani Abdullah Muhammad Saqlain Faculty of Ocean Engineering and Informatics Universiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia Department of Mathematics Lahore Garrison UniversityDHA Phase VISector-CLahorePakistan

This study proposed the concepts of a multi-valued interval neutrosophic linguistic soft set(MVINLSS)by integrating the concepts of multi-valued interval neutrosophic soft set and linguistic *** is presented as it can deal with ambiguous and uncertain information in decision making which is characterised by linguistic *** proposed set amalgamates quantitative assessment with the qualitative assessment which can solve complex problems with ambiguity,uncertainty,and *** can be an effective tool to describe the real decision-makers’opinions and reflect their ***,the authors propose the basic operational rules of ***,they define a multi-valued interval neutrosophic linguistic soft weighted arithmetic averaging *** work proposed a multi-criteria decision-making(MCDM)method which considers different priority levels of criteria and the criteria values take the form of multi-valued interval neutrosophic linguistic soft ***,the proposed MCDM method is applied to the knowledge management case,considering 11 criteria.

关键词： valued qualitative integrating

Distribution of Chironomidae (Insecta: Diptera) in polluted rivers of the Juru River Basin, Penang, Malaysia

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Journal of Environmental Sciences 2010年第11期22卷 1718-1727页

作者： Salman A. Al-Shami Che Salmah Md Rawi Abu HassanAhmad Siti Azizah mohd nor School of Biological Sciences Universiti Sains Malaysia Centre for Marine and Coastal Studies Universiti Sains Malaysia

The influence of physical and chemical parameters on the abundance and diversity of chironomids was studied in six rivers with moderate to highly polluted water in the Juru River Basin. The rivers： Ceruk Tok Kun （CTKR） as reference site, and polluted rivers of Pasir （PR）, Juru （JR）, Permatang Rawa （PRR）, Ara （AR） and Kilang Ubi （KUR） were sampled over a period of five months （November 2007–March 2008）. Nine chirnomid species： Chironimus kiiensis, C. javanus, Polypedilum trigonus, Microchironomus sp., Dicrotendipes sp., Tanytarsus formosanus, Clinotanypus sp., Tanypus punctipennis and Fittkauimyia sp. were identified. Assessment of their relationships with several environmental parameters was performed using the canonical correspondence analysis （CCA）. Tanytarsus formosanus was the most dominant in the relatively clean CTKR and moderately polluted JR with mean densities of 19.66 and 25.32 m 2 , respectively while C. kiiensis was abundant in more polluted rivers. Tanytarsus formosanus, Dicrotendipes sp. and Microchironomus sp. were grouped under moderate to high water temperature, total organic matter （TOM）, total suspended solids （TSS）, velocity, pH, phosphates and sulphates. However, Tanypus punctipennis, Fittkauimyia sp., and Clinotanypus sp. were associated with high contents of river sediment such as TOM, Zn and Mn and water ammonium-N and nitrate-N and they were associated with higher dissolved oxygen （DO） content in the water. Chironomus kiiensis, C. javanus and P. trigonus showed positive relationships with TOM, ammonium-N and nitrate-N as well as trace metals of Zn, Cu and Mn. These three species could be considered as tolerant species since they have the ability to survive in extreme environmental conditions with low DO and high concentrations of pollutants. Based on the water parameter scores in all rivers, the highest diversity of chironomid larvae was reported in CTKR. With higher concentrations of organic and/or inorganic pollutants as reported in PPR, K

关键词： chironomid larvae Juru River physicochemical parameters canonical correspondence analysis

Development and characterization of food packaging bioplastic film from cocoa pod husk cellulose incorporated with sugarcane bagasse fibre

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Journal of Bioresources and Bioproducts 2020年第4期5卷 248-255页

作者： Siti Nuurul Hud Mohammad Azmin Najah Aliah binti mohd Hayat mohd Shukri Mat nor Faculty of Agro-Based Industry Universiti Malaysia Kelantan Jeli CampusLocked Bag 10017600 Jeli KelantanMalaysia Department of Research and Development Jeli Agricultural TechnologyPT7458 Kampung Gemang Baru17700 Ayer LanasJeli KelantanMalaysia

Agricultural wastes,including cocoa pod husk(waste from the chocolate industry)and sugarcane bagasse(waste from the sugar industry),are increasing day by *** development of food packaging biofilms from these two wastes could be beneficial to the environment and ***,this study was conducted to develop biodegradable plastic films by using cocoa pod husk and sugarcane *** and fibre were extracted from cocoa pod husk and sugar-cane bagasse,*** developed bioplastic films were divided into several concentration ratios of cellulose and fibre which are 100꞉0(100%cellulose),75꞉25(cellulose꞉fibre),50꞉50(cel-lulose꞉fibre),25꞉75(cellulose꞉fibre),and 0꞉100(100%fibre).The physicochemical properties for all bioplastic concentration ratios were determined in terms of sensory evaluation,drying time,moisture content,water absorption and water vapor *** the observation and anal-ysis of the physicochemical properties of bioplastic,we found that the most suitable bioplastic film for food packaging goes to the combination of 75%cellulose and 25%fibre bioplastic,as it demonstrated the lowest water absorption percentage and water vapor permeability.

关键词： Agricultural waste Cocoa pod husk Sugarcane bagasse Bioplastic film Water absorption Moisture content

Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review

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Journal of Animal Science and Biotechnology 2019年第4期10卷 851-872页

作者： Hidayat mohd Yusof Rosfarizan Mohamad Uswatun Hasanah Zaidan nor’Aini Abdul Rahman Department of Bioprocess Technology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Bioprocessing and Biomanufacturing Research Centre Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Biochemistry Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia

In recent years, zinc oxide nanoparticles(ZnO NPs) have gained tremendous attention attributed to their unique properties. Notably, evidence has shown that zinc is an important nutrient in living organisms. As such, both prokaryotes and eukaryotes including bacteria, fungi and yeast are exploited for the synthesis of ZnO NPs by using microbial cells or enzyme, protein and other biomolecules compounds in either an intracellular or extracellular route. ZnO NPs exhibit antimicrobial properties, however, the properties of nanoparticles(NPs) are depended upon on their size and shape, which make them specific for various applications. Nevertheless, the desired size and shape of NPs can be obtained through the optimization process of microbes mediated synthesis by manipulating their reaction conditions. It should be noted that ZnO NPs are synthesized by various chemical and physical ***, these methods are expensive and not environmentally friendly. On that account, the microbes mediated synthesis of ZnO NPs have rapidly evolved recently where the microbes are cleaner, eco-friendly, nontoxic and biocompatible as the alternatives to chemical and physical practices. Moreover, zinc in the form of NPs is more effective than their bulk counterparts and thus, they have been explored for many potential applications including in animals industry. Notably, with the advent of multi-drug resistant strains, ZnO NPs have emerged as the potential antimicrobial agents. This is mainly due to their superior properties in combating a broad spectrum of pathogens. Moreover, zinc is known as an essential trace element for most of the biological function in the animal’s body. As such, the applications of ZnO NPs have been reported to significantly enhance the health and production of the farm animals. Thus, this paper reviews the biological synthesis of ZnO NPs by the microbes, the mechanisms of the biological synthesis, parameters for the optimization process and their potential

关键词： Animals Antimicrobial Feed supplement Microbial synthesis Nanotechnology Zinc oxide nanoparticles