Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review

作     者：Hidayat Mohd Yusof Rosfarizan Mohamad Uswatun Hasanah Zaidan Nor’Aini Abdul Rahman 

作者机构：Department of Bioprocess TechnologyFaculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Bioprocessing and Biomanufacturing Research CentreFaculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of BiochemistryFaculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2019年第10卷第4期

页      面：851-872页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0832[工学-食品科学与工程（可授工学、农学学位）] 090502[农学-动物营养与饲料科学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：Universiti Putra Malaysia(UPM)for financing this work through Putra Graduate Initiative(IPS) 

主　　题：Animals Antimicrobial Feed supplement Microbial synthesis Nanotechnology Zinc oxide nanoparticles 

摘      要：In recent years, zinc oxide nanoparticles(ZnO NPs) have gained tremendous attention attributed to their unique properties. Notably, evidence has shown that zinc is an important nutrient in living organisms. As such, both prokaryotes and eukaryotes including bacteria, fungi and yeast are exploited for the synthesis of ZnO NPs by using microbial cells or enzyme, protein and other biomolecules compounds in either an intracellular or extracellular route. ZnO NPs exhibit antimicrobial properties, however, the properties of nanoparticles(NPs) are depended upon on their size and shape, which make them specific for various applications. Nevertheless, the desired size and shape of NPs can be obtained through the optimization process of microbes mediated synthesis by manipulating their reaction conditions. It should be noted that ZnO NPs are synthesized by various chemical and physical ***, these methods are expensive and not environmentally friendly. On that account, the microbes mediated synthesis of ZnO NPs have rapidly evolved recently where the microbes are cleaner, eco-friendly, nontoxic and biocompatible as the alternatives to chemical and physical practices. Moreover, zinc in the form of NPs is more effective than their bulk counterparts and thus, they have been explored for many potential applications including in animals industry. Notably, with the advent of multi-drug resistant strains, ZnO NPs have emerged as the potential antimicrobial agents. This is mainly due to their superior properties in combating a broad spectrum of pathogens. Moreover, zinc is known as an essential trace element for most of the biological function in the animal’s body. As such, the applications of ZnO NPs have been reported to significantly enhance the health and production of the farm animals. Thus, this paper reviews the biological synthesis of ZnO NPs by the microbes, the mechanisms of the biological synthesis, parameters for the optimization process and their potential