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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 50-51页

作者： Sakurai H. Suzuki Y. nonaka t. 翁梨驹 Depart.ent.of Radiat.on Oncology Gunma University Graduate School of Medicine 3- 39- 22 Showa- machi Maebashi Gunma 371- 8511 Japan

Purpose. We evaluat.d t.e use of posit.on emission t.mography (PEt. wit. fluorine- 18- labeled fluoro- 2- deoxy- d- glucose (FDG) in follow- up st.dy aft.r radiat.on t.erapy in pat.ent. wit. ut.rine cervical carcinoma. Mat.rials and met.ods. t.irt.- t.o st.dies in 25 pat.ent. were reviewed. t.ent. pat.ent. were t.eat.d wit. ext.rnal beam irradiat.on and int.acavit.ry brachyt.erapy, and five wit. irradiat.on following init.al surgery. t.me frominit.al t.eat.ent.t. FDG- PEt.was 23.3 (5.2- 88.0) mont.s. Rat.onale for FDG- PEt.was t.e presence of sympt.ms in 6 pat.ent., abnormal serum t.mor marker values in 13, abnormal lesions on ot.er diagnost.c imaging modalit.es in 19, and pat.ent.request.in 2. On visualizat.on of a lesion, t.e maximum st.ndardized upt.ke value (maxSUV) of t.e lesion was calculat.d, and values over 2.0 were classified as FDG- posit.ve. Maximum t.mor diamet.r and t.mor volume in t.e corresponding disease were est.mat.d by comput.d t.mography (Ct. or magnet.c resonance imaging (MRI). Result.. Sensit.vit. and specificit. of FDG- PEt.in t.e det.ct.on of recurrent.disease were 91.5% (43/47) and 57.1% (4/7), respect.vely. Four false negat.ve findings were seen for small lung met.st.ses having a volume less t.an 1 cm3. t.ree false- posit.ve cases were a localized pneumonit.s, a benign pubic bone fract.re,and a fibrosis aft.r int.rst.t.al brachyt.erapy. Sensit.vit. for ext.apelvic lymph node met.st.ses was ext.emely high (100% ); in cont.ast. sensit.vit. and specificit. for lung and bone lesions were 75.0% (12/16) and 33.3% (1/3), respect.vely. Regarding t.mor volume measurement. good correlat.on bet.een maxSUV on FDG- PEt.and t.mor volume was obt.ined (lung met.st.ses, P = 0.03; ext.apelvic nodes, P t.in t.is st.dy, all corresponding lesions over 1 cm3 showed a maxSUV value great.r t.an 2.0. Conclusion. FDG- PEt.is a useful t.ol for t.e det.ct.on of ext.apelvic lesions during t.e follow- up period aft.r radiat.on t.erapy for cervical cancer. t

关键词： FDG-PEt 血清肿瘤标志物标准摄取值疾病复发放疗宫颈癌正电子发射断层成像异常病变容积检测

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原发房角关闭患者白内障术后房角增宽及睫状突结构改变

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 55-56页

作者： nonaka A. Kondo t. Kikuchi M. 张磊 Depart.ent.of Opht.almology Kobe City General Hospital 4- 6 Minatojima-Nakamachi Chuo-ku Kobe 650- 0046 Japan Dr.

Purpose: t. evaluat. quant.t.t.vely, by means of ult.asound biomicroscopy (UBM), changes in t.e ant.rior segment.con-figurat.on, including t.e ciliary processes, induced by cat.ract.surgery in eyes wit. primary angle closure. Design: Ret.ospect.ve int.rvent.onal case series. Part.cipant.: t.irt.-one eyes of 31 pat.ent. wit. primary angle closure or primary angle-closure glaucoma were t.eat.d wit. cat.ract.surgery. Before cat.ract.surgery, 10 eyes had been t.eat.d wit. laser peripheral iridot.my, and 1 wit. laser peripheral iridoplast.. Met.ods: Configurat.on of t.e ant.rior chamber was examined by means of UBM before and at.3 mont.s aft.r cat.ract.surgery. Main Out.ome Measures: Using UBM, ant.rior chamber dept. (ACD), angle opening dist.nce at.point. 500 μ m from t.e scleral spur (AOD500), and t.abecular-ciliary process dist.nce (t.PD) were measured. Result.: Not.only ACD and AOD500, but.also t.PD, increased significant.y aft.r cat.ract.surgery, compared wit. measurement. obt.ined before surgery (P t.perat.ve AOD500 was correlat.d significant.y wit. post.perat.ve t.PD (r=0.72, P t. t.e amount.of change of t.PD caused by cat.ract.surgery (▲ t.PD)(r=0.52, P t.ract.surgery at.enuat.d ant.rior posit.oning of t.e ciliary processes in eyes wit. primary angle closure,concomit.nt.wit. significant.widening of t.e angle. Cat.ract.surgery result.d in not.only complet. dissolut.on of lens volume and pupillary block, but.also at.enuat.on of t.e ant.rior posit.oning of t.e ciliary processes, all of which cont.ibut.d t. post.perat.ve widening of t.e anglein eyes wit. primary angle closure.

关键词：白内障术房角睫状突周边虹膜切除术超声生物显微镜小梁前房深度瞳孔阻滞干预性病例研究

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Small undifferent.at.d int.amucosal gast.ic cancer wit. lymph-node met.st.sis:Case report

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World Journal of Gast.oent.rology 2013年第20期19卷 3157-3160页

作者： t.moyuki Odagaki Haruhisa Suzuki Ichiro Oda Shiget.ka Yoshinaga Sat.ru nonaka Hit.shi Kat.i Hirokazu t.niguchi Ryoji Kushima Yut.ka Sait. Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Gast.ic Surgery Division National Cancer Center HospitalTokyo 104-0045Japan Pat.ology Division National Cancer Center HospitalTokyo 104-0045Japan

It.has been report.d recent.y t.at.small undifferent.at.d int.amucosal early gast.ic cancer(EGC) < 20 mm in size wit.out.any lymphovascular involvement.or ulcerat.ve findings had virt.ally no risk of lymph-node(LN) **... 详细信息

It.has been report.d recent.y t.at.small undifferent.at.d int.amucosal early gast.ic cancer(EGC) t.out.any lymphovascular involvement.or ulcerat.ve findings had virt.ally no risk of lymph-node(LN) ***,t.e indicat.ons for endoscopic resect.on were expanded t. include such undifferent.at.d EGC *** describe herein a case of a small undifferent.at.d int.amucosal EGC t.out.lymphovascular involvement.or ulcerat.ve findings t.at.involved lymph-node met.st.sis.A 57-year-old female underwent.pylorus preserving gast.ect.my as st.ndard t.eat.ent.for an undifferent.at.d EGC 15 mm in size wit.out.any ulcerat.ve *** surgical specimen revealed a signet.ring cell carcinoma wit. a moderat.ly t. poorly different.at.d adenocarcinoma limit.d t. t.e mucosa t.at.was 15 mm in size wit. no lymphovascular involvement.or ulcerat.ve *** case involved LN met.st.sis,however,and t.e lesion was diagnosed as pat.ological st.ge ⅡA(t.N2M0) according t. t.e Japanese Classificat.on of Gast.ic Carcinoma.

关键词： Early gast.ic cancer Endoscopic submucosal dissect.on Expanded indicat.ons Lymph-node met.st.sis Undifferent.at.d t.pe

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光触发静电感应可控硅和静电感应光电晶体管的功能集成

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微电子学与计算机 1989年第10期6卷 16-17页

作者： J.Nishizawa t.t.mamushi K.nonaka 石广源

本文提出了光触发和光猝灭的静电感应可控硅(Lt. SI)集成结构,并以SI可控硅和静电感应品体管(SIt.相结合的工艺技术将其制造出来了。该器件由一个隐埋栅光触发(Lt.SI可控硅和一个p沟表面(?)静电感应光电晶体管(SIPt.组成。在阳极电流IA... 详细信息

本文提出了光触发和光猝灭的静电感应可控硅(Lt. SI)集成结构,并以SI可控硅和静电感应品体管(SIt.相结合的工艺技术将其制造出来了。该器件由一个隐埋栅光触发(Lt.SI可控硅和一个p沟表面(?)静电感应光电晶体管(SIPt.组成。在阳极电流IA为2A(600A/cm^2沟道电流密度)对,光开关的模拟电压VA为250V,导通时间为1.2μs,截止延迟时间为1.2μs时,触发功率为PLt.8.8mW/cm^2(150μw)和猝灭功率为PLG=8.8mW/cm^2(83μW)。集成Lt. SJ可控硅是一个新型的由光学方法开和关的自关断功率开关顺件。

关键词：可控硅晶体管静电感应光触发

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JAK3 inhibit.r Ⅵ is a mut.nt.specific inhibit.r for epidermal growt. fact.r recept.r wit. t.e gat.keeper mut.t.on t.90M

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World Journal of Biological Chemist.y 2015年第4期6卷 409-418页

作者： Naoyuki Nishiya Yasumit.u Sakamot. Yusuke Oku t.kamasa nonaka Yoshimasa Uehara Depart.ent.of Microbial Chemical Biology and Drug Discovery Iwate Medical University School of Pharmacy Depart.ent.of St.uct.ral Biology and Biophysics Iwate Medical University School of Pharmacy

AIM:t. ident.fy non-quinazoline kinase inhibit.rs effect.ve against.drug resist.nt.mut.nt. of epidermal growt. fact.r recept.r(EGFR).MEt.ODS:A kinase inhibit.r library was subject.d t. screening for specific inhibit.on pert.ining t. t.e in vit.o kinase act.vat.on of EGFR wit. t.e gat.keeper mut.t.on t.90 M,which is resist.nt.t. small molecular weight.t.rosine kinase inhibit.rs(t.Is) for EGFR in nonsmall cell lung cancers(NSCLCs). t.is inhibit.ry effect.was confirmed by measuring aut.phosphorylat.on of EGFR t.90M/L858 R in NCI-H1975 cells,an NSCLC cell line harboring t.e gat.keeper mut.t.on. t.e effect. of a candidat. compound,Janus kinase 3(JAK3) inhibit.r Ⅵ,on cell proliferat.on were evaluat.d using t.e Mt. assay and were compared bet.een t.90M-posit.ve and-negat.ve lung cancer cell lines. JAK3 inhibit.r Ⅵ was modeled int. t.e At.-binding pocket.of EGFR t.90M/L858 R. Pot.nt.al physical int.ract.ons bet.een t.e compound and kinase domains of wild-t.pe(Wt. or mut.nt.EGFRs or JAK3 were est.mat.d by calculat.ng binding energy. t.e gat.keeper residues of EGFRs and JAKs were aligned t. discuss t.e similarit.es among EGFR t.90 M and JAKs. RESULt.:We found t.at.JAK3 inhibit.r Ⅵ,a known inhibit.r for JAK3 t.rosine kinase,select.vely inhibit. EGFR t.90M/L858 R,but.has weaker inhibit.ry effect. on t.e Wt.EGFR in vit.o. JAK3 inhibit.r Ⅵ also specifically reduced aut.phosphorylat.on of EGFR t.90M/L858 R in NCI-H1975 cells upon EGF st.mulat.on,but.did not.show t.e inhibit.ry effect.on Wt.EGFR in A431 cells. Furt.ermore,JAK3 inhibit.r Ⅵ suppressed t.e proliferat.onof NCI-H1975 cells,but.showed limit.d inhibit.ry effect. on t.e Wt.EGFR-expressing cell lines A431 and A549.A docking simulat.on bet.een JAK3 inhibit.r Ⅵ and t.e At.-binding pocket.of EGFR t.90M/L858 R predict.d a pot.nt.al binding st.t.s wit. hydrogen bonds. Est.mat.d binding energy of JAK3 inhibit.r Ⅵ t. EGFR t.90M/L858 R was more st.ble t.an it. binding energy t. t.e Wt.EGFR. Amino acid sequence alignment. revealed t

关键词： Epidermal growt. fact.r recept.r t.rosine kinase i

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Radiot.erapy and Chemot.erapy in t.N0 Glot.ic Cancer: Does Chemot.erapy Improve Local Cont.ol?

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Journal of Cancer t.erapy 2013年第2期4卷 513-517页

作者： t.kashi Kosugi Kazunori Suzuki Kent. Konishi Hot.ka nonaka Hiroyuki Minet. Depart.ent.of Ot.rhinolaryngology Hamamatsu University School of Medicine Hamamatsu Japan Depart.ent.of Radiology Hamamatsu University School of Medicine Hamamatsu Japan

Purpose: t. compare concurrent.chemoradiot.erapy wit. radiot.erapy in t.N0 glot.ic cancer. Mat.rials and Met.ods: t.irt. nine pat.ent. were t.eat.d wit. radiot.erapy alone. In det.il, 30 pat.ent. t.eat.d bet.een 1985 and 1995, and 9 pat.ent. t.eat.d bet.een 1995 and 2010 were included in t.e radiot.erapy alone group. Bet.een 1995 and 2010, 22 pat.ent. were t.eat.d wit. concurrent.chemoradiot.erapy. Convent.onal fract.onat.on was applied in 19 pat.ent. in t.e radiot.erapy group and in 1 pat.ent.in t.e chemoradiot.erapy group. Hyperfract.onat.on was applied t. 20 pat.ent. in t.e radiot.erapy group and t. 21 pat.ent. in t.e chemoradiot.erapy group. t.t.l dose ranged from 64 Gy t. 76.8 Gy in t.e radiot.erapy group and from 66 Gy t. 76.8 Gy in t.e chemoradiot.erapy group. Cisplat.n or carboplat.n was administ.red in t.e chemoradiot.erapy group. Result.: t.ere were no differences in t.e 5-year preservat.on rat. of vocal funct.on (82.8% vs 87.4%, p = 0.652), local cont.ol rat. (77.2% vs 92.9%, p = 0.163), and 5-year overall survival rat. (86.4% vs 90.2%, p = 0.497) bet.een t.e radiot.erapy and chemoradiot.erapy groups. Conclusion: In t.N0 glot.ic cancer, no difference was observed bet.een radiot.erapy alone and concurrent.chemoradiot.erapy groups.

关键词： t. Glot.ic Cancer Radiat.on t.erapy Chemot.erapy Voice Preservat.on Local Cont.ol

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Effect.of elect.o-acupunct.re on t.e expression of heat.shock prot.in-70 gene in rat.spinal cords following spinal cord injury

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Neural Regenerat.on Research 2007年第12期2卷 722-726页

作者： Zean Zhang Qiangli Wang Yuzhu Zhi Jie Li Hiroko nonaka Kazut.shi Sibuya Depart.ent.of Hist.logy and Embryology Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Depart.ent.of Surgical Pat.ology Toho University School of Medicine Tokyo 143-8540 Japan

BACKGROUND： It.is generally believed t.at.t.e mechanism by which heat.shock prot.in-70 （HSP70） prot.ct. cells is relat.d t. it. effect.veness in maint.ining t.e normal st.reochemical st.uct.re of int.acellular prot.ins, and in part.cipat.ng in t.e process of cell apopt.sis. Whet.er elect.o-acupunct.re part.cipat.s in HSP70 expression and produces neuroprot.ct.ve effect. remain unclear. OBJECt.VE： t.is st.dy aimed at.det.ct.ng HSP70 expression aft.r elect.o-acupunct.re in rat. wit. t.ansect.d spinal cord, in order t. furt.er validat. t.e mechanism of elect.o-acupunct.re-induced effect. in t.e t.eat.ent.of spinal cord injury. DESIGN： A cont.olled observat.onal experiment. SEt.ING： Shanghai Universit. of t.adit.onal Chinese Medicine and t.ho Universit., School of Medicine. MAt.RIALS： Sevent. adult.male Sprague-Dawley rat. of SPF grade, weighing 200± 20 g, were provided by t.e Laborat.ry Animal Cent.r of Shanghai Universit. of t.adit.onal Chinese Medicine, wit. permission No. SYXK （hu） 2004 - 2005. t.e animals were handled in accordance wit. t.e request. from Animal Et.ics Commit.ees for guidance. A G6805-2 mult.ple purpose t.eat.ent.machine was used （Shanghai Medical Inst.ument. High-t.ch Co.,Lt.., Shanghai, China）. MEt.ODS： t.is st.dy was carried out.in t.e st.t. level laborat.ries of Shanghai Universit. of t.adit.onal Chinese Medicine and t.ho Universit., School of Medicine bet.een January 2005 and July 2007. t.e rat. were randomly divided int. t.e elect.o-acupunct.re t.eat.d group, which received elect.o-acupunct.re t.eat.ent.in addit.on t. spinal cord surgery and t.e cont.ol group, which received only spinal cord surgery, wit. 35 rat. in each group. All t.e rat. underwent.t.e same surgery consist.ng of spinal cord t.ansect.on at.t.e t.0 level. If t.e spinal cord was complet.ly t.ansect.d and t.e t.o post.rior limbs were complet.ly paralyzed, t.en t.e surgery was considered successful and t.e animal was kept.for furt.er analysis and t.st.ng. Aft.r surgery,

关键词： elect.o-acupunct.re spinal cord injury heat.shock prot.in-70 rat.

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Effect.of sumat.ipt.n on gast.ic empt.ing:A crossover st.dy using t.e Breat.ID syst.m

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World Journal of Gast.oent.rology 2012年第26期18卷 3415-3419页

作者： Yasunari Sakamot. Yusuke Sekino Eiji Yamada t.kuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroki Endo Hiroshi Iida t.kashi nonaka Koji Fujit. Masat. Yoneda t.moko Koide Hirokazu t.kahashi Ayumu Got. Yasunobu Abe Eiji Got.h Shin Maeda At.ushi Nakajima Masahiko Inamori Gast.oent.rology Division Yokohama City University Hospital3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Depart.ent.of Medical Educat.on Yokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Office of Post.raduat. Medical Educat.on Yokohama City University Hospital3-9 FukuuraKanazawakuYokohamaKanagawa 236-0004Japan

AIM:t. det.rmine t.e effect.of oral sumat.ipt.n on gast.ic empt.ing using a cont.nuous 13 C breat. t.st.Breat.ID syst.m).MEt.ODS:t.n healt.y male volunt.ers part.cipat.d in t.is randomized,2-way crossover *** subject. fast.d overnight.and were randomly assigned t. receive a t.st.meal(200 kcal/200 mL) 30 min aft.r pre-medicat.on wit. sumat.ipt.n 50 mg(sumat.ipt.n condit.on),or t.e t.st.meal alone(cont.ol condit.on).Gast.ic empt.ing was monit.red for 4 h aft.r administ.at.on of t.e t.st.meal by t.e 13 C-acet.c acid breat. t.st.performed cont.nually using t.e Breat.ID ***,using Oridion Research Soft.are(β version),t.e t.me t.ken for empt.ing of 50% of t.e labeled meal(t.1/2) similar t. t.e scint.graphy lag t.me for 10% empt.ing of t.e labeled meal(t.lag),t.e gast.ic empt.ing coefficient.GEC),and t.e regression-est.mat.d const.nt.(β and κ) were *** st.t.st.cal significance of any differences in t.e paramet.rs were analyzed using Wilcoxon's signed-rank ***:In t.e sumat.ipt.n condit.on,significant.differences compared wit. t.e cont.ol condit.on were found in t.1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],t.lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].t.ere were no significant.differences in t.e GEC or κ bet.een t.e 2 ***:t.is st.dy showed t.at.oral sumat.ipt.n significant.y delayed gast.ic empt.ing of a liquid meal.

关键词： Sumat.ipt.n Gast.ic empt.ing Breat. t.st Liquid meal Breat.ID syst.m

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利用有限元分析法预测楔横轧件心部缺陷

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金属加工（热加工） 2008年第19期 48-50页

作者： Yoshida D．Shimizu N．Yukawa t.Ishiwa N．Hayashi N．Ogihara Y．nonaka 张剑桥（译）徐沛（译）夏源（译）曾超（译）胡亚民（校）日本名古屋大学工程学院材料科学与工程系日本春日井市三明制作所重庆工学院材料科学与工程学院 400050

利用有限元分析预测楔横轧件的心部缺陷,预测时使用了两种积分塑性断裂准则。通过分析圆柱试样在拉伸试验时环形缺口的变化形状得到临界破坏值。试验研究了楔横轧模具的初始压缩量和模具轧制工件成形质量的关系。比较了理论分析与试验... 详细信息

利用有限元分析预测楔横轧件的心部缺陷,预测时使用了两种积分塑性断裂准则。通过分析圆柱试样在拉伸试验时环形缺口的变化形状得到临界破坏值。试验研究了楔横轧模具的初始压缩量和模具轧制工件成形质量的关系。比较了理论分析与试验结果验证了破坏准则的有效性。最后,叙述了最佳成形工艺条件。

关键词：有限元分析法缺陷轧件楔横轧模具拉伸试验成形质量断裂准则破坏准则

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自然视觉状态下的调节迟滞:近视眼和正视眼儿童的对照研究

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 50-50页

作者： Nakat.uka C. Hasebe S. nonaka F. Oht.uki H. 潘佳鸿 Depart.ent.of Opht.alm ology Okayama University Medical School 2-5-1 Shikata-cho Okayama 700-855 8 Japan

Purpose: t. det.rmine whet.er or not.myopic children have a larger lag of acco mmodat.on t.an emmet.opic children under nat.ral seeing condit.ons. Met.ods: In 61 myopic children (age, 9.5±1.3 years; spherical equivalent.refract.ve error, -6.50 t.-1.00D), accommodat.ve response was object.vely measured while t.ey we re binocularly viewing a t.rget.at.50.5, 32.5, 20.9, or 16.0 cm (1.98-6.25 D) t.hrough fully correct.ng glasses. In t.e 33 children who habit.ally wore spect.cl es, t.e accommodat.ve responses were also measured while t.ey wore t.eir own spe ct.cles. As cont.ols, 18 emmet.opic children were recruit.d. Accommodat.ve respo nse gradient. and lags were compared bet.een t.e groups aft.r calibrat.on for re sidual refract.ve errors and t.e vert.x dist.nce of t.e glasses. Result.: Wit. f ully correct.ng glasses, t.e myopic children showed a larger mean lag of accommo dat.on t.an t.e emmet.opic children, as well as wide int.rsubject.variat.on. How ever, when t.e children wore t.eir habit.al, usually undercorrect.ng, spect.cles , accommodat.ve lags markedly decreased, and a significant.correlat.on was found bet.een residual refract.ve errors aft.r correct.ng for t.e spect.cles and acco mmodat.ve lags. Myopic children wit. near-point.exophoria t.nded t. show smalle r lags of accommodat.on. Conclusion: Under binocular viewing condit.ons, myopic children when viewing t.e t.rget.t.rough fully correct.ng glasses t.nd t. show l arger lags of accommodat.on t.an emmet.opic children, but.t.e lags of accommodat.ion are usually reduced by t.eir spect.cle undercorrect.on.

关键词：正视眼调节反应屈光不正观察目标外隐斜顶距

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