Effect of sumatriptan on gastric emptying:A crossover study using the BreathID system
Effect of sumatriptan on gastric emptying:A crossover study using the BreathID system作者机构:Gastroenterology DivisionYokohama City University Hospital3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Department of Medical EducationYokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Office of Postgraduate Medical EducationYokohama City University Hospital3-9 FukuuraKanazawakuYokohamaKanagawa 236-0004Japan
出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))
年 卷 期:2012年第18卷第26期
页 面:3415-3419页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
主 题:ID系统 胃排空 监测试验 滞后时间 舒马普坦 控制条件 中位数 回归估计
摘 要:AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover *** subjects fasted overnight and were randomly assigned to receive a test meal(200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg(sumatriptan condition),or the test meal alone(control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the BreathID ***,using Oridion Research Software(β version),the time taken for emptying of 50% of the labeled meal(T 1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal(T lag),the gastric emptying coefficient(GEC),and the regression-estimated constants(β and κ) were *** statistical significance of any differences in the parameters were analyzed using Wilcoxon s signed-rank ***:In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],T lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].There were no significant differences in the GEC or κ between the 2 ***:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.