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Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

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Bioactive Materials 2022年第12期7卷 433-445页

作者： Hyo-Jin Yoon Songhyun Lee Tae Young Kim Seung Eun Yu Hye-Seon Kim Young Shin Chung Seyong Chung Suji Park Yong Cheol Shin Eun Kyung Wang Jihye noh hyun jung Kim Cheol Ryong Ku Hong Koh Chang-Soo Kim Joon-Sang Park Young Min Shin Hak-Joon Sung Department of Medical Engineering Yonsei University College of MedicineSeoul03722Republic of Korea School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Obstetrics and Gynecology Institution of Women’s Life Medical ScienceSeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Biomedical Engineering The University of Texas at AustinAustinTX78712USA Department of Internal Medicine EndocrinologyInstitute of Endocrine ResearchYonsei University College of MedicineSeoul03722Republic of Korea Department of Pediatrics GastroenterologySeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Computer Engineering Hongik UniversitySeoul04066Republic of Korea Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Numais Co. Ltd.Korea Seoul 04799Republic of Korea

All-in-one treatments represent a paradigm shift in future *** example,inflammatory bowel disease(IBD)is mainly diagnosed by endoscopy,which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable ***,molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free *** study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable *** properties enabled spraying of the hydrogel onto the intestinal walls during ***,peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions,specifically by *** peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD ***,the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5(TLR5)as the main target of flagellin binding and *** peptide binding potently suppressed inflammatory signaling without drug loading,where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis *** results were produced using a human colorectal cell line,clinical IBD patient cells,gut-on-a-chip,a mouse IBD model,and pig experiments to validate the translational utility.

关键词： Nanomicelle Injectable hydrogel Peptide display Theranostic All-in-one treatment Inflammatory bowel disease

A Raman Study of the Origin of Oxygen Defects in Hexagonal Manganite Thin Films

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Chinese Physics Letters 2012年第12期29卷 148-151页

作者： CHEN Xiang-Bai HIEN Nguyen Thi Minh YANG In-Sang LEE Daesu noh Tae-Won Department of Nano Science&Mechanical Engineering and Nanotechnology Research Center Konkuk UniversityChungju 380-701Korea 2Department of Physics and Division of Nano-SciencesEwha Womans UniversitySeoul 120-750Korea 3ReCFIDepartment of Physics and AstronomySeoul National UniversitySeoul 151-747Korea

Oxygen defects are usually unavoidable when synthesizing oxide thin *** study the origin of the oxygen defects in hexagonal manganite HoMnO_(3) epitaxial thin films through Raman scattering *** results show that the oxygen defects in hexagonal HoMnO_(3) thin films have distinct effects on different phonon modes and on magnon *** analyses indicate that the oxygen defects in hexagonal HoMnO_(3) thin films mainly originate from the basal O3 and/or O4 oxygen ***,our analyses of oxygen defects predict that the Mn 3d orbitals would be more strongly hybridized with the apical O1 and/or O22p orbitals than the basal O3 and/or O42p *** prediction is consistent with our resonant Raman scattering study and earlier first-principle calculations of the electronic structures of hexagonal manganites.

关键词： spectroscopy. hexagonal Oxygen

Analysis of Interferential Current Therapy-Induced Skin Changes in Healthy Korean Men

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Natural Science 2018年第11期10卷 436-447页

作者： So-jung Kim Seung-Min Yang Ju-hyun Kim Jeong-Uk Lee Mee-Young Kim Lim-Kyu Lee Byoung-Sun Park Won-Deok Lee Ji-Woong noh Yong-Sub Shin Doo-Ho Kim Il-hyun Kim Kong-Sook noh junghwan Kim Laboratory of Health Science & Nanophysiotherapy Department of Physical Therapy Graduate School Yongin Uni-versity Yongin-si Republic of Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan-si Republic of Korea Department of Physical Therapy College of Health Science Honam University Gwangju-si Republic of Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Pow-er Plant Yeongwol-gun Republic of Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin-si Republic of Korea

We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.

关键词： Interferential Current Therapy Korean Men Skin

Comments to young surgeons concerning laparoscopic spleenpreserving D2 lymph node dissection for advanced gastric cancer on the upper body

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Chinese Journal of Cancer Research 2014年第3期26卷 231-233页

作者： Yoon Young Choi Ji Yeong An Woo Jin hyung Sung Hoon noh Department of Surgery Yonsei University Health System Yonsei University College of Medicine

Qualified radical gastrectomy with lymph node dissection is very important to the prognosis of patients with gastric cancer. Now D2 lymph node dissection is standard procedure for gastric cancer surgery, and spleen hilar lymph node dissection is mandatory for gastric cancer in upper body. Because the anatomy of vessels in this area is very complicated, D2 lymph node dissection is technical challenging not only for open gastrectomy but also for laparoscopic one. Adapting a new technique is important to all surgeons, but we surgeons should always consider a patient＇s safety as the most important factor during surgery and that efforts should be based on scientific rationale with oncologic principles. I hope that the recent report by Huang et al. about laparoscopic spleen preserving hilar lymph node dissection would be helpful to young surgeons who will perform laparoscpic total gastrectomy for gastric cancer.

关键词： Gastric cancer lymph node dissection laparoscopy spleen

Development of fault section identification technique for low voltage DC distribution systems by using capacitive discharge current

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Journal of Modern Power Systems and Clean Energy 2018年第3期6卷 509-520页

作者： Chul-Ho noh Chul-Hwan KIM Gi-Hyeon GWON Yun-Sik OH College of Information and Communication Engineering Sungkyunkwan University

The increasing importance of energy efficiency has led to several studies related to the construction of a reliable low voltage DC(LVDC) distribution ***, studies on a protection scheme that considers the fault characteristics of an LVDC distribution system are essential to improve system reliability. When compared to a conventional distribution system, the most distinct feature of an LVDC distribution system is the existence of a capacitive discharge current from converters under a fault condition that results in the prompt operation of protection devices. Therefore, this study involves proposing a precise and rapid technique to identify the fault section in an LVDC distribution system. The technique involves two stages, namely: an analysis stage to analyze the capacitive discharge current and a decision stage to identify the fault section based on the fault type. A detailed discussion of each step is presented and its feasibility is verified based on the results of simulations with an ElectroMagnetic Transients Program and MATLAB~?.

关键词： Capacitive discharge current Fault section identification Fault type identification Low voltage DC distribution system

Performance evaluations on inner vs. outer decomposition first parallel join algorithms for two nested loop joins

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Journal of Central South University 2014年第10期21卷 3873-3882页

作者： Seo-Young noh Heejun YOON Il-Yeon YEO Yoon-su JEONG hyungwoo PARK National Institute of Supercomputing and Networking Korea Institute of Science and Technology Information Department of Information Communication Engineering Mokwon University

Two popular traditional join algorithms and their parallel versions are introduced. When designing join algorithms in serial computing environment, decomposing inner relation is considered as the right direction to save disk I/Os. However, two different decomposition algorithms are compared, such as inner vs. outer decomposition first algorithms for tuple-based and block-based nested loop joins, showing that the proposed approach is 20% better than general approach. Also lemmas are proved, when we have to use the outer decomposition first parallel join algorithms.

关键词： parallel join performance inner decomposition outer decomposition

Implanting a preferential solid electrolyte interphase layer over anode electrode of lithium ion batteries for highly enhanced Li^+ diffusion properties

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Journal of Energy Chemistry 2020年第9期29卷 285-292,I0009页

作者： Ye Kyu Kim Yoongon Kim Jaejin Bae hyunwoo Ahn Yuseong noh hyunsu Han Won Bae Kim Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Nam-gu 37673PohangSouth Korea

The lithium-ion batteries are recognized as the most promising energy storage system,but it still does not meet the power requirements of electric vehicle batteries owing to low volumetric energy density with the traditional graphite electrode *** this study,we report the development of a novel electrode system fabricated by implantation of a solid electrolyte interphase(SEI)layer on the graphite *** SEI-implanted graphite electrode is made using a lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)-based electrolyte and cycled with a lithium tetrafluoroborate LiBF4-based *** new electrode system shows significantly enhanced electrochemical properties owing to the rapid and efficient diffusion of Li ions through the SEI layer between the electrolyte and *** graphite electrode with its pre-formed SEI layer achieves a reversible capacity of 357 mAh g^-1 at 0.5 C after 50 cycles,which is significantly higher than that of commercial lithium-ion battery systems constructed with LiPF6(312mAh g^-1).The resulting unique electrode system could present a new avenue in SEI research for highperformance lithium-ion batteries.

关键词： SEI layer Graphite Implanting Li ion diffusion LiTFSI LiBF4 Artificial Mobility

Evaluation of Underwater Optical-Acoustic Hybrid Network

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China Communications 2014年第5期11卷 49-59页

作者： Seongwon Han Youngtae noh Richard Liang Roy Chen Yung-Ju Cheng Mario Gerla Computer Science University of California Los Angeles CA 90095 USA Cisco Systems Inc. Milpitas CA 95134 USA

The deployment of underwater networks allows researchers to collect explorative and monitoring data on underwater *** acoustic medium has been widely adopted in current research and commercial uses,while the optical medium remains experimental *** to our survey onthe properties of acoustic and optical communicationsand preliminary simulation results have shown significant trade-offs between bandwidth,propagation delay,power consumption,and effective communication *** propose a hybrid solution that combines the use of acoustic and optical communication in order to overcome the bandwidth limitation of the acoustic channel by enabling optical communicationwith the help of acoustic-assisted alignment between optical transmitters and receivers.

关键词： optical communication acoustic communication underwater

SARS-CoV-2-induced liver injury:A review article on the high-risk populations,manifestations,mechanisms,pathological changes,management,and outcomes

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World Journal of Gastroenterology 2022年第39期28卷 5723-5730页

作者： Alvin Oliver Payus Malehah Mohd noh Nornazirah Azizan Raman Muthukaruppan Chettiar Department of Medicine Faculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400SabahMalaysia Department of Pathobiology and Medical Diagnostic Faculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Department of Medicine Hospital Queen Elizabeth Ⅰ13aJalan PenampangKota Kinabalu 88200Malaysia

The novel coronavirus disease 2019 is an infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and was declared a global pandemic with more than 500 million reported cases and more than 6 million deaths worldwide to *** it has transitioned into the endemic phase in many countries,the mortality rate and overall prognosis of the disease are still abysmal and need further *** has been evidence that shows the significance of SARS-CoV-2-related liver ***,we review the literature on the various spectrum of SARS-CoV-2 infection-induced liver injury and the possible mechanisms of damage to the hepatobiliary *** review aimed to illustrate the latest understanding regarding SARS-CoV-2-induced liver injury including the high-risk populations,the characteristic clinical manifestations,the possible pathogenic mechanism,the pathological changes,the current suggestions for clinical treatment for various spectrum of populations,and the prognosis of the *** conclusion,SARS-CoV-2 patients with a liver injury warrant close monitoring as it is associated with the more severe and poorer outcome of the infection.

关键词： COVID-19 SARS-CoV-2 Pandemic Liver injury Pandemics Prognosis