Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

作     者：Hyo-Jin Yoon Songhyun Lee Tae Young Kim Seung Eun Yu Hye-Seon Kim Young Shin Chung Seyong Chung Suji Park Yong Cheol Shin Eun Kyung Wang Jihye Noh Hyun Jung Kim Cheol Ryong Ku Hong Koh Chang-Soo Kim Joon-Sang Park Young Min Shin Hak-Joon Sung 

作者机构：Department of Medical EngineeringYonsei University College of MedicineSeoul03722Republic of Korea School of Electrical and Electronic EngineeringYonsei UniversitySeoul03722Republic of Korea Department of Obstetrics and GynecologyInstitution of Women’s Life Medical ScienceSeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Biomedical EngineeringThe University of Texas at AustinAustinTX78712USA Department of Internal MedicineEndocrinologyInstitute of Endocrine ResearchYonsei University College of MedicineSeoul03722Republic of Korea Department of PediatricsGastroenterologySeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Computer EngineeringHongik UniversitySeoul04066Republic of Korea Institute of Tissue Regeneration Engineering(ITREN)Dankook UniversityCheonan31116Republic of Korea Numais Co.Ltd.Korea Seoul 04799Republic of Korea 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第12期

页      面：433-445页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Bio & Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) to H.- J.S the Korea Medical Device Development Fund Grant funded by the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health & Welfare,the Ministry of Food and Drug Safety to H.-J.S partly by the Starting Growth Technological R&D program of SMBA to C.-S.K partially by the National Cancer Institute of the National Institutes of Health to H.J.K 

主　　题：Nanomicelle Injectable hydrogel Peptide display Theranostic All-in-one treatment Inflammatory bowel disease 

摘      要：All-in-one treatments represent a paradigm shift in future *** example,inflammatory bowel disease(IBD)is mainly diagnosed by endoscopy,which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable ***,molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free *** study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable *** properties enabled spraying of the hydrogel onto the intestinal walls during ***,peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions,specifically by *** peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD ***,the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5(TLR5)as the main target of flagellin binding and *** peptide binding potently suppressed inflammatory signaling without drug loading,where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis *** results were produced using a human colorectal cell line,clinical IBD patient cells,gut-on-a-chip,a mouse IBD model,and pig experiments to validate the translational utility.