SARS-CoV-2-induced liver injury:A review article on the high-risk populations,manifestations,mechanisms,pathological changes,management,and outcomes

作     者：Alvin Oliver Payus Malehah Mohd Noh Nornazirah Azizan Raman Muthukaruppan Chettiar 

作者机构：Department of MedicineFaculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400SabahMalaysia Department of Pathobiology and Medical DiagnosticFaculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Department of MedicineHospital Queen Elizabeth Ⅰ13aJalan PenampangKota Kinabalu 88200Malaysia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第39期

页      面：5723-5730页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：COVID-19 SARS-CoV-2 Pandemic Liver injury Pandemics Prognosis 

摘      要：The novel coronavirus disease 2019 is an infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and was declared a global pandemic with more than 500 million reported cases and more than 6 million deaths worldwide to *** it has transitioned into the endemic phase in many countries,the mortality rate and overall prognosis of the disease are still abysmal and need further *** has been evidence that shows the significance of SARS-CoV-2-related liver ***,we review the literature on the various spectrum of SARS-CoV-2 infection-induced liver injury and the possible mechanisms of damage to the hepatobiliary *** review aimed to illustrate the latest understanding regarding SARS-CoV-2-induced liver injury including the high-risk populations,the characteristic clinical manifestations,the possible pathogenic mechanism,the pathological changes,the current suggestions for clinical treatment for various spectrum of populations,and the prognosis of the *** conclusion,SARS-CoV-2 patients with a liver injury warrant close monitoring as it is associated with the more severe and poorer outcome of the infection.