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Chemical reactions and thermal stress induced microstructure evolution in 2D-C_(f)/ZrB_(2)-SiC composites

Journal of Materials Science & Technology 2021年第24期83卷 75-82页

作者： Bo-Wen Chen De-Wei Ni Chun-Jing Liao You-Lin jiang jun Lu Yu-Sheng Ding Hong-Da Wang Shao-Ming Dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Fibers degradation and matrix cracks are very common during fabrication of composites,which seriously reduces the reliability and properties of the *** this work,2 D-C_(f)/Zr B_(2)-Si C composites were fabricated by a joint processing of slurry infiltration and hot *** on thermal kinetics calculation,finite element simulation and detailed microstructure characterization,fibers degradation and matrix cracks formation mechanisms of the composites are discussed and *** impurities including SiO_(2)and ZrO_(2)react with carbon fibers,resulting in formation of Zr C,Si C particles and etching pits on the fibers,which also leads to a strong bonding between the fibers and *** the other hand,thermal expansion mismatch between the fibers and matrix gives rise to serious thermal stress in the *** thermal stress distribution and development are analyzed by finite element simulation,which is in good agreement with the cracks’formation in the *** on the revealed microstructure evolution mechanisms,a potential solution to mitigate fibers degradation and matrix cracks is put forward.

关键词： Ceramic matrix composites Carbon fiber Residual stress

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Genotype distribution and evolutionary analysis of rotavirus associated with acute diarrhea outpatients in Hubei,China,2013–2016

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Virologica Sinica 2022年第4期37卷 503-512页

作者： Ting Zhang Jing Li Yong-Zhong jiang jun-Qiang Xu Xu-Hua Guan Li-Qiang Wang Jie Chen Yi Liang Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhan430072China Hubei Provincial Center for Disease Control and Prevention Wuhan430079China

Group A human rotaviruses(RVAs)annually cause the deaths of 215,000 infants and young *** understand the epidemiological characteristics and genetic evolution of RVAs,we performed sentinel surveillance on RVA prevalence in a rotavirus-surveillance network in Hubei,*** 2013 to 2016,a total of 2007 fecal samples from hospital outpatients with acute gastroenteritis were collected from four cities of Hubei *** the 2007 samples,153(7.62%)were identified positive for RVA by real-time *** infection in Hubei mainly occurred in autumn and *** highest detection rate of RVA infection was in 1–2 years old of outpatients(16.97%).No significant difference of RVA positive rate was observed between females and *** performed a phylogenetic analysis of the G/P genotypes based on the partial VP7/VP4 gene sequences of RVAs.G9P[8]was the most predominant strain in all four years but the prevalence of G2P[4]genotype increased rapidly since *** reconstructed the evolutionary time scale of RVAs in Hubei,and found that the evolutionary rates of the G9,G2,P[8],and P[4]genotypes of RVA were 1.069×10^(-3),1.029×10^(-3),1.283×10^(-3)and 1.172×10^(-3)nucleotide substitutions/site/year,***,using a molecular clock model,we showed that most G9,G2,P[8],and P[4]genotype strains dated from the recent ancestor in 2005,2005,1993,and 2013,*** finding of the distribution of RVAs in infants and young children in Hubei Province will contribute to the understanding of the epidemiological characteristics and genetic evolution of RVAs in China.

关键词： Group A human rotavirus(RVA) Prevalence Phylogenetic analysis Evolution Hubei Province

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NiS_(2)/FeS Heterostructured Nanoflowers for High-Performance Sodium Storage

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Energy Material Advances 2023年第1期4卷 57-66页

作者： Dong Yan Shuhao Xiao Xinyan Li Jinxia jiang Qiyuan He Hanchao Li Jiaqian Qin Rui Wu Xiaobin Niu jun Song Chen Institute for Advanced Study Chengdu UniversityChengdu 610106P.R.China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054P.R.China Chongqing Medical and Pharmaceutical College Chongqing 401331P.R.China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina Center of Excellence on Advanced Materials for Energy Storage Metallurgy and Materials Science Research InstituteChulalongkorn UniversityBangkok 10330Thailand Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhenP.R.China

Transition metal sulfides demonstrate attractive potential for sodium storage owing to their high theoretical specific capacity and high ***,the low conductivity and volume expansion deteriorate their high-rate performance and cycling *** this work,we construct NiS_(2)/FeS heterostructure by growing Ni-based layered double hydroxide nanosheets on Fe-based Prussian Blue nanocrystals followed by gaseous sulfurization,giving rise to flower-like NiS_(2)/FeS *** as-prepared nanocomposite exhibits good rate performance of 156 mAh g^(−1) at 50 A g^(-1) and long cycle life of 606 mAh g^(−1) at 5 A g^(−1) after 1,000 cycles,which are superior to the heterostructure-free counterpart of NiS_(2) and *** functional theory calculation further verifies that the enhanced electrochemical performance of NiS_(2)/FeS is due to the existence of interface derived from the heterostructure.

关键词： flowers attractive cycling

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Compensatory function of bradykinin B1 receptor in the inhibitory effect of captopril on cardiomyocyte hypertrophy and cardiac fibroblast proliferation in neonatal rats

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Chinese Medical Journal 2008年第13期121卷 1220-1225页

作者： ZOU jun REN jiang-hua FENG Dan WANG Hong XU jiang Department of Cardiology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China Department of Physiology Medical College of Wuhan University Wuhan Hubei 430071 China

Background Bradykinin （BK） acts mainly on two receptor subtypes： B1 and B2, and activation of B2 receptor mediates the most well-known cardioprotective effects of angiotensin converting enzyme inhibitors （ACEi）, however, the role that B1 receptor plays in ACEi has not been fully defined. We examined the role of B1 receptor in the inhibitory effect of ACE inhibitor captopril on rat cardiomyocyte hypertrophy and cardiac fibroblast proliferation induced by angiotensin Ⅱ （Ang Ⅱ） and explored its possible mechanism. Methods Neonatal cardiomyocytes and cardiac fibroblasts （CFs） were randomly treated with Ang Ⅱ, captopdl, B2 receptor antagonist （HOE-140） and B1 receptor antagonist （des-Arg^10, Leu^9-kallidin） alone or in combination. Flow cytometry was used to evaluate cell cycle, size and protein content. Nitric oxide （NO） and intracellular cyclic guanosine monophosphate （cGMP） level were measured by colorimetry and radioimmunoassay. Results After the CFs and cardiomyocytes were incubated with 0.1 μmol/L Ang Ⅱ for 48 hours, the percentage of CFs in the S stage, cardiomyocytes size and protein content significantly increased （both P 〈0.01 vs control）, and these increases were inhibited by 10 μmol/L captopril. However, NO and cGMP levels were significantly higher than that with Ang Ⅱ alone （both P 〈0.01）. 1 μmol/L HOE-140 or 0.1 pmol/L des-Arg^10, Leu^9-kallidin attenuated the effects of captopril, which was blunted further by blockade of both B1 and B2 receptors. Conclusions Acting via B2 receptor, BK contributes to the antihypertrophic and antiproliferative effects of captopril on cardiomyocytes and CFs. In the absence of B2 receptor, B1 receptor may act a compensatory mechanism for the B2 receptor and contribute to the inhibition of cardiomyocyte hypertrophy and CFs proliferation by captopril. NO and cGMP play an important role in the effect of B1 receptor.

关键词： bradykinin captopril cardiac fibroblast cardiomyocyte

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Roles of furfural during the thermal treatment of bio-oil at low temperatures

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Journal of Energy Chemistry 2020年第11期29卷 85-95页

作者： Zhe Xiong Yuanjing Chen Muhammad Mufti Azis Xun Hu Wei Deng Hengda Han Long jiang Sheng Su Song Hu Yi Wang jun Xiang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina Chemical Engineering Department Faculty of EngineeringGadjah Mada UniversityYogyakarta 55281Indonesia School of Material Science and Engineering University of JinanJinan 250022ShandongChina China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan 430074HubeiChina

The reactive O-containing species in bio-oil could induce the polymerization of bio-oil during its thermal treatment, which affects the relevant utilization of bio-oil significantly. Furans, as the highly reactive Ocontaining species in bio-oil, play important roles during the thermal treatment of bio-oil. In this study,furfural was chosen as the representative of the furans in bio-oil to investigate its roles during the thermal treatment of bio-oil. The raw bio-oil with and without the addition of extra furfural(10 wt% of bio-oil) and pure furfural were pyrolyzed in a fixed-bed reactor at 200–500 ℃. The results show that the interactions among furfural and bio-oil components can take place prior to the evaporation of furfural(<140 ℃) to form the intermediates, then these intermediates could be further polymerized to form large molecular compounds, and coke can be formed via the interactions at temperatures ≥ 300 ℃. At temperatures ≤ 300 ℃, furfural mainly interacts with anhydrosugars. As the temperature further increases, the aromatics are involved in the interactions to form coke. The increased percentage of the coke formed via the interactions is in a linear relation with the conversion of furfural during the pyrolysis at 300–500 ℃(no coke formed at 200 ℃). Meanwhile, more non-aromatic light components(≤ C6) and less aromatics in the tars could be formed due to the interactions.

关键词： Bio-oil Furfural Aromatic Coke Polymerization Interaction

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Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment

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世界精神病学杂志 2023年第9期13卷 630-644页

作者： Zheng Wang Xue-ning Li Shao-Nan Yang Yuan Wang Ke-Jin Gao Bin Han Ai-jun Ma Department of Internal Medicine-Neurology Affiliated Hospital of Qingdao UniversityQingdao 266001Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdao 266001Shandong ProvinceChina

BACKGROUND Exosomal miRNAs play crucial roles in many central nervous system *** small vessel disease(CVSD)is a small vessel disease that is affected by various *** study aimed to investigate the role of exosomal miR-320e in the Wnt/β-catenin pathway stimulated by oxidative stress and assess its clinical correlation with psychiatric symptoms in patients with *** To explore whether exosomal miR-320e could suppress the Wnt/β-catenin pathway and play a protective role in CVSD progression,as well as examine its potential correlation with cognitive impairment and depression in patients with *** Differentially expressed exosomal miRNAs were filtered by sequencing plasma exosomes from patients with CVSD and healthy *** and dual luciferase analyses were used to confirm the binding of miR-320e to Wnt2,and the mRNA and protein levels of downstream components in the Wnt/β-catenin pathway were evaluated when overexpressed or with knockdown of miR-320e under H2O2-induced oxidative *** addition,Wnt2-targeting siRNA was used to confirm the role of miR-320e in the Wnt2-mediated inhibition of the Wnt/β-catenin pathway.A retrospective analysis was conducted among patients with CVSD to confirm the correlation between miR-320e expression and the severity of cognitive impairment and depression,which were quantified using the Montreal Cognitive Assessment(MoCA)/Executive Function Assessment(EFA),and the Hamilton Depression Scale(HAMD)/Beck Depression Inventory(BDI),*** High-throughput sequencing revealed that exosomal miR-320e was downregulated in patients with *** analysis and dual-luciferase reporter gene experiments showed that exosomal miR-320e inhibited the Wnt/β-catenin pathway in response to oxidative stress by targeting the 3'noncoding region of *** of exosomes carrying miR-320e into endothelial cells could also target Wnt2 and inhibit the Wnt2/β-catenin *** miR-32

关键词： Exosome Cerebral small vessel disease miRNA-320e Wnt2 Wnt/β-catenin pathway Depressed

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特勤人员缺血性心血管病发病风险初步调查及其与行为生活方式的相关性研究

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海军医学杂志 2024年第8期45卷 800-805页

作者：骆芝英邹杰张荷刘君蒋晓霞王炜芳空军杭州特勤疗养中心疗养三区浙江杭州310002 联勤保障部队第九〇三医院药剂科

目的研究特勤人员缺血性心血管病(ICVD)发病风险与行为生活方式的相关性,为特勤人员的健康干预提供有针对性的参考依据,从而降低ICVD的发生,保证特勤人员战斗力。方法收集2019年1月至2021年12月在杭州某疗养院疗养与体检的特勤人员共120... 详细信息

目的研究特勤人员缺血性心血管病(ICVD)发病风险与行为生活方式的相关性,为特勤人员的健康干预提供有针对性的参考依据,从而降低ICVD的发生,保证特勤人员战斗力。方法收集2019年1月至2021年12月在杭州某疗养院疗养与体检的特勤人员共1205例的健康档案数据并整理,采用自制健康行为生活方式问卷调查表,由专业人员指导填写并完成问卷。结果不同年龄段特勤人员吸烟率、糖尿病及高胆固醇血症发生率差异有统计学意义(χ^(2)=13.481,P=0.009;χ^(2)=13.888,P=0.008;χ^(2)=24.505,P<0.001),体重指数(BMI)≥24及收缩压≥140 mmHg(1 mmHg≈0.133 kPa)的发生率在不同年龄段差异无统计学意义(χ^(2)=9.247,P=0.055;χ^(2)=2.400,P=0.663)。特勤人员未来10年ICVD发病绝对危险均值为(1.44±1.30)%,未来10年ICVD发病绝对危险为中危的有1例,占0.08%,低危的有37例,占3.07%,极低危有1167例,占96.85%;随着年龄的增加,未来10年ICVD发病相对危险为高风险的发生率递增,差异有统计学意义(χ^(2)=25.774,P<0.001)。特勤人员未来10年ICVD发病相对危险与行为生活方式的相关比较中,鱼类及水产品平均日摄入量、蛋类及蛋制品平均日摄入量、平均每周吃早餐的天数、平均每周运动锻炼时间、平均每周被动吸烟情况、饮酒年数之间差异有统计学意义(F=9.794,P=0.002;F=7.523,P=0.006;F=5.622,P=0.018;F=5.955,P=0.015;F=4.777,P=0.029;F=18.946,P<0.001)。鱼类及水产品平均日摄入量越多、饮酒的年数越多,相对风险越高,是危险因素(OR=1.330,P=0.004;OR=1.482,P<0.001);平均每周吃早餐的天数越多,相对风险越低,是保护因素(OR=0.772,P=0.024)。结论特勤人员健康行为生活方式的养成对于预防ICVD具有重要意义。随着年龄的增加,ICVD发病相对危险为高风险的发生率也随之递增。养成良好的生活饮食习惯,每天吃早餐、合理膳食、戒烟限酒对于预防ICVD具有一定的保护作用。

关键词：特勤人员缺血性心血管病行为生活方式

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混合级联特高压直流输电系统逆变站保护功能及闭锁策略设计

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浙江电力 2024年第10期43卷 103-113页

作者：唐俊赵文强姜崇学卢宇卢亚军徐莹南京南瑞继保电气有限公司南京211102 国网经济技术研究院有限公司北京102209

针对混合级联特高压直流输电系统的逆变站,基于其一次拓扑结构,按照保护无死区、故障易定位的原则,结合测量互感器的安装位置,提出了保护的分区建议和配置方案。根据逆变站故障发生的位置及严重程度,以快速切除故障、减少停运范围为目标... 详细信息

针对混合级联特高压直流输电系统的逆变站,基于其一次拓扑结构,按照保护无死区、故障易定位的原则,结合测量互感器的安装位置,提出了保护的分区建议和配置方案。根据逆变站故障发生的位置及严重程度,以快速切除故障、减少停运范围为目标,提出包括LCC(电网换相换流器)闭锁、单MMC(模块化多电平换流器)闭锁、MMC整体闭锁、顺序极闭锁和分步极闭锁的分级闭锁策略。以白鹤滩-江苏混合级联特高压直流输电工程实际的控制保护装置和按照工程成套参数建立的RTDS(实时仿真系统)模型组建了实时闭环仿真系统,通过仿真验证了所提保护方案和闭锁策略的可行性和有效性。

关键词：混合级联系统特高压直流输电保护配置闭锁策略电网换相换流器模块化多电平换流器

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Mutations in FgPrp6 suppressive to the Fgprp4 mutant in Fusarium graminearum

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Journal of Integrative Agriculture 2022年第5期21卷 1375-1388页

作者： LI Chao-hui FAN Zhi-li HUANG Xin-yi WANG Qin-hu jiang Cong XU Jin-rong JIN Qiao-jun NWAFU-PU Joint Research Center/State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYang ling 712100P.R.China Institute of Plant Protection/jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology Jiangsu Academy of Agricultural SciencesNanjing 210014P.R.China Department of Botany and Plant Pathology Purdue UniversityWest LafayetteIN47907USA

The pre-mRNA processing factor Prp6 is an essential component of the U4/U6.U5 tri-small nuclear ribonucleoprotein(snRNP).In a previous study,mutations were identified in the PRP6 ortholog in four suppressors of Fgprp4 that was deleted of the only kinase FgPrp4 among the spliceosome components in the plant pathogenic fungus Fusarium *** this study,we identified additional suppressor mutations in FgPrp6 and determined the suppressive effects of selected *** total,12 mutations of FgPRP6 were identified in 20 suppressors of Fgprp4 by sequencing *** three mutation sites are in the linker region of FgPrp6,seven are in the first two HAT ***-seq analysis showed that suppressor mutations on different sites caused different splicing efficiency *** suppressive effects of E308K and R230H were *** to human and fission yeast,the FgPrp6 was phosphorylated by the FgPrp4 ***,the conserved Prp4-phosphorylation sites T261,T219&T221,and predicted phosphorylation sites T199&T200 on FgPrp6 were dispensable for the function of FgPrp6 in hyphal growth and sexual reproduction but important in plant *** are required for the infectious growth of *** in wheat ***-seq analysis of the wheat lemma infected with Fgprp6/FgPRP6^(Δ199-221)-GFP or Fgprp6/FgPRP6^(Δ250-262)-GFP showed that 28 and 35% introns had splicing defects,respectively,which may be responsible for their defects in plant infection.

关键词： RNA splicing FgPrp6 suppressor plant infection phosphorylation

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Multidifferentiation potential of dental-derived stem cells

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World Journal of Stem Cells 2021年第5期13卷 342-365页

作者： Jing-Yao Yin Xing-Hong Luo Wei-Qing Feng Sheng-Hong Miao Ting-Ting ning Qian Lei Tao jiang Dan-Dan Ma Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endodontics Stomatological HospitalSouthern Medical UniversityGuangzhou 510280Guangdong ProvinceChina

Tooth-related diseases and tooth loss are widespread and are a major public health *** loss of teeth can affect chewing,speech,appearance and even ***,the science of tooth regeneration has emerged,and attention has focused on tooth regeneration based on the principles of tooth development and stem cells combined with tissue engineering *** undifferentiated stem cells in normal tooth tissues,dental mesenchymal stem cells(DMSCs),which are a desirable source of autologous stem cells,play a significant role in tooth *** hope to reconstruct the complete tooth tissues with normal functions and vascularization by utilizing the odontogenic differentiation potential of ***,DMSCs also have the ability to differentiate towards cells of other tissue types due to their *** review focuses on the multipotential capacity of DMSCs to differentiate into various tissues,such as bone,cartilage,tendon,vessels,neural tissues,muscle-like tissues,hepatic-like tissues,eye tissues and glands and the influence of various regulatory factors,such as non-coding RNAs,signaling pathways,inflammation,aging and exosomes,on the odontogenic/osteogenic differentiation of DMSCs in tooth *** application of DMSCs in regenerative medicine and tissue engineering will be improved if the differentiation characteristics of DMSCs can be fully utilized,and the factors that regulate their differentiation can be well controlled.

关键词： Dental mesenchymal stem cells Regenerative medicine Tissue engineering Multipotency Odontogenic differentiation Osteogenic differentiation

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