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Mutations in FgPrp6 suppressive to the Fgprp4 mutant in Fusarium graminearum

Mutations in FgPrp6 suppressive to the Fgprp4 mutant in Fusarium graminearum

作     者:LI Chao-hui FAN Zhi-li HUANG Xin-yi WANG Qin-hu JIANG Cong XU Jin-rong JIN Qiao-jun LI Chao-hui;FAN Zhi-li;HUANG Xin-yi;WANG Qin-hu;JIANG Cong;XU Jin-rong;JIN Qiao-jun

作者机构:NWAFU-PU Joint Research Center/State Key Laboratory of Crop Stress Biology for Arid AreasCollege of Plant ProtectionNorthwest A&F UniversityYang ling 712100P.R.China Institute of Plant Protection/Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and TechnologyJiangsu Academy of Agricultural SciencesNanjing 210014P.R.China Department of Botany and Plant PathologyPurdue UniversityWest LafayetteIN47907USA 

出 版 物:《Journal of Integrative Agriculture》 (农业科学学报(英文版))

年 卷 期:2022年第21卷第5期

页      面:1375-1388页

核心收录:

学科分类:09[农学] 0904[农学-植物保护] 090401[农学-植物病理学] 

基  金:supported by the grants from the National Natural Science Foundation of China(31600117) the Natural Science Basic Research Program of Shaanxi,China(2020JM-165) 

主  题:RNA splicing FgPrp6 suppressor plant infection phosphorylation 

摘      要:The pre-mRNA processing factor Prp6 is an essential component of the U4/U6.U5 tri-small nuclear ribonucleoprotein(snRNP).In a previous study,mutations were identified in the PRP6 ortholog in four suppressors of Fgprp4 that was deleted of the only kinase FgPrp4 among the spliceosome components in the plant pathogenic fungus Fusarium *** this study,we identified additional suppressor mutations in FgPrp6 and determined the suppressive effects of selected *** total,12 mutations of FgPRP6 were identified in 20 suppressors of Fgprp4 by sequencing *** three mutation sites are in the linker region of FgPrp6,seven are in the first two HAT ***-seq analysis showed that suppressor mutations on different sites caused different splicing efficiency *** suppressive effects of E308K and R230H were *** to human and fission yeast,the FgPrp6 was phosphorylated by the FgPrp4 ***,the conserved Prp4-phosphorylation sites T261,T219&T221,and predicted phosphorylation sites T199&T200 on FgPrp6 were dispensable for the function of FgPrp6 in hyphal growth and sexual reproduction but important in plant *** are required for the infectious growth of *** in wheat ***-seq analysis of the wheat lemma infected with Fgprp6/FgPRP6^(Δ199-221)-GFP or Fgprp6/FgPRP6^(Δ250-262)-GFP showed that 28 and 35% introns had splicing defects,respectively,which may be responsible for their defects in plant infection.

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