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Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease

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Neuroscience Bulletin 2018年第2期34卷 382-384页

作者： ning Song Junxia Xie Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology Medical College of Qingdao University Institute of Brain Science and Disease Qingdao University

Parkinson’s disease(PD)is recognized as the second most common neurodegenerative disorder after Alzheimer disease.Although a fascinating 200-year journey of research has revealed the multifaceted nature of PD[1,2],its fundamental features are the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc)and depletion of dopamine(DA)in the striatum.Iron accumulates in normal brains with aging.Such

关键词： In Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson’s Disease and Dopamine

Alpha-Synuclein Handling by Microglia: Activating, Combating,and Worsening

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Neuroscience Bulletin 2021年第5期37卷 751-753页

作者： ning Song Leilei Chen Junxia Xie Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersSchool of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and Disease Qingdao University<Qingdao 266071China

Neuroinflammation and a-synuclein (a-syn) aggregation are both neuropathological hallmarks of Parkinson’s disease (PD). Microglia are crucial participants in eliciting neuroinflammatory responses themselves, as well as modulating neurotoxic activity in astrocytes, therefore forming a pathway to neurodegeneration induced by both central and peripheral insults [1, 2].

关键词： Alpha inflammation Combat

Stress Path Analysis of Deep-Sea Sediments Under the Compression-Shear Coupling Load of Crawler Collectors

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Journal of Ocean University of China 2023年第1期22卷 65-74页

作者： ZHANG ning MA ning YIN Shiyang CHEN Xuguang song Yuheng School of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing 102206China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Laboratory for Marine Geology Qingdao National Laboratory for Maine Science and TechnologyQingdao 266100China

The mechanical properties of deep-sea sediments during the driving process of crawler collectors are essential factors in the design of mining systems.In this study,a crawler load is divided into a normal compression load and a horizontal shear load.Then,the internal stress state of sedimentary soil is examined through a theoretical calculation and finite element numerical simulation.Finally,the driving of crawlers is simulated by changing the relative spatial position between the load and stress unit,obtaining the stress path of the soil unit.Based on the calculation results,the effect of the horizontal shear load on the soil stress response is analyzed at different depths,and the spatial variation law of the soil stress path is examined.The results demonstrate that the horizontal shear load has a significant effect on the rotation of the principal stress,and the reverse rotation of the principal stress axis becomes obvious with the increase in the burial depth.The stress path curve of the soil is different at various depths.The spatial variation rule of the stress path of the shallow soil is complex,whereas the stress path curve of the deep soil tends to shrink as the depth increases.The stress path of the corresponding depth should be selected according to the actual research purpose and applied to the laboratory test.

关键词： deep-sea sediment crawler collector compression-shear coupling load stress path principal stress axis direction

Multi-attribute wearable pressure sensor based on multilayered modulation with high constant sensitivity over a wide range

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Nano Research 2023年第5期16卷 7583-7592页

作者： ning Li song Gao Yang Li Jianwen Liu Wenhao song Guozhen Shen School of Information Science and Engineering University of JinanJinan 250022China Shandong Provincial Key Laboratory of Network Based Intelligent Computing University of JinanJinan 250022China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China School of Aeronautical and Astronautical Engineering Purdue University West LafayetteIN 47907USA

Flexible pressure sensors capable of monitoring diverse physiological signals and body movements have garnered tremendous attention in wearable electronic devices.Thereinto,high constant sensitivity over a wide pressure range combined with breathability,biocompatibility,biodegradability is pivotal for manufacturing of reliable pressure sensors in practical sensing applications.In this work,inspired by the multilayered structure of skin epidermis,we propose and demonstrate a multi-attribute wearable piezoresistive pressure sensor consisting of multilayered gradient conductive poly(ε-caprolactone)nanofiber membranes composites.In response to externally applied pressure,a layer-by-layer current path is activated inside the multilayered membranes composites,leading to the most salient sensing performance of high constant sensitivity of 33.955 kPa^(−1) within the pressure range of 0–80 kPa.The proposed pressure sensor also exhibits a fast response–relaxation time,a low detection limit,excellent stability,which can be successfully used to measure human physiological signals.Lastly,an integrated sensor array system that can locate objects’positions is constructed and applied to simulate sitting posture monitoring.These results indicate that the proposed pressure sensor holds great potential in health monitoring and wearable electronic devices.

关键词： wearable pressure sensors multilayer structure high constant sensitivity multi-attribute physiological signals monitoring

Investigation on hydrate growth at the oil–water interface:In the presence of asphaltene

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Chinese Journal of Chemical Engineering 2022年第5期35卷 211-218页

作者： Guangchun song Yuanxing ning Yuxing Li Wuchang Wang Shandong Key Laboratory of Oil-Gas Storage and Transportation Safety College of Pipeline and Civil EngineeringChina University of PetroleumQingdao 266580China State Key Laboratory of Natural Gas Hydrates Beijing 100028China

Natural gas hydrates can readily form in deep-water oil production processes and pose a great threat to the oil industry.Moreover,the coexistence of hydrate and asphaltene can result in more severe challenges to subsea flow assurance.In order to study the effects of asphaltene on hydrate growth at the oil-water interface,a series of micro-experiments were conducted in a self-made reactor,where hydrates nucleated and grew on the surface of a water droplet immersed in asphaltene-containing oil.Based on the micro-observations,the shape and growth rate of the hydrate shell formed at the oil-water interface were mainly investigated and the effects of asphaltene on hydrate growth were analyzed.According to the experimental results,the shape of the water droplet and the interfacial area changed significantly after the formation of the hydrate shell when the asphaltene concentration was higher than a certain value.A mechanism related to the reduction of the interfacial tension caused by the absorption of asphaltenes on the interface was proposed for illustration.Moreover,the growth rate of the hydrate shell decreased significantly with the increasing asphaltene concentration under experimental conditions.The conclusions of this paper could provide preliminary insight how asphaltene affect hydrate growth at the oil-water interface.

关键词： Hydrate Asphaltene Interface Growth Shape

Enhanced secure medical data sharing with traceable and direct revocation

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The Journal of China Universities of Posts and Telecommunications 2023年第1期30卷 66-79页

作者： Peng Weiping Cui Shuang song Cheng Han ning School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo 454003China

Sharing of the electronic medical records among different hospitals raises serious concern of the leakage of individual privacy for the adoption of the semi trustworthiness of the medical cloud platform.The tracking and revocation of malicious users have become urgent problems.To solve these problems,this paper proposed a traceable and directly revocable medical data sharing scheme.In the scheme,a unique identity parameter(ID),which was generated and embedded in the private key generation phase by the medical service provider(MSP),is used to identify legal authorized user and trace malicious user.Only when attributes satisfy the access policy and user’s ID is not in the revocation list can the user calculate the decryption key.Malicious user can be tracked and directly revoked by using the revocation list.Under the assumption of decision bilinear Diffie-Hellman(DBDH),this paper has proved that the scheme is able to achieve security against chosen-plaintext attack(CPA).The performance analysis demonstrates that the sizes of the public key and private key are shorter,and the time overhead is less than other schemes in the public-private key generation,data encryption and data decryption stages.

关键词： medical data sharing electronic medical records tracking and revocation privacy protection

Rh-catalyzed Transient Directing Group Promoted C-H Amidation of Benzaldehydes Utilizing Dioxazolones

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Chinese Journal of Chemistry 2018年第3期36卷 213-216页

作者： Xiaoyang Wang song song ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Rd. 38 Beijing 200192 China State Key Laboratory of Organometallic Chemistry Chinese Academy of Sciences Shanghai 200032 China

Transition-metal catalyzed C--H functionalization of benzaldehydes is of great interest in organic synthesis. Herein, we developed a transient directing group assisted amidation of benzaldehydes catalyzed by rhodium catalyst. With the employment of 10 mol% of 4-trifluoromethyl aniline, the in situ generated imine groups as the directing group efficiently enable this transformation. By using this protocol, a wide range of benzaldehydes were efficiently converted into the corresponding N-（2-formylphenyl）benzamides utilizing dioxazolones as the nitrogen source.

关键词： amidation benzaldehydes rhodium C--H functionalization transient directing group

Plasma membrane lipid scrambling causing phosphatidylserine exposure negatively regulates NK cell activation

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Cellular & Molecular Immunology 2021年第3期18卷 686-697页

作者： ning Wu Hua song Andre Veillette Laboratory of Molecular Oncology Institut de recherches cliniques de Montreal(IRCM)MontrealQC H2W1R7Canada Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and Technology(HUST)WuhanChina Department of Medicine University of MontrealMontrealQC H3C3J7Canada Department of Medicine McGill UniversityMontrealQC H3G 1Y6f Canada

One of the hallmarks of live cells is the asymmetric distribution of lipids across their plasma membrane.Changes in this asymmetry due to lipid"scrambling"result in phosphatidylserine exposure at the cell surface that is detected by annexin V staining.This alteration is observed during cell death processes such as apoptosis,and during physiological responses such as platelet degranulation and membrane repair.Previous studies have shown that activation of NK cells is accompanied by exposure of phosphatidylserine at the cell surface.While this response was thought to be indicative of ongoing NK cell death,it may also reflect the regulation of NK cell activation in the absence of cell death.Herein,we found that NK cell activation was accompanied by rapid phosphatidylserine exposure to an extent proportional to the degree of NK cell activation.Through enforced expression of a lipid scramblase,we provided evidence that activation-induced lipid scrambling in NK cells is reversible and does not lead to cell death.In contrast,lipid scrambling attenuates NKcell activation.This response was accompanied by reduced cell surface expression of activating receptors such as 2B4,and by loss of binding of Src family protein tyrosine kinases Fyn and Lck to the inner leaflet of the plasma membrane.Hence,lipid scrambling during NK cell activation is,at least in part,a physiological response that reduces the NK cell activation level.This effect is due to the ability of lipid scrambling to alter the distribution of membrane-associated receptors and kinases required for NK cell activation.

关键词： NK cell activation Phosphatidylserine exposure Lipid scrambling TMEM16F Signaling

In-situ embedding CoTe catalyst into 1D-2D nitrogen-doped carbon to didirectionally regulate lithium-sulfur batteries

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Nano Research 2022年第10期15卷 8972-8982页

作者： Bin Li Peng Wang Baojuan Xi ning Song Xuguang An Weihua Chen Jinkui Feng Shenglin Xiong Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringState Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Key Laboratory of Mechanical Engineering of Education School of Mechanical EngineeringChengdu UniversityChengdu 610106China Key Laboratory of Material Processing and Mold of Ministry of Education Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Shandong UniversityJinan 250061China

Lithium-sulfur(Li-S)batteries have been widely investigated attributed to their advantages of high energy density and cost effectiveness.However,it is still limited by the uncontrolled shuttle effect of the sulfur cathode and the promiscuous dendrite growth over the lithium anode.To handle the above issues,the highly conductive CoTe catalyst is precisely loaded onto nitrogendoped nanotube and graphene-like carbon(CoTe NCGs),which is employed as a bi-functionally integrated host.On the lithium anode,the CoTe NCGs with excellent lithiophilic property effectively regulate the uniform deposition of lithium and achieve the effect of suppressing the disorderly growth of lithium dendrites.On the sulfur cathode,the electrochemical conversion of lithium polysulfides(LiPSs)is catalyzed to mitigate the notorious shuttle effect.In view of the bifunctionality of CoTe NCGs,the assembled full cell can be steadily stable even for 800 cycles at a high rate of 2 C,and the capacity decay rate is only 0.05%per cycle.The areal capacity of 6.0 mAh·cm^(−2) is well retained after 50 cycles under the conditions of high sulfur loading,poor electrolyte(a low electrolyte-to-sulfur ratio,E/S=4.2),and low negative to positive capacity ratio(N/P=1.6:1).

关键词： CoTe nanocrystals dual-functional shuttling effect lithium dendrite Li-S batteries