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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

Ginkgo biloba supplement modulates mTOR/ERK1/2 activities to mediate cardio-protection in cyclosporin-A-induced cardiotoxicity in Wistar rats

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 32-42页

作者： Jerome Ndudi Asiwe Benneth Ben-Azu Godwin D.Yovwin Vincent-Junior Onoriode Igben Benjamin Oritsemuelebi Israel Ofejiro Efejene Olusegun Gafar Adebayo nicholas Asiwe Anthony Emeka Ojieh Department of Physiology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesUniversity of IbadanIbadan 200223Oyo StateNigeria Department of Pharmacology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Family Medicine Faculty of Clinical MedicineDelta State University330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesNovena UniversityOgume 322103Delta StateNigeria Department of Physiology PAMO University of Medical SciencesPort-HarcourtPort-Harcourt 500262Rivers StateNigeria Department of Anatomy University of Port-HarcourtPort-Harcourt 500262Rivers StateNigeria

Background:Cyclosporine-A(Cs-A),an immunosuppressant drug indicated for organ transplant patients has been associated with toxicities arising from activation of pathological *** Ginkgo biloba supplement(GBS)is an antioxidant-enhancing herbal product widely used for treating neurological and vascular ***:This study investigated the ameliorative effect of GBS on cyclosporine-A induced cardiotoxicity in Wistar ***:The study included 20 Wistar rats(n=5)and they were treated as follows:group 1 received distilled water(10 mL/kg),group 2 received Cs-A(25 mg/kg),group 3 received GBS(50 mg/kg)and group 4 received Cs-A(25 mg/kg)and GBS(50 mg/kg).All treatment were done intraperitoneal for 14 days and thereafter,animals were euthanised and heart tissues were harvested for biochemical assays as well as immunohistochemical *** was also collected for serum biochemical ***:Our results revealed that GBS reduces Cs-A induced increase of AST,ALT,ALP,LDH,and GGT levels in serum relative to Cs-A ***,increased oxido-nitrergic markers like MDA,NO,together with elevated concentrations of cholesterol,triglycerides,LDL,creatine kinase-MB,troponin-I,as well as pro-inflammatory cytokines(IL-6,and TNF-α)and heart weight index were reduced by *** Cs-A induced suppression of low-density lipoprotein,antioxidant(GSH,SOD,CAT),Na-K ATPase activities and antiapoptotic element,Bcl-2 were increased by ***,signalling pathways including ERK1/2,and mTOR as well as ventricular thickness were significantly alleviated by GBS ***:The findings suggest that GBS ameliorated Cs-A-induced cardiotoxicity by activating mTOR/ERK1/2 signalling pathways.

关键词： Apoptosis Antioxidant Cyclosporine-A Ginkgo biloba supplement Inflammation

PROJECT MANAGEMENT:RECENT DEVELOPMENTS AND RESEARCH OPPORTUNITIES

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Journal of Systems Science and Systems Engineering 2012年第2期21卷 129-143页

作者： nicholas G.HALL Department of Management Sciences Fisher College of Business The Ohio State UniversityUSA

This paper studies the business process known as project management. This process has exhibited a remarkable growth in business interest over the last 15 years, as demonstrated by a 1000% increase in membership in the Project Management Institute since 1996. This growth is largely attributable to the emergence of many new diverse business applications that can be successfully managed as projects. The new applications for project management include IT implementations, research and development, new product and service development, corporate change management, and software development. The characteristics of modem projects are typically very different from those of traditional projects such as construction and engineering, which necessitates the development of new project management techniques. We discuss these recent practical developments. The history of project management methodology is reviewed, from CPM and PERT to the influential modem directions of critical chain project management and agile methods. We identify one important application area for future methodological change as new product and service development. A list of specific research topics within project management is discussed. The conclusions suggest the existence of significant research opportunities within project management.

关键词： Project management overview recent practical developments opportunities for research

The formation of massif anorthosite:Petrology in reverse

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Geoscience Frontiers 2013年第2期4卷 195-198页

作者： nicholas Arndt ISTerre Universite Joseph Fourier:UMR5275CNRS1381 rue de la Piscine38400 St Martin d'HeresFrance

Massif anorthosites form when basaltic magma differentiates in crustal magma chambers to form lowdensity plagioclase and a residual liquid whose density was greater than that of enclosing crustal rocks. The plagioclase and minor pyroxene crystallized in-situ on the floor of the magma chamber to produce the anorthosite complex,and the residual liquid migrated downwards,eventually to solidify as dense Fe-rich cumulates some of which were removed to the *** movements were facilitated by high temperatures in Proterozoic continental crust,thus explaining the restriction of large anorthosite massifs to this period in Earth history.

关键词： Anorthosite Petrology Proterozoic

Composites with high omnidirectional fracture toughness due to helical interlocking fasteners are found in gingko seed shells

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National Science Review 2023年第5期10卷 106-108页

作者： nicholas A.Kotov Department of Chemical Engineering Biointerfaces InstituteDepartment of Materials Science and EngineeringUniversity of Michigan Department of Aeronautics Imperial College London

Engineering of composites mimicking load-bearing materials from living organisms is essential for sustainable economic development and successful resolution of current and future bottle-necks of chemical,automotive,av... 详细信息

关键词： POLYELECTROLYTE COMPOSITES

马来西亚东北部Setiu潟湖1970年以来沉积环境演化及其对ENSO的响应

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海洋学报 2024年第4期46卷 79-89页

作者：赵周平李超骆正骅 nicholasNg Chia Wei 戴璐同济大学海洋地质国家重点实验室上海200092

马来半岛位于低纬热带地区,厄尔尼诺-南方涛动(El Nino-Southern Oscillation,ENSO)如何影响该区域的气候,尤其是降水仍然存在争议。本文以马来半岛东北部登嘉楼州Setiu潟湖钻孔NTT-3为研究对象,通过分析粒度、总有机碳及总氮含量、C/N... 详细信息

马来半岛位于低纬热带地区,厄尔尼诺-南方涛动(El Nino-Southern Oscillation,ENSO)如何影响该区域的气候,尤其是降水仍然存在争议。本文以马来半岛东北部登嘉楼州Setiu潟湖钻孔NTT-3为研究对象,通过分析粒度、总有机碳及总氮含量、C/N比值和XRF岩心扫描等,探讨该钻孔的沉积环境变化及其对ENSO的响应。研究结果显示,钻孔记录中自1970年前后(84 cm处)出现两种不同的变化趋势。1970年之前钻孔下部沉积物粒度、有机和无机地球化学特征趋势波动明显,沉积速率较低。而1970年以来,潟湖沉积环境总体稳定,沉积物中的有机组分主要来自红树林,同时伴有河流输入的淡水浮游植物的贡献。频谱分析结果显示1970年以来钻孔上部存在明显的ENSO周期变化。强厄尔尼诺现象基本对应低Zr/Rb比值和低Zr/Ti比值,而强拉尼娜(La Nina)现象基本对应高Zr/Rb比值和高Zr/Ti比值。该结论不仅支持了现代观测对马来半岛东部沿海地区气候变化的认识,同时也在地质记录中发现了ENSO变化的直接证据,对全面认识和理解ENSO对亚洲气候变化的影响、区域陆海相互作用过程和环境响应等方面具有重要现实意义。

关键词： Setiu潟湖沉积记录频谱分析 ENSO

Longitudinal bicyclist,driver,and pedestrian perceptions of autonomous vehicle communication strategies

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第1期10卷 31-44页

作者： nicholas N.Ferenchak Department of Civil Construction&Environmental EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA

We sought to better understand how autonomous vehicle(AV)communication strategies impact human road users’*** specifically,we explored the impact of different external human-machine interface(eHMI)designs on task load,comfort,trust,and *** accomplish this,we created virtual reality(VR)scenarios where human participants interacted with AVs in biking,driving,and pedestrian *** were brought back after initial testing to explore acclimation and learning *** designs included a text-based grille eHMI,a text-based roof eHMI,a text-based driver-side door eHMI,anon-textual LED windshield strip eHMI,and a non-textual side mirror arrow *** presence of an eHMI was the strongest positive predictor of comfort,trust,and acceptance outcomes in the statistical models when controlling for all other *** was a clear divide between text-based eHMIs and non-text eHMIs with text-based eHMIs experiencing better perception *** LED Windshield experienced the worst perception *** were perception acclimation effects detected which were most notable for task load(which decreased over time)and comfort(which increased over time).Perception scores for the different eHMI designs tended to cluster over ***,the acclimation effects had less of an impact than the presence of an *** outcomes had weaker relationships with participant characteristics than with AV *** suggest that eHMI presence and design,AV behavior,and acclimation are most impactful in terms of perceptions.

关键词： Vehicle automation Communication Human-automation interaction Technology acceptance Virtual reality

Nonlinear Model of Mean Free Surface of Waves

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China Ocean Engineering 1999年第2期14卷 155-162页

作者： nicholas DODD Ph. D. Coastal Group HR Wallingford Howbery Park Wallingford

A nonlinear model of mean free surface of waves or wave set-up is presented. The model is based on that of Roelvink (1993), but the numerical techniques used in the solution are based on the Weighted-Average Flux (WAF) method (Watson el al., 1992), with Time-Operator-Splitting (TOS) used for the treatment of the source terms. This method allows a small number of computational points to be used, and is particularly efficient in modeling wave set-up. The short wave (or primary wave) energy equation is solved by use of a more traditional Lax-Wendroff technique. A nonlinear wave theory (James, 1974) is introduced. The model described in this paper is found to be satisfactory in most respects when compared with the measurements conducted by Stive (1983) except in modeling the mean free surface very close to the mean shoreline.

关键词： mean free surface radiation stress hyperbolic wave theory nonlinear model wave propagation

Do neuronal microvascular activation and resultant dysfunction in rheumatoid arthritis contribute to chronic pain?

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Neural Regeneration Research 2019年第1期14卷 79-81页

作者： nicholas Beazley-Long Arthritis Research UK Pain Centre & School of Life Sciences Medical School University of Nottingham

Microvascular dysfunction and rheumatoid arthritis(RA):Across the UK severe osteoarthritis affects～5–7%and RA affects～1%of the *** are the most common causes of disabling chronic pain and are major burdens on individuals and ***,the annual financial cost to the UK economy for arthritis is in the billions of *** living with painful inflammatory conditions and

关键词：风湿性关节炎机能障碍疼痛激活骨关节炎心血管糖尿病 RA