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Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yamixa Delgado Caliani Gaytan naydi perez Eric Miranda Bryan Colón Morales Mónica Santos Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Department of Internal Medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a compelling need to investigate the intricate interplay among body mass index(BMI),pregesta-tional,and gestational maternal diabetes,and their potential impact on the occurrence of congenital heart defects(CHD)during neonatal ***:Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessment encompassed a range of variables,including maternal age,gestational age,BMI,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average maternal age was 26 years,within a range of 22 to 32 *** mean gestational age measured 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mothers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,compared to 200 without;and 148 cases exhibited an overweight or obese BMI,whereas 126 displayed a normal ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes mellitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between maternal BMI and the likelihood of *** results may aid in developing effective strategies to prevent and manage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty maternal health diabetes body mass index(BMI)

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L^1→L^q Poincare Inequalities for 0

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Acta Mathematica Sinica,English Series 2002年第1期18卷 1-20页

作者： perez Carlos Departamento dr Matematicas. Universidad Autónoma de Madrid. 28049 Madrid. Spain

Civen two doubling measures μ and v in a metric apace (S.p)of homogeneous type. let B_0 S be a given ball. It has been a well-known result bv now (see)[1 4])theat the validity of an L^1→L^1 Poincaré inequality of the following form: f_B|f-f_B|dv≤cr(B)f_Bgdμ. for all metric balls B B_0 S, implies a variant of representation formula of fractonal integral type: |f(x)-f_(B(11))|≤C integral from n=B_(11) g(y)p(x, y)/μ(B(x, p(x, y)))dμ(y)+C(r(B_0))/(μ(B_0))integral from n=B_0 g(y)dμ(y). One of the main results of this paper shows that an L^1 to L^q Poincaré inequality for some 01, i.e.. (f_B|f-f_B|~q dv)^(1/q)≤cr(B) f_B gdμ, for all metric balls B B_0. will suffice to imply the above representation formula. As an immediate corollary, we can show that the weak-type condition. sup_(λ>0)(λv({x ∈ B:|f(x)-f_B|>λ}))/v(B)≤Gr (B)f_B gdμ. also implies the same formula. Analogous theorems related to high-order Poincaréinequalities and Sobolev spaces in metric spaces are also proved.

关键词： Sobolev spaces Representation formulas High-order derivatives Vector fields Metric spaces Polynomials Doubling measures Poincare inequalities

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Role of dup A in virulence of Helicobacter pylori

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World Journal of Gastroenterology 2016年第46期22卷 10118-10123页

作者： Amin Talebi Bezmin Abadi Guillermo perez-perez Department of Bacteriology Faculty of Medical Sciences Tarbiat Modares University Departments of Medicine and Microbiology New York University School of Medicine and VA Medical Center

Helicobacter pylori(H. pylori) is a gastric human pathogen associated with acute and chronic gastritis, 70% of all gastric ulcers, 85% of all duodenal ulcers, and both forms of stomach cancer, mucosal-associated lymphoid tissue(MALT) lymphoma and adenocarcinoma. Recently, attention has focused on possible relationship between presence of certain virulence factor and H. pylori-associated diseases. Some contradictory data between this bacterium and related disorders has been observed since not all the colonized individuals develop to severe disease. The reported diseases plausibility related to H. pylori specific virulence factors became an interesting story about this organism. Although a number of putative virulence factors have been identified including cytotoxin-associated gene a(cag A) and vac A, there are conflicting data about their actual participation as specific risk factor for H. pylori-related diseases. Duodenal ulcer promoting gene a(dup A) is a virulence factor of H. pylori that is highly associated with duodenal ulcer development and reduced risk of gastric cancer. The prevalence of dup A in H. pylori strains isolated from western countries is relatively higher than in H. pylori strains from Asian countries. Current confusing epidemiological reports will continue unless future sophisticated and molecular studies provide data on functional and complete dup A cluster in H. pylori infected individuals. This paper elucidates available knowledge concerning role of dup A in virulence of H. pylori after a decade of its discovery.

关键词： Helicobacter pylori dup A Bacterial virulence infection Clinical outcome

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The Finite-dimensional Decomposition Property in Non-Archimedean Banach Spaces

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1833-1845页

作者： Albert KUBZDELA Cristina perez-GARCIA Institute of Civil Engineering Poznań University of TechnologyUl.Piotrowo 561-138 PoznańPoland Department of Mathematics Facultad de CienciasUniversidad de CantabriaAvda.de los Castros s/n39071SantanderSpain

A non-Archimedean Banach space has the orthogonal finite-dimensional decomposition property（OFDDP） if it is the orthogonal direct sum of a sequence of finite-dimensional *** property has an influence in the non-Archimedean Grothendieck＇s approximation theory,where an open problem is the following： Let E be a non-Archimedean Banach space of countable type with the OFDDP and let D be a closed subspace of *** D have the OFDDP？ In this paper we give a negative answer to this question; we construct a Banach space of countable type with the OFDDP having a one-codimensional subspace without the *** we prove that,however,for certain classes of Banach spaces of countable type,the OFDDP is preserved by taking finite-codimensional subspaces.

关键词： Non-Archimedean Banach spaces finite-dimensional decomposition property orthogonal base

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Implementing a vector surveillanceresponse system for chagas disease control:a 4-year field trial in Nicaragua

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Infectious Diseases of Poverty 2017年第1期6卷 154-165页

作者： Kota Yoshioka Doribel Tercero Byron perez Jiro Nakamura Lenin perez Doctor of Public Health Program Harvard T.H.Chan School of Public HealthBostonUSA School of Tropical Medicine and Global Health Nagasaki UniversityNagasakiJapan Former Chagas Disease Control Project Japan International Cooperation AgencyManaguaNicaragua Department of Disease Prevention Ministry of Health in NicaraguaManaguaNicaragua

Background:Chagas disease is one of the neglected tropical diseases(NTDs).International goals for its control involve elimination of vector-borne *** American countries face challenges in establishing sustainable vector control programmes,since the main vector,Triatoma dimidiata,cannot be *** 2012,the Ministry of Health in Nicaragua started a field test of a vector surveillance-response system to control domestic vector *** paper reports the main findings from this pilot ***:This study was carried out from 2012 to 2015 in the Municipality of *** Japan International Cooperation Agency provided technical cooperation in designing and monitoring the surveillance-response system until *** system involved 1)vector reports by householders to health facilities,2)data analysis and planning of responses at the municipal health centre and 3)house visits or insecticide spraying by health personnel as a *** registered all vector reports and responses in a digital *** collected data were used to describe and analyse the system performance in terms of amount of vector reports as well as rates and timeliness of ***:During the study period,*** was reported 396 *** analysis identified some high-risk *** houses reported to be infested were visited by health personnel in 2013 and this response rate dropped to 39%in *** of insecticide spraying rose above 80%in 2013 but no spraying was carried out in the following 2 *** timeliness of house visits improved significantly after the responsibility was transferred from a vector control technician to primary health care ***:We argue that the proposed vector surveillance-response system is workable within the resourceconstrained health system in *** to the primary health care services was a key to improve the system *** efforts are necessary to keep adap

关键词： Chagas disease Triatoma dimidiata Vector control Surveillance-response system Programme integration Nicaragua

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In vitro germination and shoot proliferation of the threatened species Cinchona officinalis L(Rubiaceae).

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Journal of Forestry Research 2016年第6期27卷 1229-1236页

作者： Rosa Armijos-Gonzalez Cesar perez-Ruiz Departamento de Ciencias Naturales Universidad Tecnica Particular de LojaCP 1101 608 LojaEcuador Departamento de Biotecnologia y Biologia Vegetal E.T.S.Ingenieros AgronomosUniversidad Politecnica de MadridCP 728040 MadridSpain

Cinchona officinalis （Rubiaceae） is an endemic species of the Loja Valley in southern Ecuador with medicinal uses. Because of over-exploitation in the nine- teenth century and more recent disturbances to its ecosystem, C. officinalis populations are threatened. Currently, natural regeneration of the populations is low, despite its high plant regeneration and seed formation capacity. In the present study, an efficient protocol for germination, shoot proliferation and plantlets regeneration was developed for this species. Phenolic content and germination rate of C. officinalis seeds were compared with a control species, C. pubescens. Nodal segments from seedlings of C. officinalis were cultured on Gamborg medium supplemented with different combinations of plant growth regulators. Because the phenol content is high in C. officinalis, the phenolic should be removed with hydrogen peroxide or water washes to stimulate germination. Shoots and callus developed from nodal segments within 45 days using most of the tested combinations of plant growth regulators. The best rates of shoot proliferation, callus formation and adventitious buds were obtained in medium supplemented with 5.0 mg L^-1 6-benzyl-aminopurine and 3.0 mg L^-1 indole- 3-butyfic acid.

关键词： Callus Cinchona officinalis Germination Phenols Rubiaceae Shoot

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Effect of grain recrystallization on stir zone and mechanical property behavior of TRIP 780 steel

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Journal of Iron and Steel Research International 2020年第2期27卷 188-196页

作者： Gladys perez-Medina Hugo Lopez Argelia Miranda-perez Eduardo Hurtado-Delgado Postgraduate Studies Mexican Corporation in Materials ResearchSaltillo Coahuila 25290Mexico Materials Department University of Wisconsin-MilwaukeeMilwaukeeWI 53201USA

Electron backscatter diffraction(EBSD)and transmission electron microscopy were used to determine the presence of retained austenite and displacive-type phase transformation in the stir zone of friction stir welding(FSW).Severe plastic deformations occurred in the stir zone where there was an increase in the temperature attributed to the FSW process and subsequently a grain *** the recrystallization phenomena,the formation of grain evolution development in steels was resolved using *** addition,a tensile test was carried out in order to reveal the results of mechanical *** was found that the fracture zone occurred in the stir zone with an ultimate tensile strength of 587 MPa,a decrease of 267 MPa compared with that of the base *** this result,it is evident that the fracture exhibits numerous elongated dimples,distributed homogeneously,and certain locations contain cleavage fractures due to differences in the microstructure of the base *** profile tests of the welding regions were conducted,and the results showed that the stir zone was present with elevated hardness(near 350 HV).Characterization techniques revealed that the austenite-to-martensite transformation occurred in the stir zone,resulting in a loss of mechanical properties in the joint.

关键词： Friction welding Transformation-induced plasticity steel Stir zone Mechanical property Tensile test

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Synthesis of hydroxymethylfurfural and furfural from hardwood and softwood pulp using ferric sulphate as catalyst

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 531-542页

作者： Agneev Mukherjee Guillermo Portillo-perez Marie-Josee Dumont Bioresource Engineering Department McGill UniversityQC H9X 3V9Canada

Hydroxymethylfurfural (HMF) and furfural are promising chemicals for the creation of a bio-based economy. The development of an inexpensive catalytic system for converting cellulosic biomass into these chemicals is an important step in this regard. Ferric sulphate is a common, cheap and non-toxic Lewis acid that has been used to catalyse reactions such as wood depolymerisation. In this work, ferric sulphate was used to help the production of HMF and furfural from hardwood and softwood pulps. It was found that for hardwood pulp, the use of ferric sulphate alone gave a maximum HMF yield of 31.6 mol-%. The addition of the ionic liquid [BMIM]Cl or HCl as co-catalysts did not lead to an increase in the yields obtained. A prior decationisation step, however, resulted in HMF yields of 50.4 mol-%. Softwood pulp was harder to depolymerise than hardwood, with a yield of 28.7% obtained using ferric sulphate alone. The maximum HMF yield from softwood, 37.9 mol-%, was obtained using a combination of ferric sulphate and dilute HCl. It was thus concluded that ferric sulphate is a promising catalyst for HMF synthesis from cellulosic biomass.

关键词： 5-hydroxymethylftirfural hardwood softwood ferric sulphate biorefinery

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Automated calculation and convergence of defect transport tensors

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npj Computational Materials 2020年第1期6卷 89-95页

作者： Thomas D.Swinburne Danny perez Aix-Marseille Université CNRSCINaM UMR 7325Campus de LuminyMarseille 13288France Theoretical Division T-1 Los Alamos National LaboratoryLos AlamosNM 87545USA

Defect diffusion is a key process in materials science and catalysis,but as migration mechanisms are often too complex to enumerate a priori,calculation of transport tensors typically have no measure of convergence and require significant end-user *** two bottlenecks prevent high-throughput implementations essential to propagate model-form uncertainty from interatomic interactions to predictive *** order to address these issues,we extend a massively parallel accelerated sampling scheme,autonomously controlled by Bayesian estimators of statewide sampling completeness,to build atomistic kinetic Monte Carlo models on a state-space irreducible under exchange and space group *** on isolated defects,we derive analytic expressions for drift and diffusion coefficients,providing a convergence metric by calculating the Kullback–Leibler divergence across the ensemble of diffusion processes consistent with the sampling *** autonomy and efficacy of the method is demonstrated on surface trimers in tungsten and Hexa-interstitials in magnesium oxide,both of which exhibit complex,correlated migration mechanisms.

关键词： convergence diffusion calculation

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Integration and implementation of precision medicine in the multifaceted inflammatory bowel disease

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World Journal of Gastroenterology 2023年第36期29卷 5211-5225页

作者： Gowthami Sai Kogilathota Jagirdhar Jose Andres perez Andrea Belen perez Salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Medicine Saint Francis Health SystemsTulsaOK 74133United States Department of Research Columbia UniversityNew YorkNY 10027United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77413United States

Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and *** medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of *** medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic *** is a recent and rapidly developing *** widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with *** precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing *** is discordance in study conduct,and data collection,utilization,interpretation,and *** review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.

关键词： Precision medicine Multiomics Inflammatory bowel disease Crohn’s disease Ulcerative colitis Data integration

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