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Time trend and seasonality in medically attended respiratory syncytial virus (RSV) infections in US children aged 0-5 years, January 2010-January 2023

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Family Medicine and Community Health 2023年第4期11卷 36-44页

作者： Lindsey wang nathan berger Pamela b Davis David C Kaelber Nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for Artificial Intelligence in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective The long-term time trend and seasonality variations of first-time medically attended respiratory syncytial virus(RSV)infections among young children are *** aim to examine the time trend of medically attended first-time RSV infections among young children in the USA from January 2010 through January *** This is a population-based cohort study using electronic health records(EHRs).Monthly incidence rate of medically attended first-time RSV infection(cases per 10000000 person-days).A time-series regression model was used to model and predict time trends and *** Multicenter and nationwide TriNetX Network in the *** The study population comprised children aged 0–5 years who had medical visits during the period of January 2010 to January *** The data included 29013937 medical visits for children aged 0–5 years(46.5%girls and 53.5%boys)from January 2010 through January *** 2010 through 2019,the monthly incidence rate of first-time medically attended RSV infection in children aged 0–5 years followed a consistent seasonal *** patterns of medically attended RSV infections were significantly disrupted during the COVID-19 *** 2020,the seasonal variation disappeared with a peak incidence rate of 20 cases per 1000000 person-days,a decrease of 97.4%from the expected peak rate(rate ratio or RR:0.026,95%CI 0.017 to 0.040).In 2021,the seasonality returned but started 4 months earlier,lasted for 9 months,and peaked in August at a rate of 753 cases per 1000000 person-days,a decrease of 9.6%from the expected peak rate(RR:0.90,95%CI 0.82 to 0.99).In 2022,the seasonal pattern is similar to prepandemic years but reached a historically high rate of 2182 cases per 10000000 person-days in November,an increase of 143%from the expected peak rate(RR:2.43,95%CI 2.25 to 2.63).The time trend and seasonality of the EHR-based medically attended RSV infections are consistent with those of RSV-associated hospital

关键词： infections trend attended

Association of COVID- 19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study

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Family Medicine and Community Health 2023年第4期11卷 45-55页

作者： Lindsey wang Pamela b Davis nathan berger David C Kaelber Nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for AI in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective To investigate whether COVID-19 infection was associated with increased risk for incident respiratory syncytial virus(RSV)infections and associated diseases among young children that might have contributed to the 2022 surge of severe paediatric RSV cases in the *** This is a retrospective population-based cohort *** outcomes were examined,including overall RSV infection,positive lab test-confirmed RSV infection,clinically diagnosed RSV diseases,RSV-associated bronchiolitis and unspecified *** ratio(RR)and 95%CI of the outcomes that occurred during the 2022 and 2021 RSV seasons were calculated by comparing propensity-score matched *** Nationwide multicentre database of electronic health records(EHRs)of 61.4million patients in the USA including 1.7million children 0–5 years of age,which was accessed through TriNetX Analytics that provides web-based and secure access to patient EHR data from hospitals,primary care and specialty treatment *** The study population consisted of 228940 children of 0–5 years with no prior RSV infection who had medical encounters in October *** were replicated in a separate study population of 370919 children of 0–5 years with no prior RSV infection who had medical encounters in July 2021–August 2021 during a non-overlapping time *** For the 2022 study population(average age 2.4 years,46.8%girls,61%white,16%black),the risk for incident RSV infection during October 2022–December 2022 was 6.40%for children with prior COVID-19 infection,higher than 4.30%for the matched children without COVID-19(RR 1.40,95%CI 1.27 to 1.55);and among children aged 0–1year,the overall risk was 7.90%for those with prior COVID-19 infection,higher than 5.64%for matched children without(RR 1.40,95%CI 1.21 to 1.62).For the 2021 study population(average age 2.2 years,46%girls,57%white,20%black),the risk for incident RSV infection during July 2021–December 2021 was 4.85%for childre

关键词： infections matched centre

Data-driven models for ground and excited states for Single Atoms on Ceria

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npj Computational Materials 2022年第1期8卷 1636-1643页

作者： Julian Geiger Albert Sabadell-Rendón nathan Daelman Núria López Institute of Chemical Research of Catalonia(ICIQ) The Barcelona Institute of Science and Technology(BIST)Avinguda Països Catalans 1643007TarragonaSpain Universitat Rovira i Virgili Avinguda Catalunya3543002TarragonaSpain

Ceria-based single-atom catalysts present complex electronic structures due to the dynamic electron transfer between the metal atoms and the semiconductor oxide *** these materials implies retrieving all states in these electronic ensembles,which can be limiting if done via density functional ***,we propose a data-driven approach to obtain a parsimonious model identifying the appearance of dynamic charge transfer for the single atoms(SAs).we first constructed a database of(701)electronic configurations for the group 9–11 metals on CeO_(2)(100).Feature Selection based on predictive Elastic Net and Random Forest models highlights eight fundamental variables:atomic number,ionization potential,size,and metal coordination,metal–oxygen bond strengths,surface strain,and Coulomb *** these variables a bayesian algorithm yields an expression for the adsorption energies of SAs in ground and low-lying excited *** work paves the way towards understanding electronic structure complexity in metal/oxide interfaces.

关键词： theory excited states

nuMap: A web Platform for Accurate Prediction of Nucleosome Positioning

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Genomics, Proteomics & bioinformatics 2014年第5期12卷 249-253页

作者： bader A.Alharbi Thamir H.Alshammari nathan L.Felton Victor b.Zhurkin Feng Cui Thomas H. Gosnell School of Life Sciences Rochester Institute of Technology b. Thomas Golisano College of Computing & Information Sciences Rochester Institute of Technology Information Technology Services Rochester Institute of Technology Laboratory of Cell biology National Cancer Institute National Institutes of Health

Nucleosome positioning is critical for gene expression and of major biological interest. The high cost of experimentally mapping nucleosomal arrangement signifies the need for computational approaches to predict nucleosome positions at high resolution. Here, we present a web-based application to fulfill this need by implementing two models, YR and w/S schemes, for the translational and rotational positioning of nucleosomes, respectively. Our methods are based on sequence-dependent anisotropic bending that dictates how DNA is wrapped around a histone octamer. This application allows users to specify a number of options such as schemes and param- eters for threading calculation and provides multiple layout formats. The nuMap is implemented in Java/Perl/MySQL and is freely available for public use at http：//***. The user manual, implementation notes, description of the methodology and examples are available at the site.

关键词： Nucleosome rotational posi-tioning Sequence-dependent DNAanisotropy Prediction of nucteosomepositioning Sequence patterns web server

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Effect of power-law nonlinearity on PT-symmetric optical system with fourth-order diffraction

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Communications in Theoretical Physics 2020年第5期72卷 32-40页

作者： nathan N Tchepemen Camus G L Tiofack Alidou Mohamadou Pure Physics Laboratory Group of Nonlinear Physics and Complex SystemsDepartment of PhysicsFaculty of scienceUniversity of DoualaPO Box 24157DoualaCameroon Condensed Matter Laboratory Department of PhysicsFaculty of ScienceUniversity of MarouaPO Box 814MarouaCameroon Centre d'Excellence Africain des Technologies de l'Information et de la Communication(CETIC) University of Yaounde ICameroon The Abdus Salam International Centre for Theoretical Physics PO Box 538Strada costiera 11I-34014TriesteItaly

Gaussian-type soliton solutions of the nonlinear Schr?dinger(NLS)equation with fourth order dispersion,and power law nonlinearity in the novel parity-time(TP)-symmetric quartic Gaussian potential are derived analytically and *** exact analytical expressions of the solutions are obtained in the first two-dimensional(1D and 2D)power law NLS *** means of the linear stability analysis,the effect of power law nonlinearity on the stability of Gauss type solitons in different nonlinear media is carried *** investigations do confirm the stability of our soliton solutions in both focusing and defocusing cases,specially around the propagation parameters.

关键词： TP-symmetric quartic Gaussian potential fourth-order diffraction powerlaw nonlinearity stability Gaussian soliton

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Neonatal pneumothorax in congenital diaphragmatic hernia:be wary of high ventilatory pressures

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world Journal of Pediatric Surgery 2022年第3期5卷 154-161页

作者： nathan Rubalcava Gabriella A Norwitz Aimee G Kim Gary weiner Niki Matusko Meghan A Arnold George b Mychaliska Erin E Perrone Pediatric Surgery University of MichiganAnn ArborMichiganUSA Section of Neonatology Department of PediatricsUniversity of MichiganAnn ArborMichiganUSA Department of Surgery University of MichiganAnn ArborMichiganUSA

background Patients with congenital diaphragmatic hernia(CDH)require invasive respiratory support and higher ventilator pressures may be associated with *** sought to evaluate the risk factors associated with pneumothorax in CDH neonates prior to *** weretrospectivelyreviewednewborns born withCDHbetween 2014and 2019who developeda pneumothorax,and we matched these cases to patients with CDH without *** Twenty-sixpatientswere included(n=13per group).The pneumothorax group required extracorporeal life support(ECLS)more frequently(85%vs 54%,p=0.04),particularly among type A/b defects(31%vs 7%,p=0.01).The pneumothorax group had higher positive end-expiratory pressure(PEEP)within 1 hour of birth(p=0.02),at pneumothorax diagnosis(p=0.003),and at ECLS(p=0.02).The pneumothorax group had a higher mean airway pressure(Paw)at birth(p=0.01),within 1 hour of birth(p=0.01),and at pneumothorax diagnosis(p=0.04).Using multiple logistic regression with cluster robust SEs,higher Paw(OR 2.2,95%Cl 1.08 to 3.72,p=0.03)and PEEP(OR 1.8,95%CI 1.15 to 3.14,p=0.007)were associated with an increased risk of developing *** was no difference in survival(p=0.09).Conclusions Development of a pneumothorax in CDH neonates is independently associated with higher Paw and higher PEEP.A pneumothorax increases the likelihood of treated with ECLS,even with smaller defect.

关键词： PEEP pneumothorax diagnosis

Mean and fluctuating velocity fields of a diamond turbulent jet

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Chinese Physics b 2013年第3期22卷 344-351页

作者：徐敏义张健鹏米建春 nathan G.J. Kalt P.A.M. State Key Laboratory of Turbulence & Complex Systems College of EngineeringPeking University Marine Engineering College Dalian Maritime University Centre for Energy Technology and School of Mechanical Engineering University of AdelaideSA 5005Australia

The present paper reports the first investigation on a turbulent jet issuing from a diamond orifice（hereafter termed a ＂diamond jet＂） with an aspect ratio of *** measurements were conducted in the transitional region,and the exit Reynolds number of the jet was *** comparison,a round jet with identical normalized boundary conditions was also *** is shown that the diamond jet decays and spreads faster than the round jet does over the measured flow *** axis-switching phenomenon is observed in the diamond *** both jets display primary coherent structures in the near field,these structures are found to break down more rapidly in the diamond jet,due to the higher three-dimensionality of the ***,the streamwise components of the Reynolds normal stress and all the shear stresses reach their maxima around the location of the maximal mean shear while the maxima of the lateral components of the Reynolds normal stresses occur around the centreline of the jet.

关键词： turbulent jet non-circular jet PIV measurement jet entrainment

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Recent developments on Opuntia spp.,their bioactive composition,nutritional values,and health effects

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Food bioscience 2022年第3期47卷 46-66页

作者： Davor Daniloski nathan M.D'Cunha Hollie Speer Andrew J.McKune Natalie Alexopoulos Demosthenes b.Panagiotakos Anka T.Petkoska Nenad Naumovski Victoria University Advanced Food Systems Research UnitInstitute for Sustainable Industries and Liveable Cities and College of Health and BiomedicineMelbourneVictoria8001Australia Teagasc Food Research Centre Food Chemistry and Technology DepartmentMooreparkFermoyP61 C996CorkIreland University of Canberra Faculty of HealthSchool of Rehabilitation and Exercise SciencesBruceAustralian Capital Territory2617Australia University of Canberra Functional Foods and Nutrition Research (FFNR) LaboratoryNgunnawal CountryBruceAustralian Capital Territory2617Australia University of Canberra Research Institute for Sport and Exercise (UC-RISE)BruceAustralian Capital Territory2617Australia University of KwaZulu-Natal Discipline of BiokineticsExercise and Leisure SciencesSchool of Health ScienceDurbanKwaZulu-Natal4000South Africa Chiron Organic Health WedderburnVictoria3518Australia Harokopio University Discipline of Nutrition and DieteticsSchool of Health Science and EducationAthens17676Greece St.Clement of Ohrid University of bitola Faculty of Technology and Technical SciencesDimitar Vlahov4000VelesNorth Macedonia

Opuntia is a plant that grows in wild,arid,and semi-arid regions,and it is a renowned food source that is presently *** chemical composition and properties of the Opuntia genus have attracted research and commercial interest as its species are rich in phytochemicals,nutrients,and bioactive *** of these constituents have revealed anti-inflammatory,antioxidant,antibacterial,anti-cancer,anti-atherosclerotic,antidiabetic,neurological,and gut protective *** review provides an extensive and up-to-date evidence synthesis of the nutrients in the Opuntia genus,its phytochemical composition,health benefits,the influence of the processing technologies on its bioactive components,and the potential for functional food product *** to its high nutritional value,Opuntia genus has the potential to contribute to improving food security and contribute to the food industry as food additive or ***,Opuntia products can be utilized as food substitutes as part of a well-balanced diet and may potentially have pharmacological *** Opuntia genus is also used as animal feed,a source of nutraceuticals,an addition to edible packaging materials,wastewater treatment,and land rehabilitation in arid *** is a rich source of minerals,essential amino acids,and vitamins,and is high in antioxidants,making it a promising candidate for the management of non-communicable *** potential health-promoting effects of Opuntia consumption remain relatively unexplored,and further research human trials are required to unravel its mechanisms of action.

关键词： Opuntia Functional food bioactive compounds Non-communicable diseases Health benefits

Reduced Cataplexy Symptoms while on Suboxone: A Case Report

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Journal of behavioral and brain Science 2022年第11期12卷 548-551页

作者： nathan b. Omari Ngugi M. Kinyungu University of Houston-Downtown Houston USA ITAV Pain Management Donald and Barbara Zucker School of Medicine at Hofstra/Northwell New York USA

background: Narcolepsy type 1 is a sleep disorder characterized by excessive sleepiness along with cataplexy and/or hypocretin deficiency. we present a case of narcolepsy type 1 in which the cataplexy symptoms were reduced while on suboxone. Aim: This case report aims to note the reduction of cataplexy symptoms with suboxone. Case Presentation: A 39-year-old female patient with narcolepsy type 1 was referred to our pain clinic for management with suboxone. The patient had tried various other medications for the management of narcolepsy. with opioid management, the patient reported reduced cataplexy symptoms. Conclusion: The case illustrates the scientific thought that opioids could increase hypocretin and reduce symptoms in narcolepsy type 1.

关键词： Narcolepsy Cataplexy Suboxone Sleep Muscle Tone