Association of COVID- 19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study
作者机构：Center for ScienceHealthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health IntegrationCase Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal MedicinePediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug AbuseNational Institute of HealthBethesdaMarylandUSA Center for AI in Drug DiscoveryCase Western Reserve University School of MedicineClevelandOhioUSA
出 版 物：《Family Medicine and Community Health》 (家庭医学与社区卫生（英文）)
年 卷 期：2023年第11卷第4期
页 面：45-55页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：support from the National Institute on Aging(grants nos.AG057557,AG061388,AG062272,AG07664) National Institute on Alcohol Abuse and Alcoholism(grant no.AA029831) National Cancer Institute Case Comprehensive Cancer Center(CA221718,CA043703)
主 题：infections matched centre
摘 要：Objective To investigate whether COVID-19 infection was associated with increased risk for incident respiratory syncytial virus(RSV)infections and associated diseases among young children that might have contributed to the 2022 surge of severe paediatric RSV cases in the *** This is a retrospective population-based cohort *** outcomes were examined,including overall RSV infection,positive lab test-confirmed RSV infection,clinically diagnosed RSV diseases,RSV-associated bronchiolitis and unspecified *** ratio(RR)and 95%CI of the outcomes that occurred during the 2022 and 2021 RSV seasons were calculated by comparing propensity-score matched *** Nationwide multicentre database of electronic health records(EHRs)of 61.4million patients in the USA including 1.7million children 0–5 years of age,which was accessed through TriNetX Analytics that provides web-based and secure access to patient EHR data from hospitals,primary care and specialty treatment *** The study population consisted of 228940 children of 0–5 years with no prior RSV infection who had medical encounters in October *** were replicated in a separate study population of 370919 children of 0–5 years with no prior RSV infection who had medical encounters in July 2021–August 2021 during a non-overlapping time *** For the 2022 study population(average age 2.4 years,46.8%girls,61%white,16%black),the risk for incident RSV infection during October 2022–December 2022 was 6.40%for children with prior COVID-19 infection,higher than 4.30%for the matched children without COVID-19(RR 1.40,95%CI 1.27 to 1.55);and among children aged 0–1year,the overall risk was 7.90%for those with prior COVID-19 infection,higher than 5.64%for matched children without(RR 1.40,95%CI 1.21 to 1.62).For the 2021 study population(average age 2.2 years,46%girls,57%white,20%black),the risk for incident RSV infection during July 2021–December 2021 was 4.85%for childre
维普期刊数据库