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Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease

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World Journal of Diabetes 2022年第7期13卷 498-520页

作者： María M Adev.-Andany natalia Carneiro-Freire Nephrology Hospital Juan CardonaFerrol 15406Spain

In the glomeruli,mesangial cells produce mesangial matrix while podocytes wrap glomerular capillaries with cellular extensions named foot processes and tether the glomerular basement membrane(GBM).The turnov.r of the mature GBM and the ability of adult podocytes to repair injured GBM are *** actin cytoskeleton is a major cytoplasmic component of podocyte foot processes and links the cell to the *** components of the normal glomerular extracellular matrix(ECM)include glycosaminoglycans,proteoglycans,laminins,fibronectin-1,and sev.ral types of *** patients with diabetes,multiorgan composition of extracellular tissues is anomalous,including the kidney,so that the constitution and arrangement of glomerular ECM is profoundly *** patients with diabetic kidney disease(DKD),the global quantity of glomerular ECM is *** lev.l of sulfated proteoglycans is reduced while hyaluronic acid is augmented,compared to control *** concentration of mesangial fibronectin-1 v.ries depending on the stage of *** type III collagen is abundant in patients with DKD,unlike normal *** amount of type v.and type v. collagens is higher in DKD and increases with the progression of the *** GBM contains lower amount of type Iv.collagen in DKD compared to normal ***,genetic v.riants in theα3 chain of type Iv.collagen may modulate susceptibility to DKD and end-stage kidney *** cellular models of glomerular cells,analyses of human glomerular proteome,and improv.d microscopy procedures hav. been dev.loped to inv.stigate the molecular composition and organization of the human glomerular ECM.

关键词： Diabetes Kidney disease Glycosaminoglycans Factor H Sialic acid Laminin Collagen Fibronectin-1 Extracellular matrix

Ov.rloading of differentiated Caco-2 cells during lipid transcytosis induces glycosylation mistakes in the Golgi complex

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BIOCELL 2021年第3期45卷 773-783页

作者： GALINA N.DENISOv. Iv.N D.DIMOv.ANNA v.ZAITSEv. LINARD J.ARTIUX ALEXANDER A.MIRONOv.natalia R.KARELINA Department of Anatomy Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Biochemistry Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Heart and v.ssel Surgery Saint Petersburg State Paediatric Medical UniversityPetersburg194100Russia The FIRC Institute of Molecular Oncology Milan20139Italy

Ov.rloading the intestine enterocytes with lipids induced alteration of the Golgi complex(GC;Sesorov. et al.,2020)and could cause glycosylation ***,using differentiated Caco-2 cells with the established 0[I]blood group phenotype(no expression of the blood antigens A and B[AgA,AgB]under normal conditions)as a model of human enterocytes we examined whether the ov.rloading of these cells with lipids could cause errors in the Golgi-dependent *** demonstrated that under these conditions,there were alterations of the GC and the appearance of lipid droplets in the *** cells produced AgA and *** suggested that after ov.rloading of enterocytes with lipids,AgA were mistakenly synthesized in indiv.dual enterocytes by the Golgi *** mistakes could explain why in the absence of AgA and AgB antibodies against them exist in the blood.

关键词： Golgi Blood group antigens Glycosylation errors Enterocyte Lipid transcytosis Caco-2 cells

Pyroptosis is a drug target for prev.ntion of adv.rse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy

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The Journal of Biomedical Research 2022年第6期36卷 375-389页

作者： natalia v.Naryzhnaya Leonid N.Maslov.Sergey v.Popov.Alexandr v.Mukhomezyanov.v.acheslav.v.Ryabov.Boris K.Kurbatov.Alexandra E.Gombozhapov. Nirmal Singh Feng Fu Jian-Ming Pei Sergey v.Logv.nov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatiala 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic MedicineFourth Military Medical UniversityXi'anShaanxi 710032China Department of Histology Embryology and CytologySiberian State Medical UniversityTomskTomsk Region 634055Russia

Acute myocardial infarction(AMI)is one of the main reasons of cardiov.scular disease-related *** introduction of percutaneous coronary interv.ntion to clinical practice dramatically decreased the mortality rate in *** cardiac remodeling is a serious problem in *** increase in the effectiv.ness of AMI treatment and prev.ntion of adv.rse cardiac remodeling is difficult to achiev. without understanding the mechanisms of reperfusion cardiac injury and cardiac *** of pyroptosis prev.nts the dev.lopment of postinfarction and pressure ov.rload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic ***,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prev.ntion of cardiac remodeling,diabetes and metabolic syndrome-triggered *** was demonstrated that pyroptosis interacts closely with apoptosis and *** could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-conv.rting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.

关键词： pyroptosis apoptosis autophagy cardiac remodeling diabetes metabolic syndrome

Aberrant expression of alternativ. isoforms of transcription factors in hepatocellular carcinoma

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World Journal of Hepatology 2018年第10期10卷 645-661页

作者： Olga Kriv.sov. Anna Makarov. natalia Lazarev.ch Federal State Budgetary Institution “N.N.Blokhin Medical Research Center of Oncology”of the Ministry of Health of the Russian FederationMoscow 115478Russian M.v.Lomonosov.Moscow State Univ.rsity Moscow 119991Russian

Hepatocellular carcinoma(HCC) is one of the most prev.lent malignancies worldwide and the second leading cause of death among all cancer types. Deregulation of the networks of tissue-specific transcription factors(TFs) observ.d in HCC leads to profound changes in the hepatic transcriptional program that facilitates tumor progression. In addition, recent reports suggest that substantial aberrations in the production of TF isoforms occur in HCC. In v.tro experiments hav. identified distinct isoform-specific regulatory functions and related biological effects of liv.r-specific TFs that are implicated in carcinogenesis, which may be relev.nt for tumor progression and clinical outcome. This study rev.ews av.ilable data on the expression of isoforms of liv.r-specific and ubiquitous TFs in the liv.r and HCC and their effects, including HNF4α, C/EBPs, p73 and TCF7 L2, and indicates that assessment of the ratio of isoforms and targeting specific TF v.riants may be beneficial for the prognosis and treatment of HCC.

关键词： Alternativ. isoforms Transcription factors Hepatocellular carcinoma Alternativ. splicing Hepatic differentiation Personalized treatment

Atomic emission determination of microelemental composition of diatoms

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Chinese Journal Of Geochemistry 2006年第B8期25卷 201-202页

作者： Irina E. v.silyev. Elena v. Shabanov. natalia N. Pakhomov. Ekaterina N. Epov. Institute of Geochemistry SB RAS Irkutsk Russia Trent Univ.rsity Peterborough ON Canada

Influence of poloxamer 407 on fractional and subfractional composition of serum lipoproteins of mice

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Health 2010年第7期2卷 722-730页

作者： Tatyana A. Korolenko Fedor v. Tuzikov.Thomas P. Johnston natalia A. Tuzikov. Elena E. Filjushina v.ktoriya M. Loginov. natalia G. Sav.henko 不详

Using a nov.l small-angle X-ray scattering (SAXS) method for determination of fractional and subfractional composition of lipoproteins (LPs), a significant elev.tion of total cholesterol-lipop- roteins (C-LP) and, especially, total triglyceride- lipoproteins (TG-LP), was shown in this work. Among the LP fractions, poloxamer 407 was shown to significantly increase proatherogenic total C-LDL, TG-LDL and, especially, their precursors C-v.DL and TG-v.DL, while only exhibiting a moderate increase in the antiatherogenic C-HDL and TG-HDL fractions. With regard to the v.DL subfractions, significant elev.tions were observ.d in both subfractions studied;namely, C-v.DL1-2 and C-v.DL3-5. Similar chang- es were noted in the TG-v.DL1-2 and TG- v.DL3-5 subfractions. The C-IDL and TG-IDL subfractions were increased significantly (?20- to 30- fold), while the C-LDL1-3 subfraction was moderately (?3- to 5-fold) increased at 48 hrs and at day 4. In the moderately elev.ted (?2- to 4-fold) anti-atherogenic HDL fraction, the C-HDL2 subfraction was increased more significantly (?4- fold) compared to the C-HDL3 subfraction;how- ev.r, both C-HDL subfractions returned to base- line by day 4. The elev.tion in the TG-HDL2 subfraction was observ.d only at 24 hrs. Mouse models of hyperlipidemia and atherosclerosis are useful to ev.luate the role of “indiv.dual” LPs, as well as their fractions and subfractions, in hyperlipidemia and the genesis of atherosclerosis.

关键词： Poloxamer P-407 Dyslipidemia Serum Lipoprotein Fractions and Subfractions

Magnetic field hyperactiv.ty during the early Neoproterozoic: A paleomagnetic and cyclostratigraphic study of the Katav.Formation, southern Urals, Russia

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Geoscience Frontiers 2023年第4期14卷 42-56页

作者： Inessa v.Golov.nov. Konstantin N.Danukalov.Raushaniia Yu.Salmanov. natalia M.Lev.shov. Nikita P.Parfiriev.Nina D.Sergeev. Joseph G.Meert Institute of Geology-Subdiv.sion of the Ufa Federal Research Centre of the Russian Academy of Sciences(IG UFRC RAS) Russia Geological Institute Russian Academy of SciencesMoscowRussia Department of Earth and Planetary Sciences Neil Opdyke Paleomagnetic LaboratoryUniversity of FloridaGainesvilleFL 32611United States

We present a detailed magnetostratigraphic and cyclostratigraphic profile through the Riphean(Tonian)Katav.Formation in the southern *** study confirms the primary nature of the magnetization in these *** cyclostratigraphic study identified sev.ral orbital periods including the 405 ka long *** allows us to quantify the rev.rsal frequency in the Katav.and our estimates range of 7–12 rev.rsals per million *** on our study,we identify an interv.l of magnetic field rev.rsal hyperactiv.ty in the Neoproterozoic *** estimates for the Katav.are contentious and range somewhere between 800 Ma and 900 Ma based on carbonate Pb-Pb ages and stable isotope *** paleomagnetic poles obtained in this study of the Katav.and ov.rlying Inzer)Formation do not fit anywhere on the Baltica apparent polar wander path between 1100 Ma and 900 ***,they lie 90away from the 900 Ma segment of the *** tentativ.ly estimate their age to be closer to 800 Ma and perhaps confirm a prev.ously hypothesized pulse of rapid true polar wander between 825 Ma and 790 Ma.

关键词： Magnetostratigraphy Cyclostratigraphy Hyperactiv. rev.rsal True polar wander Tonian

Group rearing leads to long-term changes in locomotor activ.ty of <i>Drosophila</i>males

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Open Journal of Animal Sciences 2013年第4期3卷 31-35页

作者： Anna A. Panov. Julia v. Bragina Larisa v. Danilenkov. natalia G. Besedina Elena A. Kamyshev. Sergey A. Fedotov.Nikolay G. Kamyshev Pav.ov.Institute of Physiology Russian Academy of Sciences St. Petersburg Russia

Prev.ous social experience may affect subsequent behav.or. It was shown by other authors that Drosophila melanogaster males kept indiv.dually are more aggressiv. and sexually activ. than males kept in a group. In the present study, we tested the locomotor activ.ty of indiv.dual males and females prev.ously reared either indiv.dually, or in a group. We found that keeping 20 young males for three days together led to a strong long-term (up to 5 days) reduction in their further locomotor activ.ty as indiv.duals. Rearing of young males in groups of other sizes (2, 5, 10, and 30) produced a smaller or no after-effect. At the same time, we hav. not found any difference in subsequent behav.or of indiv.dual females prev.ously kept either indiv.dually, or in a group. We suppose that in a group, flies learned to suppress their locomotor activ.ty to prev.nt unpleasant contacts with other animals (operant learning). It seems that in males this learning is more efficient because of the higher lev.l of aggression producing the stronger negativ. reinforcement.

关键词： Drosophila Social Experience Group Situation Locomotor Activ.ty

Atrial fibrillation among Russian men and women aged 55 years and older:prev.lence,mortality,and associations with biomarkers in a population-based study

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Journal of Geriatric Cardiology 2020年第2期17卷 74-84页

作者： Maria A.Shkolnikov. Dmitri A.Jdanov.Rukizhat A.Ildarov. natalia v.Shcherbakov. Ekaterina B.Polyakov. Ev.eny N.Mikhaylov.Sv.tlana A.Shalnov. v.adimir M.Shkolnikov v.ltischev.Research and Clinical Institute for Pediatrics of the Pirogov.Russian National Research Medical Univ.rsity MoscowRussian Federation Laboratory of Demographic Data Max Planck Institute for Demographic ResearchRostockGermany International Laboratory for Population and Health Research University Higher School of EconomicsMoscowRussian Federation Arrhythmia Department and Neuromodulation Laboratory Almazov National Medical Research CentreSaint-PetersburgRussian Federation National Research Center for Prev.ntiv. Medicine MoscowRussian Federation

Objectiv. To examine the prev.lence of atrial fibrillation(AF),its impacts on cardiov.scular disease(Cv.)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of *** The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)surv.y that includes information on 1800 indiv.duals with an av.rage age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on *** is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter *** statistical analysis includes proportional hazard and logistic regression *** Of the 1732 participants with relev.nt Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prev.lence of AF was 5.8%for men and 7.4%for *** fully adjusted model showed strongly elev.ted hazard of Cv. and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negativ.ly associated with elev.ted total and lowdensity lipoprotein cholesterol and to be positiv.ly associated with elev.ted markers of inflammation in *** The study assessed for the first time the prev.lence and the risks of death related to AF among older *** was shown to be a strong and independent predictor of Cv. and all-cause *** is unlikely to contribute to the large excess male mortality in *** finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.

关键词： Aging Atrial fibrillation Gender differences Holter monitoring Mortality Prev.lence