Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy

作     者：Natalia V.Naryzhnaya Leonid N.Maslov Sergey V.Popov Alexandr V.Mukhomezyanov Vyacheslav V.Ryabov Boris K.Kurbatov Alexandra E.Gombozhapova Nirmal Singh Feng Fu Jian-Ming Pei Sergey V.Logvinov 

作者机构：Laboratory of Experimental CardiologyCardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatiala 147002India Department of Physiology and PathophysiologyNational Key Discipline of Cell BiologySchool of Basic MedicineFourth Military Medical UniversityXi'anShaanxi 710032China Department of HistologyEmbryology and CytologySiberian State Medical UniversityTomskTomsk Region 634055Russia 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2022年第36卷第6期

页      面：375-389页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Russian Foundation of Basic Research(Grant No.21-515-53003) 

主　　题：pyroptosis apoptosis autophagy cardiac remodeling diabetes metabolic syndrome 

摘      要：Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related *** introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in *** cardiac remodeling is a serious problem in *** increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac *** of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic ***,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered *** was demonstrated that pyroptosis interacts closely with apoptosis and *** could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.