Overloading of differentiated Caco-2 cells during lipid transcytosis induces glycosylation mistakes in the Golgi complex
作者机构：Department of AnatomySaint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of BiochemistrySaint Petersburg State Paediatric Medical UniversityPetersburg194100Russia Department of Heart and Vessel SurgerySaint Petersburg State Paediatric Medical UniversityPetersburg194100Russia The FIRC Institute of Molecular OncologyMilan20139Italy
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2021年第45卷第3期
页 面：773-783页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Golgi Blood group antigens Glycosylation errors Enterocyte Lipid transcytosis Caco-2 cells
摘 要：Overloading the intestine enterocytes with lipids induced alteration of the Golgi complex(GC;Sesorova et al.,2020)and could cause glycosylation ***,using differentiated Caco-2 cells with the established 0[I]blood group phenotype(no expression of the blood antigens A and B[AgA,AgB]under normal conditions)as a model of human enterocytes we examined whether the overloading of these cells with lipids could cause errors in the Golgi-dependent *** demonstrated that under these conditions,there were alterations of the GC and the appearance of lipid droplets in the *** cells produced AgA and *** suggested that after overloading of enterocytes with lipids,AgA were mistakenly synthesized in individual enterocytes by the Golgi *** mistakes could explain why in the absence of AgA and AgB antibodies against them exist in the blood.
维普期刊数据库