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Analysis of the Relationship between Eating and Swallowing Function and Lifestyle of the Elderly Living in the Community-A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第2期8卷 56-69页

作者： Naito Tomoyoshi Yamada Masami nakamura Mi Eiko Ojima Toshiyuki Hamamatsu Medical University Shizuoka 431-3125HamamatsuJapan Department of Nursing Faculty of Medical SciencesTeikyo University of Science and TechnologyTokyo 120-0045Japan Hamamatsu Medical University Department of Health and Social MedicineShizuoka 431-3125HamamatsuJapan

Objectives:The relationship between eating and swallowing function,and lifestyle among community-dwelling elderly people has not been extensively *** study aimed to analyze the characteristics of eating and swallowing function and their association with the lifestyle among the ***:A self-administered questionnaire survey was conducted on 419 elderly people who participated in the oral function improvement project operated by the Community Comprehensive Support Center.A total of 288 valid responses(58 males,230 females,average age 73.6 years)were *** survey items included basic demographics,health status,lifestyle,and eating and swallowing *** chi-square(χ2)test was used to compare for a difference in the risk of ***:72 patients(25.0%)were judged to be at risk for dysphagia,and 216(75.0%)were judged to be not at risk for dysphagia using the revised dysphagia risk assessment *** mean score for oral preparatory dysphagia was the highest,while the mean score for pharyngeal dysphagia was the *** group at risk of dysphagia had significant difficulty in chewing and had bad sleep quality as compared to the group that was not at ***:Concerning the risk of dysphagia,there is a need to maintain and improve masticatory *** addition,improving the swallowing function of the elderly may prevent insomnia and improve sleep quality.

关键词： Elderly living in the community Eating and swallowing function Lifestyle

Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms

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骨研究:英文版 2023年第3期11卷 617-624页

作者： Margalida Fontcuberta-Rigo Miho nakamura Pere Puigbò Medicity Research Laboratory Faculty of MedicineUniversity of TurkuTykistökatu 620520 TurkuFinland Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University2-3-10 Kanda-SurugadaiChiyodaTokyo 1010062Japan Graduate School of Engineering Tohoku University6-6 Aramaki Aza AobaAoba-kuSendaiMiyagi 9808579Japan Department of Biology University of Turku20500 TurkuFinland Eurecat Technology Center of Catalonia.Nutrition and Health UnitReus 43204 CataloniaSpain Department of Biochemistry and Biotechnology University Rovira i Virgili43007 TarragonaCataloniaSpain

The bone extracellular matrix(ECM) contains minerals deposited on highly crosslinked collagen fibrils and hundreds of noncollagenous proteins. Some of these proteins are key to the regulation of bone formation and regeneration via signaling pathways,and play important regulatory and structural roles. However, the complete list of bone extracellular matrix proteins, their roles, and the extent of individual and cross-species variations have not been fully captured in both humans and model organisms. Here, we introduce the most comprehensive resource of bone extracellular matrix(ECM) proteins that can be used in research fields such as bone regeneration, osteoporosis, and mechanobiology. The Phylobone database(available at https://***) includes 255proteins potentially expressed in the bone extracellular matrix(ECM) of humans and 30 species of vertebrates. A bioinformatics pipeline was used to identify the evolutionary relationships of bone ECM proteins. The analysis facilitated the identification of potential model organisms to study the molecular mechanisms of bone regeneration. A network analysis showed high connectivity of bone ECM proteins. A total of 214 functional protein domains were identified, including collagen and the domains involved in bone formation and resorption. Information from public drug repositories was used to identify potential repurposing of existing drugs. The Phylobone database provides a platform to study bone regeneration and osteoporosis in light of(biological) evolution,and will substantially contribute to the identification of molecular mechanisms and drug targets.

关键词： drugs matrix database

Neuromelanin-sensitive magnetic resonance imaging:a promising technique for depicting tissue characteristics containing neuromelanin

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Neural Regeneration Research 2014年第7期9卷 759-760页

作者： Ken nakamura Keizo Sugaya Department of Neurology Tokyo Metropolitan Neurological Hospital

Idiopathic Parkinson＇s disease （IPD） is a progressive, neurodegenerative movement disorder characterized by bradykinesia, muscular rigidity, pos- tural instability and tremor. IPD is usually diagnosed based on clinical findings, but diagnoses are only 75-90% accurate when compared with autopsy results. Improving diagnostic accuracy is critical for the early dif- ferentiation of IPD from other Parkinsonism-related disorders because of differences in their prognoses and treatment. Furthermore, IPD is clinically heterogeneous, with variable prognosis. Although the biological function of neuromelanin has not yet been determined, the selective vulnerability of neuromelanin-containing neurons in patients with IPD suggests a role for this pigment in neurodegeneration. Recently developed ultra-high-field magnetic resonance imaging （MRI） systems produce Tl-weighted neuro- melanin-sensitive images with very high spatial resolution, enabling the de- piction of tissue containing neuromelanin. Here we review recent advances in neuromelanin-sensitive MRI in IPD and related conditions suggesting that neuromelanin may be a potential diagnostic biomarker for IPD.

关键词： IPD Neuromelanin-sensitive magnetic resonance imaging MRI BTP

Cobalt-based magnetic Weyl semimetals with high-thermodynamic stabilities

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npj Computational Materials 2021年第1期7卷 41-48页

作者： Wei Luo Yuma nakamura Jinseon Park Mina Yoon Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Physics and Astronomy University of TennesseeKnoxvilleTN 37916USA

Recent experiments identified Co_(3)Sn_(2)S_(2) as the first magnetic Weyl semimetal(MWSM).Using first-principles calculation with a global optimization approach,we explore the structural stabilities and topological electronic properties of cobalt(Co)-based shandite and alloys,Co_(3)MM’X_(2)(M/M’=Ge,Sn,Pb,X=S,Se,Te),and identify stable structures with different Weyl *** a tight-binding model,for the first time,we reveal that the physical origin of the nodal lines of a Co-based shandite structure is the interlayer coupling between Co atoms in different Kagome layers,while the number of Weyl points and their types are mainly governed by the interaction between Co and the metal atoms,Sn,Ge,and *** Co_(3)SnPbS_(2) alloy exhibits two distinguished topological phases,depending on the relative positions of the Sn and Pb atoms:a three-dimensional quantum anomalous Hall metal,and a MWSM phase with anomalous Hall conductivity(~1290Ω^(−1) cm^(−1))that is larger than that of Co_(2)Sn_(2)S_(2).Our work reveals the physical mechanism of the origination of Weyl fermions in Co-based shandite structures and proposes topological quantum states with high thermal stability.

关键词： stability alloy magnetic

Mechanotransduction,nanotechnology,and nanomedicine

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The Journal of Biomedical Research 2021年第4期35卷 284-293页

作者： Xiaowei Liu Fumihiko nakamura School of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300072China.

Mechanotransduction,a conversion of mechanical forces into biochemical signals,is essential for human development and *** is observable at all levels ranging from the whole body,organs,tissues,organelles down to *** results in various diseases such as muscular dystrophies,hypertension-induced vascular and cardiac hypertrophy,altered bone repair and cell *** mechanotransduction occurs at nanoscale,nanosciences and applied nanotechnology are powerful for studying molecular mechanisms and pathways of *** force microscopy,magnetic and optical tweezers are commonly used for force measurement and manipulation at the single molecular *** is also used to control cells,topographically and mechanically by specific types of nano materials for tissue *** research will become increasingly important as a sub-discipline under *** we review nanotechnology approaches using force measurements and manipulations at the molecular and cellular levels during mechanotransduction,which has been increasingly play important role in the advancement of nanomedicine.

关键词： nanomedicine mechanotransduction mechanical force differentiation tissue engineering

The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models

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Neural Regeneration Research 2017年第1期12卷 43-46页

作者： Syoichi Tashiro Masaya nakamura Hideyuki Okano Department of Rehabilitation Medicine Keio University School of MedicineTokyoJapan Department of Orthopaedic Surgery Keio University School of MedicineTokyoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Regenerative medicine has opened a window for functional recovery in acute-to-subacute phase spinal cord injury（SCI）.By contrast,there are still only a few studies have focused on the treatment of the chronically injured spinal cord,in which cell-based regenerative medicine seems less *** the majority of SCI patients are in the chronic phase,representing a major challenge for the clinical application of cellbased regenerative *** combined therapies for the treatment of chronic SCI have attracted attention of researchers and its potential importance is also widely recognized,there had been very few studies involving rehabilitative treatments to *** a recent study,we have demonstrated for the first time that treadmill training combined with cell transplantation significantly promotes functional recovery even in chronic SCI,not only in additive but also in synergistic *** though we have succeeded to outline the profiles of recovery secondary to the combination therapy,the mechanism underlying the effects remain *** this review article,we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models.

关键词： transplantation spinal cord injury regenerative medicine chronic phase rehabilitation treadmill training

Blood glucose control in patients with severe sepsis and septic shock

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World Journal of Gastroenterology 2009年第33期15卷 4132-4136页

作者： Hiroyuki Hirasawa Shigeto Oda Masataka nakamura Department of Emergency and Critical Care Medicine Chiba University Graduate School of Medicine

The main pathophysiological feature of sepsis is the uncontrollable activation of both pro-and anti-inflammatory responses arising from the overwhelming pro-duction of mediators such as pro-and anti-inflammatory cytokines. Such an uncontrollable inflammatory response would cause many kinds of metabolic derangements. One such metabolic derangement is hyperglycemia. Accordingly, control of hyperglycemia in sepsis is considered to be a very effective therapeutic approach. However, despite the initial enthusiasm, recent studies reported that tight glycemic control with intensive insulin therapy failed to show a beneficial effect on mortality of patients with severe sepsis and septic shock. One of the main reasons for this disappointing result is the incidence of harmful hypoglycemia during intensive insulin therapy. Therefore, avoidance of hypoglycemia during intensive insulin therapy may be a key issue in effective tight glycemic control. It is generally accepted that glycemic control aimed at a blood glucose level of 80-100 mg/dL, as initially proposed by van den Berghe, seems to be too tight and that such a level of tight glycemic control puts septic patients at increased risk of hypoglycemia. Therefore, now many researchers suggest less strict glycemic control with a target blood glucose level of 140-180 mg/dL. Also specific targeting of glycemic control in diabetic patients should be considered. Since there is a significantcorrelation between success rate of glycemic control and the degree of hypercytokinemia in septic patients, some countermeasures to hypercytokinemia may be an important aspect of successful glycemic control. Thus, in future, use of an artificial pancreas to avoid hypoglycemia during insulin therapy, special consideration of septic diabetic patients, and control of hypercytokinemia should be considered for more effective glycemic control in patients with severe sepsis and septic shock.

关键词： Blood glucose Diabetes mellitus Insulin Hypercytokinemia Inflammation mediators

Characteristics of glucose change in diabetes mellitus generalized through continuous wavelet transform processing:A preliminary study

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World Journal of Diabetes 2023年第10期14卷 1562-1572页

作者： Yoichi nakamura Shinya Furukawa Cardiovascular Medicine&Diabetology Specified Clinic of Soyokaze CardioVascular Medicine and Diabetes CareMatsuyama 790-0026EhimeJapan Health Services Center Ehime UniversityMatsuyama 790-8577EhimeJapan

BACKGROUND The continuous glucose monitoring(CGM)system has become a popular evaluation tool for glucose fluctuation,providing a detailed description of glucose change *** hypothesized that glucose fluctuations may contain specific information on differences in glucose change between type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM),despite similarities in change patterns,because of different *** Fourier transform,continuous wavelet transform(CWT)is able to simultaneously analyze the time and frequency domains of oscillating *** To investigate whether CWT can detect glucose fluctuations in *** The 60-d and 296-d glucose fluctuation data of patients with T1DM(n=5)and T2DM(n=25)were evaluated *** data obtained every 15 min for 356 d were *** were assessed by CWT with Morlet form(n=7)as the mother *** methodology was employed to search for limited frequency glucose fluctuation in the daily glucose *** frequency and enclosed area(0.02625 scalogram value)of 18 emerged signals were *** specificity for T1DM was evaluated through multiple regression analysis using items that demonstrated significant differences between them as explanatory *** The high frequency at midnight(median:75 Hz,cycle time:19 min)and middle frequency at noon(median:45.5 Hz,cycle time:32 min)were higher in T1DM vs T2DM(median:73 and 44 Hz;P=0.006 and 0.005,respectively).The area of the>100 Hz zone at midnight to forenoon was more frequent and larger in T1DM vs *** a day,the lower frequency zone(15-35 Hz)was more frequent and the area was larger in T2DM than in *** threedimensional scatter diagrams,which consist of the time of day,frequency,and area of each signal after CWT,revealed that high frequency signals belonging to T1DM at midnight had a loose distribution of wave cycles that were 17-24 *** analysis revealed that the high frequency signal at midnight could c

关键词： Continuous glucose monitoring Pathophysiology Fourier,Pseudo-frequency Contour map Scalogram matrix

Uniform Regularity for the Isentropic Compressible Magnetohydrodynamic System

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 410-416页

作者： Ji-shan FAN Fu-cai LI GEN nakamura Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan

In this paper we first establish the uniform regularity of smooth solutions with respect to the viscosity coefficients to the isentropic compressible magnetohydrodynamic system in a periodic domain T;.We then apply ou... 详细信息

关键词： isentropic compressible magnetohydrodynamic system uniform regularity