Mechanotransduction,nanotechnology,and nanomedicine

作     者：Xiaowei Liu Fumihiko Nakamura Xiaowei Liu;Fumihiko Nakamura

作者机构：School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China. 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2021年第35卷第4期

页      面：284-293页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：the National Natural Science Foundation of China(Grant No.31771551 to F.N.) 

主　　题：nanomedicine mechanotransduction mechanical force differentiation tissue engineering 

摘      要：Mechanotransduction,a conversion of mechanical forces into biochemical signals,is essential for human development and *** is observable at all levels ranging from the whole body,organs,tissues,organelles down to *** results in various diseases such as muscular dystrophies,hypertension-induced vascular and cardiac hypertrophy,altered bone repair and cell *** mechanotransduction occurs at nanoscale,nanosciences and applied nanotechnology are powerful for studying molecular mechanisms and pathways of *** force microscopy,magnetic and optical tweezers are commonly used for force measurement and manipulation at the single molecular *** is also used to control cells,topographically and mechanically by specific types of nano materials for tissue *** research will become increasingly important as a sub-discipline under *** we review nanotechnology approaches using force measurements and manipulations at the molecular and cellular levels during mechanotransduction,which has been increasingly play important role in the advancement of nanomedicine.