Neuromelanin-sensitive magnetic resonance imaging:a promising technique for depicting tissue characteristics containing neuromelanin

作     者：Ken Nakamura Keizo Sugaya 

作者机构：Department of Neurology Tokyo Metropolitan Neurological Hospital 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第7期

页      面：759-760页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：IPD Neuromelanin-sensitive magnetic resonance imaging MRI BTP 

摘      要：Idiopathic Parkinson＇s disease （IPD） is a progressive, neurodegenerative movement disorder characterized by bradykinesia, muscular rigidity, pos- tural instability and tremor. IPD is usually diagnosed based on clinical findings, but diagnoses are only 75-90% accurate when compared with autopsy results. Improving diagnostic accuracy is critical for the early dif- ferentiation of IPD from other Parkinsonism-related disorders because of differences in their prognoses and treatment. Furthermore, IPD is clinically heterogeneous, with variable prognosis. Although the biological function of neuromelanin has not yet been determined, the selective vulnerability of neuromelanin-containing neurons in patients with IPD suggests a role for this pigment in neurodegeneration. Recently developed ultra-high-field magnetic resonance imaging （MRI） systems produce Tl-weighted neuro- melanin-sensitive images with very high spatial resolution, enabling the de- piction of tissue containing neuromelanin. Here we review recent advances in neuromelanin-sensitive MRI in IPD and related conditions suggesting that neuromelanin may be a potential diagnostic biomarker for IPD.