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Inhibitory effect of a new gossypol derivative apogossypolone (ApoG2) on xenograft of human prostate cancer cell line PC-3

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Journal of Medical Colleges of PLA(China) 2009年第5期24卷 274-282页

作者： Zhang Xianqing Huang Xiaofeng mu shijie Chen Rui An Qunxing Xia Aijun Wu Daocheng Department of Blood Transfusion Xijing Hospital Fourth Military Medical University Xi 'an 710032 China Central Laboratory Fourth Military Medical University Xi 'an 710032 China Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University Xi 'an 710038 China

Objective: To investigate the inhibitory effect of apogossypolone (ApoG2) on prostate cancer cell line PC-3 in vivo, and explore its mechanism. Methods: The models of transplantation tumors in Balb/c nu/nu mice were established via subcutaneous injection of PC-3 cells and the tumor-transplanted mice were divided into 4 groups: control group and three ApoG2 treatment groups, with 10 mice in each group. Volumes of the tumor were estimated every 2 d and the morphology of tumor tissues was observed. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and caspase-8 in tumor tissues. Results: ApoG2 (2.5 mg/kg-10 mg/kg) given intraperitoneally once a day can obviously inhibit the growth of subcutaneous prostatic carcinoma implant. The tumor volume decreased obviously when the treatment dosage was bigger than 5.0 mg/kg (P<0.01). Meanwhile, ApoG2 decreased the expression of PCNA and CD31, and enhanced the expression of caspases-3, caspase-8 in tumor tissues. Conclusion: ApoG2 exert an inhibitory effect on prostatic carcinoma possibly by inducing apoptosis and inhibiting tumor angiogenesis.

关键词： Apogossypolone Prostate cancer PC-3 human prostatic carcinoma cell line Xenograft

Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： shijie Tang Yong Ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

血栓弹力图与T2DM合并冠心病患者血清铁蛋白的相关性分析

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中国输血杂志 2016年第9期29卷 929-931页

作者：陈洁崔颖穆士杰第四军医大学唐都医院输血科陕西西安710038

目的探讨血栓弹力图(TEG)参数与血清铁蛋白(SF)在2型糖尿病(T2DM)合并冠心病患者之间的关系,监测患者的凝血状态,指导临床治疗。方法选取住院期间T2DM合并冠心病患者170例和正常对照组90例,将其血液做生化检测、血栓弹力图测定并进行统... 详细信息

目的探讨血栓弹力图(TEG)参数与血清铁蛋白(SF)在2型糖尿病(T2DM)合并冠心病患者之间的关系,监测患者的凝血状态,指导临床治疗。方法选取住院期间T2DM合并冠心病患者170例和正常对照组90例,将其血液做生化检测、血栓弹力图测定并进行统计学分析比较。结果 1)T2DM合并冠心病患者与正常对照组相比,空腹血糖(FPG)、糖化血红蛋白(Hb Alc)、血清铁蛋白(SF)均升高,且差异有统计学意义(P<0.05);2)与正常对照组相比,T2DM合并冠心病组的TEG参数R值、K值、a角、MA值、CI值均具有统计学意义(P<0.05);3)T2DM合并冠心病患者的血清铁蛋白(SF)与TEG参数中的CI、a角以及空腹血糖(FPG)和糖化血红蛋白(Hb Alc)均呈正相关性(P<0.05);与TEG参数中的R值呈负相关性(P<0.05)。结论血清铁蛋白(SF)与TEG参数具有相关性,可以在一定程度上作为监测T2DM合并冠心病患者的凝血状态的指标,用于指导临床治疗。

关键词：血栓弹力图血清铁蛋白 2型糖尿病合并冠心病

Inhibitory effects of apogossypolone on subcutaneous implants of human LNCaP prostatic carcinoma cells

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The Chinese-German Journal of Clinical Oncology 2012年第1期11卷 33-36页

作者： Yaozhen Chen Haishan Chen Chen Chen Xiaofeng Huang shijie mu Mengyao Zhang Xingbin Hu Qunxing An Xianqing Zhang Department of Blood Transfusion Xijing Hospital The Fourth Military Medical University Xi＇an 710032 China Department of Blood Transfusion 210 Hospital of PLA Dalian 116000 China Central laboratory The Fourth Military Medical University Xi＇an 710032 China Department of Chemistry School of Pharmacy The Fourth Military Medical University Xi＇an 710032 China

Objective:The aim of this study was to investigate the inhibitory effect of apogossypolone (ApoG2) on subcutaneous implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. Methods:To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. The microvessel density was calculated. Results:ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion:ApoG2 has an inhibitory effect on prostatic carcinoma implants.

关键词： apogossypolone (ApoG2) prostate cancer LNCaP human prostatic carcinoma cell line transplantation

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中成药引起药物抗体检测方法的建立

临床血液学杂志 2021年第12期34卷 871-873,877页

作者：陈洁杜娟向东穆士杰空军军医大学第二附属医院输血科西安710000 上海血液中心

目的:建立中成药引起药物抗体的检测方法,使用该检测方法对1例服用"三十五味沉香丸"疑似引起药物诱导型免疫溶血性贫血患者进行药物抗体检测,探讨实验室检测中成药药物抗体的必要性及检测方法的可操作性。方法:用药物致敏红细胞法和免... 详细信息

目的:建立中成药引起药物抗体的检测方法,使用该检测方法对1例服用"三十五味沉香丸"疑似引起药物诱导型免疫溶血性贫血患者进行药物抗体检测,探讨实验室检测中成药药物抗体的必要性及检测方法的可操作性。方法:用药物致敏红细胞法和免疫复合物法2种检测方法,在微柱凝胶中通过间接抗人球蛋白试验检测血清中的药物抗体,以确定服用中成药产生药物抗体的机制、抗体产生情况。结果:中成药通过半抗原机制刺激机体产生抗体,患者服用"三十五味沉香丸"后3次送检血清的检测结果显示,药物致敏红细胞可以和患者血清在抗人球介质中发生凝集反应。结论:建立了使用微柱凝胶法在抗人球介质中检测中成药引起药物抗体的方法,证明该中成药通过半抗原机制刺激机体产生免疫性抗体,并引起药物诱导型免疫性溶血性贫血。

关键词：抗体中成药免疫性溶血

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红细胞制剂血辫质量的监测分析

临床血液学杂志 2023年第4期36卷 292-294页

作者：王文婷郑妍王林穆士杰空军军医大学唐都医院输血科西安710038

目的:通过红细胞制剂血辫质量的调查分析,探讨血辫质量对临床用血安全的重要性。方法:统计分析血站供应红细胞制剂10902 U共计6953份血辫的长度、抗凝情况、溶血情况及对输血前相容性检测试验的影响,判断血辫质量。结果:6953份血辫总长... 详细信息

目的:通过红细胞制剂血辫质量的调查分析,探讨血辫质量对临床用血安全的重要性。方法:统计分析血站供应红细胞制剂10902 U共计6953份血辫的长度、抗凝情况、溶血情况及对输血前相容性检测试验的影响,判断血辫质量。结果:6953份血辫总长度均符合要求,其中分段<5 cm占1.47%(102/6953);不抗凝血辫占5.55%(386/6953);保存第30天血辫溶血率为6.70%(466/6953)。结论:抗凝良好、足够长度的血辫能反映血袋中血液的免疫性状态,满足输血前相容性检测试验要求,确保临床输血安全。

关键词：血辫输血红细胞制剂

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

RhD、RhCE、RhAG3种蛋白的分子结构及其关系

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中国输血杂志 2016年第9期29卷 1083-1085页

作者：包汝娟崔颖魏华穆士杰第四军医大学唐都医院输血科陕西西安710038

Rh血型系统是人类最复杂和最重要的血型系统之一,它包含了数量庞大的致敏原,可导致严重的新生儿溶血病。我们目前已知的基因克隆和功能性的证据表明,Rh蛋白(RhD和RhCE)是Rh血型系统中非常重要的2种蛋白,不仅是许多抗原以及表型的分子基... 详细信息

Rh血型系统是人类最复杂和最重要的血型系统之一,它包含了数量庞大的致敏原,可导致严重的新生儿溶血病。我们目前已知的基因克隆和功能性的证据表明,Rh蛋白(RhD和RhCE)是Rh血型系统中非常重要的2种蛋白,不仅是许多抗原以及表型的分子基础,还是一类涉及氨转运的膜蛋白。RhAG蛋白作为Rh相关糖蛋白,可以辅助Rh蛋白锚定在红细胞膜上,影响RhD抗原的表达;同时它还可以结合Rh蛋白形成复合体,参与红细胞膜上氨的跨膜转运。本文综述了RhD、RhCE、RhAG 3种蛋白的分子结构,及它们之间相互关系的研究进展。

关键词： RhD RhCE RhAG

贮存式自身输血在异基因造血干细胞移植供者中的应用

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中国输血杂志 2017年第7期30卷 721-723页

作者：王文婷郑妍魏华穆士杰第四军医大学唐都医院输血科陕西西安710038

目的探寻贮存式自身输血在异基因造血干细胞移植供者中的应用效果。方法回顾性分析2013-2016年本院进行贮存式自身输血的127例异基因造血干细胞移植供者的造血干细胞采集及自体血回输情况。结果 127例供者共采集自体血70 550 m L,仅2例... 详细信息

目的探寻贮存式自身输血在异基因造血干细胞移植供者中的应用效果。方法回顾性分析2013-2016年本院进行贮存式自身输血的127例异基因造血干细胞移植供者的造血干细胞采集及自体血回输情况。结果 127例供者共采集自体血70 550 m L,仅2例出现轻度献血反应,不良反应发生率为1.6%(2/127);采集骨髓血100 159m L。117例供者骨髓血采集前WBC(27.02±8.21)×1010/L、Plt(213.19±62.42)×109/L、RBC(4.31±0.44)×1012/L、Hb(131.53±14.53)g/L,自体血回输后1d WBC(35.85±9.08)×1010/L、Plt(188.34±50.24)×109/L、RBC(4.02±0.41)×1012/L、Hb(122.60±13.48)g/L。自体血回输后1 d造血干细胞供者WBC明显高于采髓前(P<0.05),Plt、RBC、Hb明显减低(P<0.05)。结论贮存式自身输血能节约血液资源,防止输血相关疾病发生,可应用于造血干细胞供者。

关键词：贮存式自身输血造血干细胞供者