Inhibitory effects of apogossypolone on subcutaneous implants of human LNCaP prostatic carcinoma cells

作     者：Yaozhen Chen Haishan Chen Chen Chen Xiaofeng Huang Shijie Mu Mengyao Zhang Xingbin Hu Qunxing An Xianqing Zhang 

作者机构：Department of Blood Transfusion Xijing Hospital The Fourth Military Medical University Xi＇an 710032 China Department of Blood Transfusion 210 Hospital of PLA Dalian 116000 China Central laboratory The Fourth Military Medical University Xi＇an 710032 China Department of Chemistry School of Pharmacy The Fourth Military Medical University Xi＇an 710032 China 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2012年第11卷第1期

页      面：33-36页

学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 0905[农学-畜牧学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 090501[农学-动物遗传育种与繁殖] 

主　　题：apogossypolone (ApoG2) prostate cancer LNCaP human prostatic carcinoma cell line transplantation 

摘      要：Objective:The aim of this study was to investigate the inhibitory effect of apogossypolone (ApoG2) on subcutaneous implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. Methods:To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. The microvessel density was calculated. Results:ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion:ApoG2 has an inhibitory effect on prostatic carcinoma implants.