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Geochemistry of magnetite in beach sands, stream sediments,and in situ magnetites in surrounding rocks at north Taiwan island

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Acta Geochimica 2022年第3期41卷 434-452页

作者： eslam mohammed Ali Mitwally Bing-Sheng Yu Institute of Mineral Resources Engineering National Taipei University of TechnologyTaipeiTaiwanRepublic of China Geology Department Faculty of ScienceAl Azhar UniversityAsyuˆtEgypt

The geochemistry of magnetite provides constraints on the source(s) of the magnetite and other ore minerals. In this study, we constructed a magnetite distribution map, compared the chemical composition of magnetite present in hard rocks with that present in sand beach and stream deposits to determine magnetite’s provenance,investigated relationships among different trace elements,examined variations in the concentrations of trace elements present in magnetite, and identified the type of studied magnetite. Laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and inductively coupled plasma mass spectrometry/inductively coupled plasma atomic emission spectroscopy was used to analyze samples available in small and large amounts, respectively. The average magnetite compositions of beach and river samples were substantially similar to those of andesite rocks,revealing that the magnetite samples may have originated from surrounding andesite rocks;this finding is consistent with the chemical composition of the samples analyzed using LA-ICP-MS. Some of the andesite rocks found in the study area were the primary source of magnetite aggregations in the beach sands and stream sands near or slightly away from these rocks. High Ti–V magnetites lie within the fields of Fe–Ti–V bearing magnetite and titanomagnetite(ulv?spinel). These titanomagnetites may be undergoing transformation to spinel minerals such as galaxite,gahnite, magnesiochromite, and chromite, which are characterized by the high concentrations of Al, Ti, Mg, Cr,Ni, Mn, and Zn. The positive correlation between Fe and Ti, Cr and Ni, and also the negative correlation between Fe and Mg, Mn and Zn can be attributed to various magnetite phases present in the study area. V, Co, Mo, Nb, Ga, Sn,and Ta exhibited a positive correlation with Fe and a negative correlation with Al. The positive correlation between Fe and these elements indicates the enrichment of these elements in the magnetite series. We observ

关键词： Magnetite chemistry LA-ICP-MS Element incorporation Multi variation diagram Distribution map North Taiwan

Metabolic associated fatty liver disease and cancer risk: causal role or epiphenomenon?

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 774-776页

作者： Ali Bayoumi mohammed Shatat mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadNSWAustralia Department of Internal Medicine Faculty of MedicineMinya University HospitalMinyaEgypt

The majority of global deaths are attributed to one of the noncommunicable diseases(NCDs),and cancer is projected to be the leading cause of death worldwide in the 21st century(1).There were 18.1 million incident cancer cases worldwide in 2018,43.8 million are living with cancer and 9.6 million deaths from *** in 6 deaths is due to cancer and these numbers are projected to rise to 13 million by 2030,more than that from tuberculosis,malaria and HIV/AIDS *** addition,the total annual global cost of cancer was estimated at around US$1.16 trillion,representing a significant burden on health care systems and families(1).

关键词： cancer diseases tuberculosis

Metabolic associated fatty liver disease(MAFLD):a milestone in the history of fatty liver disease

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 696-698页

作者： Jawaher Alharthi mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia

With the widespread increase in energy intake and physical inactivity,the prevalence of metabolic health is ***,metabolic associated fatty liver disease(MAFLD)[formerly known as non-alcoholic fatty liver disease(NAFLD)]has risen in prevalence and present a significant challenge to global health causing considerable morbidity and mortality,particularly when fibrosis is present(1).

关键词： liver NAFLD MAF

Macrophages in metabolic associated fatty liver disease

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World Journal of Gastroenterology 2020年第16期26卷 1861-1878页

作者： Jawaher Alharthi Olivier Latchoumanin Jacob George mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydney 2145NSWAustralia

Metabolic associated fatty liver disease(MAFLD),formerly named non-alcoholic fatty liver disease is the most common liver disorder in many *** inflammatory subtype termed steatohepatitis is a driver of disease progression to cirrhosis,hepatocellular carcinoma,liver transplantation,and death,but also to extrahepatic complications including cardiovascular disease,diabetes and chronic kidney *** plasticity of macrophages in response to various environmental cues and the fact that they can orchestrate cross talk between different cellular players during disease development and progression render them an ideal target for drug *** report reviews recent advances in our understanding of macrophage biology during the entire spectrum of MAFLD including steatosis,inflammation,fibrosis,and hepatocellular carcinoma,as well as for the extra-hepatic manifestations of *** discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes,hepatic stellate cells,and adipose *** conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD.

关键词： Metabolic associated fatty liver disease Macrophages Inflammation Fibrosis Hepatic stellate cells

The role of B cells in metabolic(dysfunction)-associated fatty liver disease

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 875-877页

作者： Ziyan Pan Wah-Kheong Chan mohammed eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia

Metabolic(dysfunction)-associated fatty liver disease(MAFLD;formerly known as non-alcoholic fatty liver disease)is the most common liver disorder,affecting around one-third of the population worldwide(1).MAFLD is a heterogeneous disease with a spectrum of liver pathologies that spans from hepatic lipid accumulation(steatosis)to chronic inflammation(steatohepatitis),which can progress to cirrhosis and hepatocellular *** is impacted by a myriad of factors,including metabolic health,biological and chronological age,genetics and epigenetics(2-4).However,only a proportion(5-40%)of patients develop liver inflammation or steatohepatitis(5).This transition is a cardinal feature of progressive liver disease,which is the precursor to the development of the hepatic and extra-hepatic outcomes.

关键词： inflammation hepatic liver

When a new definition overhauls perceptions of MAFLD related cirrhosis care

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 801-804页

作者： Kenneth I.Zheng mohammed eslam Jacob George Ming-Hua Zheng MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouChina

Metabolic-associated fatty liver disease(MAFLD)(1),formerly known as non-alcoholic fatty liver disease,is a major causes of liver cirrhosis(2).MAFLD represents a growing global health and economic burden since approximately one in four people have the disease(3).As a consequence,MAFLD-related cirrhosis is expected to become the leading cause for liver failure and liver cancer,and the major indication for liver transplantation this century(3).

关键词： cirrhosis MAF Metabolic

From NAFLD to MAFLD:a“redefining”moment for fatty liver disease

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Chinese Medical Journal 2020年第19期133卷 2271-2273页

作者： Kenneth IZheng Jian-Gao Fan Jun-Ping Shi Vincent Wai-Sun Wong mohammed eslam Jacob George Ming-Hua Zheng Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 25000China Department of Gastroenterology Center for Fatty LiverXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Pediatric Gastroenterology and NutritionShanghai 200065China Department of Liver Diseases Hangzhou Normal University Affiliated HospitalHangzhouZhejiang 311121China Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydney 2145Australia Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiang 325000China Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiang 325000China.

The term non-alcoholic fatty liver disease(NAFLD)was coined in 1980 to characterize a disease similar to alcoholic fatty liver disease that developed in patients without a history of excessive alcohol intake.[1]Morphologically,NAFLD is characterized by excess fatty infiltration of the liver in the absence of known causes of liver disease(eg,alcohol,autoimmune liver disease,viral hepatitis,etc).The clinical manifestations of NAFLD(both hepatic and extrahepatic)depend on the outcome of complex interactions between its primary drivers including poor lifestyle habits and diet,a dysfunctional microbiota,genetic predisposition,and environmental cues that result in metabolic dysfunction and liver ***,bringing all patients with their markedly different clinical courses under the NAFLD umbrella belies its complexity and implies a homogeneous disease state that then negatively impacts clinical management and a deeper understanding of *** advances in current knowledge on the spectrum of fatty liver diseases,it is apparent that the fourdecade-old outdated term NAFLD can no longer serve to usefully describe a highly heterogeneous *** disease as we understand it today not only impacts patients who consume alcohol and those who do not,but also potentially impacts all patients with any form of liver disease,by acting as a disease modifier.[2]

关键词： NAFLD Morphological markedly

Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection

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World Journal of Gastroenterology 2013年第41期19卷 7055-7061页

作者： mohammed eslam David R Booth Jacob George Golo Ahlenstiel Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia

Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)***,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in *** emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin *** review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.

关键词： IFNL3 Chronic hepatitis C Insulin resistance Lipids

Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolicassociated Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 194-202页

作者： Wen-Yue Liu mohammed eslam Kenneth I.Zheng Hong-Lei Ma Rafael S.Rios Min-Zhi Lv Gang Li Liang-Jie Tang Pei-Wu Zhu Xiao-Dong Wang Christopher D.Byrne Giovanni Targher Jacob George Ming-Hua Zheng Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadSydneyAustralia NAFLD Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiChina Department of Laboratory Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiangChina

Background and Aims:In Europeans,variants in the hydroxysteroid 17-beta dehydrogenase 13(HSD17B13)gene impact liver histology in metabolic-associated fatty liver disease(MAFLD).The impact of these variants in ethnic Chinese is *** aim of this study was to investigate the potential associations in Chinese ***:In total,427 Han Chinese with biopsy-confirmed MAFLD were *** single nucleotide polymorphisms in HSD17B13 were genotyped:rs72613567 and *** regression was used to test the association between the single nucleotide polymorphisms and liver ***:In our cohort,the minor allele TA of the rs72613567 variant was related to an increased risk of fibrosis[odds ratio(OR):2.93(1.20–7.17),p=0.019 for the additive model;OR:3.32(1.39–7.91),p=0.007 for the recessive model],representing an inverse association as compared to the results from European *** contrast,we observed a protective effect on fibrosis for the minor A allele carriers of the HSD17B13 rs6531975 variant[OR:0.48(0.24–0.98),p=0.043 for the additive model;OR:0.62(0.40–0.94),p=0.025 for the dominant model].HSD17B13 variants were only associated with fibrosis but no other histological ***,HSD17B13 rs6531975 modulated the effect of PNPLA3 rs738409 on hepatic ***:HSD17B13 rs72613567 is a risk variant for fibrosis in a Han Chinese MAFLD population but with a different direction for allelic association to that seen in *** data exemplify the need for studying diverse populations in genetic studies in order to fine map genome-wide association studies signals.

关键词： Metabolic-associated fatty liver disease(MAFLD) Nonalcoholic fatty liver disease(NAFLD) Hydroxysteroid 17-beta dehydrogenase 13(HSD17B13) Single nucleotide polymorphism(SNP)