Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolicassociated Fatty Liver Disease
作者机构：Department of EndocrinologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Storr Liver CentreWestmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadSydneyAustralia NAFLD Research CenterDepartment of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of BiostatisticsZhongshan HospitalFudan UniversityShanghaiChina Department of Laboratory MedicineThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of HepatologyWenzhou Medical UniversityWenzhouZhejiangChina Southampton National Institute for Health Research Biomedical Research CentreUniversity Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of EndocrinologyDiabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang ProvinceWenzhouZhejiangChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2021年第9卷第2期
页 面：194-202页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by grants from the National Natural Science Foundation of China(82070588) High Level Creative Talents from Department of Public Health in Zhejiang Province(S2032102600032) Project of New Century 551 Talent Nurturing in Wenzhou.GT was supported in part by grants from the University School of Medicine of Verona(Verona,Italy) CDB was supported in part by the Southampton NIHR Biomedical Research Centre(ISBRC-20004) UK.ME and JG were supported by the Robert W.Storr Bequest to the Sydney Medical Foundation,University of Sydney(Sydney,Australia)and the National Health and Medical Research Council of Australia(NHMRC)Program(APP1053206,APP1149976) Project(APP1107178 and APP1108422)grants
主 题：Metabolic-associated fatty liver disease(MAFLD) Nonalcoholic fatty liver disease(NAFLD) Hydroxysteroid 17-beta dehydrogenase 13(HSD17B13) Single nucleotide polymorphism(SNP)
摘 要：Background and Aims:In Europeans,variants in the hydroxysteroid 17-beta dehydrogenase 13(HSD17B13)gene impact liver histology in metabolic-associated fatty liver disease(MAFLD).The impact of these variants in ethnic Chinese is *** aim of this study was to investigate the potential associations in Chinese ***:In total,427 Han Chinese with biopsy-confirmed MAFLD were *** single nucleotide polymorphisms in HSD17B13 were genotyped:rs72613567 and *** regression was used to test the association between the single nucleotide polymorphisms and liver ***:In our cohort,the minor allele TA of the rs72613567 variant was related to an increased risk of fibrosis[odds ratio(OR):2.93(1.20–7.17),p=0.019 for the additive model;OR:3.32(1.39–7.91),p=0.007 for the recessive model],representing an inverse association as compared to the results from European *** contrast,we observed a protective effect on fibrosis for the minor A allele carriers of the HSD17B13 rs6531975 variant[OR:0.48(0.24–0.98),p=0.043 for the additive model;OR:0.62(0.40–0.94),p=0.025 for the dominant model].HSD17B13 variants were only associated with fibrosis but no other histological ***,HSD17B13 rs6531975 modulated the effect of PNPLA3 rs738409 on hepatic ***:HSD17B13 rs72613567 is a risk variant for fibrosis in a Han Chinese MAFLD population but with a different direction for allelic association to that seen in *** data exemplify the need for studying diverse populations in genetic studies in order to fine map genome-wide association studies signals.
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