From NAFLD to MAFLD:a“redefining”moment for fatty liver disease

作     者：Kenneth IZheng Jian-Gao Fan Jun-Ping Shi Vincent Wai-Sun Wong Mohammed Eslam Jacob George Ming-Hua Zheng Zheng Kenneth I.;Fan Jian-Gao;Shi Jun-Ping;Wong Vincent Wai-Sun;Eslam Mohammed;George Jacob;Zheng Ming-Hua

作者机构：Department of HepatologyMAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 25000China Department of GastroenterologyCenter for Fatty LiverXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Pediatric Gastroenterology and NutritionShanghai 200065China Department of Liver DiseasesHangzhou Normal University Affiliated HospitalHangzhouZhejiang 311121China Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong Kong 999077China Storr Liver CentreWestmead Institute for Medical ResearchWestmead Hospital and University of SydneySydney 2145Australia Institute of HepatologyWenzhou Medical UniversityWenzhouZhejiang 325000China Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang ProvinceWenzhouZhejiang 325000China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第19期

页      面：2271-2273页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Robert W.Storr Bequest to the Sydney Medical Foundation,University of Sydney a National Health and Medical Research Council of Australia(NHMRC)Program Grant(No.APP1053206 and APP1149976) Project grants(No.APP1107178 and APP1108422) Ming-Hua Zheng is supported by grants from the National Natural Science Foundation of China(No.81500665) High Level Creative Talents from Department of Public Health in Zhejiang Province and Project of New Century 551 Talent Nurturing in Wenzhou 

主　　题：NAFLD Morphological markedly 

摘      要：The term non-alcoholic fatty liver disease(NAFLD)was coined in 1980 to characterize a disease similar to alcoholic fatty liver disease that developed in patients without a history of excessive alcohol intake.[1]Morphologically,NAFLD is characterized by excess fatty infiltration of the liver in the absence of known causes of liver disease(eg,alcohol,autoimmune liver disease,viral hepatitis,etc).The clinical manifestations of NAFLD(both hepatic and extrahepatic)depend on the outcome of complex interactions between its primary drivers including poor lifestyle habits and diet,a dysfunctional microbiota,genetic predisposition,and environmental cues that result in metabolic dysfunction and liver ***,bringing all patients with their markedly different clinical courses under the NAFLD umbrella belies its complexity and implies a homogeneous disease state that then negatively impacts clinical management and a deeper understanding of *** advances in current knowledge on the spectrum of fatty liver diseases,it is apparent that the fourdecade-old outdated term NAFLD can no longer serve to usefully describe a highly heterogeneous *** disease as we understand it today not only impacts patients who consume alcohol and those who do not,but also potentially impacts all patients with any form of liver disease,by acting as a disease modifier.[2]