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A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1042-1049页

作者： Jieling Xiao Cheng-Han Ng Yip-Han Chin Darren Jun Hao Tan Wen-Hui Lim Grace Lim Jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.Chan Mazen Noureddin mohammad shadab siddiqui Arun J.Sanyaland Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingapore Lee Kong Chian School of Medicine Nan-yang Technological UniversitySingapore Department of Cardiology National University Heart CenterNational University HospitalSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Center for Organ Transplantation National University Health SystemSingapore NAFLD Research Center Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California at San DiegoLa JollaCAUSA Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyoJapan Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehen-sive Transplant CenterCedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid ***:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH *** were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the *** acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with *** top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with *** found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile ***:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic *** studies are required to evaluate the cardiovascular outcomes.

关键词： Lipid modulation NASH Dyslipidemia

Foregut bypass *** bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 658-670,I0001-I0003页

作者： Wen Hui Lim Snow Yunni Lin Cheng Han Ng Darren Jun Hao Tan Jieling Xiao Jie Ning Yong Phoebe Wen Lin Tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin Arun J.Sanyal mohammad shadab siddiqui Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Endocrinology Department of MedicineNational University HospitalSingaporeSingapore Department of Cardiology National University Heart CentreNational University HospitalSingaporeSingapore Division of General Surgery(Upper Gastrointestinal Surgery) Department of SurgeryNational University HospitalSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehensive Transplant CenterCedars-Sinai Medical CentreLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological ***,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with ***:Medline and Embase were searched for articles relating to bariatric procedures and *** meta-analysis was conducted to compare efficacy of bariatric procedures ***-procedure with subgroup analysis to further compare restrictive against foregut bypass ***:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were *** foregut bypass(P<0.01)and restrictive procedures(P=0.03)significantly increased odds of fibrosis *** to restrictive procedures,foregut bypass resulted in a borderline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(P<0.001).For metabolic parameters,foregut bypass significantly lowered body mass index(P=0.003)and low-density lipoprotein(P=0.008)compared to restrictive *** significant differences were observed between both procedures for aspartate aminotransferase(P=0.17)and alkaline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management.

关键词： Bariatric surgery non-alcoholic fatty liver disease(NAFLD) obesity fibrosis endoscopy

Lithium-Doped CuO Nanosheets:Structural Transformation,Optical,and Electrical Characteristics with Enhanced Photocatalytic and Solar Cell Performance

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Energy & Environmental Materials 2021年第4期4卷 646-657页

作者： Hafsa siddiqui mohammad Shums Qureshi Fozia Z.Haque Optical Nanomaterial Lab Department of PhysicsMaulana Azad National Institute of TechnologyBhopal 462003India Department of Physics Sha-Shib College of Science and ManagementBhopal 462036India

Energy and environmental stuff are two of the main worries for humanity,and nanoscience plays a key role in providing the *** nanoresearch activities have attracted lot of attention in the current ***,designing the material with enhanced optoelectronic properties remains the foremost *** the present work,the Li doped CuO nanosheets are synthesized by the chemical route and examined in photovoltaics and environmental remediation *** crystallographic and optical study reveals that crystallite size and bandgap decrease with an increase in lithium-doping concentration up to 5 mole%and beyond that a reverse trend is ***,impedance study has shown the significant contribution of lithium-ions to the total capacitance and ***,the photoactivity of Cu_(1-x)Li_(x)O nanosheets(optimum concentration of Cu_(1-x)Li_(x)O NSs(x=0.05))is projected to the degradation of methylene blue(MB)and used to fabricate bulk heterojunction solar cell together with P3HT and PCBM blend,*** ITO/PEDOT:PSS/P3 HT:PC_(70)BM:Cu_(1-x)Li_(x)O(x=0.05)/Li F/Al solar cell realized higher power-conversion efficiencyη~3.91 than their corresponding pristine deviceη~2.98 with enhanced photocurrent density from 9.026 to 11.56 m A cm^(-2).The proliferation in photocatalysts and solar cells efficiency of Cu_(1-x)Li_(x)O(x=0.05)is mainly attributed to the higher light absorption and lesser electron-hole *** approach for the synthesis of Cu_(1-x)Li_(x)O NSs as potential donor material and device prototypes fabricated is completely safe and cost-effective.

关键词： current density efficiency nanostructures photocatalysts solar cells

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Solubilization of Phenanthrene and Fluorene in Equimolar Binary Mixtures of Gemini/Conventional Surfactants

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Chinese Journal of Chemical Engineering 2014年第9期22卷 1009-1015页

作者： Huma siddiqui mohammad Kamil Manorama Panda Kabir-ud-Din Department of Petroleum Studies Aligarh Muslim University Department of Chemistry Aligarh Muslim University

This study deals with the enhanced solubilization of polycyclic aromatic hydrocarbons （PAHs） such as phenanthrene （PHE） and fluorene （FLR） in a pure cationic gemini （G6） and three conventional surfactants [polyethylene glycol dodecyl ether （Brij35）, cetyltrimethyl ammonium bromide （CRAB） and sodium lauryl sulfate （SDS）] as well as in their equimolar binary combinations （G6-Brij35, G6-CTAB and G6-SDS）. Their solubilization efficiency toward PHE and FLR has been quantified in terms of the molar solubilization ratio （MSR） and the micelle-water partition coefficient （Kin）. The ideality/nonideality of the mixed micelles is discussed with the help of Clint, Rubingh and Rosen＇s approaches. These theories determine the deviation of experimental critical micelle concen- tration （CMC） values from ideal critical micelle concentration, which was measured by evaluating the interaction parameters （/3m and/3）. Negative values ofβm were observed in all the equimolar binary systems, which show synergism in the mixed micelles. Whereas at air/liquid interface synergism was observed in the systems G6-CrAB and G6-Brij35; G6-SDS exhibited an antagonistic effect. The order of MSR and Km was G6-CTAB 〉 G6- Brij35 〉 G6-SDS for phenanthrene as well as for fluorene.

关键词： Gemini suffactantMixed micellesCritical micelle concentrationSolubilizationMolar solubilization ratio

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Investigation on the process parameters of TIG-welded aluminum alloy through mechanical and microstructural characterization

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Defence Technology（防务技术） 2021年第4期17卷 1234-1248页

作者： Muhammad Samiuddin Jing-long Li Muhammad Taimoor mohammad Nouman siddiqui Sumair Uddin siddiqui Jiang-tao Xiong State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072PR China Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical UniversityXi’an710072PR China Metallurgical Engineering Department NED University of Engineering and TechnologyKarachi75850Pakistan Department of Aeronautics and Astronautics Institute of Space TechnologyIslamabad44000Pakistan

Multi-pass TIG welding was conducted on plates(15×300×180 mm^(3))of aluminum alloy Al-5083 that usually serves as the component material in structural applications such as cryogenics and chemical processing *** formation and solidification cracking are the most common defects when TIG welding Al-5083 alloy,which is sensitive to the welding heat *** the experiment,the heat input was varied from 0.89 kJ/mm to 5 kJ/mm designed by the combination of welding torch travel speed and welding ***,micro-Vicker hardness and Charpy impact tests were executed to witness the impetus response of heat input on the mechanical properties of the *** inspection was performed to assess the joint’s quality and welding *** results show that all the specimens displayed inferior mechanical properties as compared to the base *** was established that porosity was progressively abridged by the increase of heat *** results also clinched that the use of medium heat input(1-2 kJ/mm)offered the best mechanical properties by eradicating welding defects,in which only about 18.26% of strength was *** yield strength of all the welded specimens remained unaffected indica ted no influence of heat *** melted zone(PMZ)width also affected by heat input,which became widened with the increase of heat *** grain size of PMZ was found to be coarser than the respective grain size in the fusion *** impact testing revealed that the absorbed energy by low heat input specimen(welded at high speed)was greater than that of high heat input(welded at low speed)because of low porosity and the formation of equiaxed grains which induce better impact ***(-196℃)impact testing was also performed and the results corroborate that impact properties under the cryogenic environment revealed no appreciable change after welding at designated heat ***,Macro and micro fractured surfaces of tensile and impact spe

关键词： Tungsten inert gas welding(TIG) Heat input Welding defects Tensile strength Charpy impact strength Micro-vicker hardness SEM

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Tea beverage in chemoprevention and chemotherapy of prostate cancer

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Acta Pharmacologica Sinica 2007年第9期28卷 1392-1408页

作者： Imtiaz A siddiqui mohammad SALEEM Vaqar M ADHAMI mohammad ASIM Hasan MUKHTAR Department of Dermatology University of WisconsinMedical Sciences CenterRoom B-25 1300 University AvenueMadisonWisconsin 53706USA

Prostate cancer (PCa) is the most frequently diagnosed malignancy and the sec-ond leading cause of cancer-related deaths in American males with similar trendsin many western *** existing treatment approaches and surgical inter-vention have not been able to effectively cope with this dreaded *** reasons,it is necessary to intensify our efforts for a better understanding ofthe disease process and for the development of novel approaches for its preven-tion and *** on considerable evidence from in vivo and in vitro dataand epidemiological studies,in recent years the beverage tea has gained consid-erable attention for reducing the risk of several *** of the cancerpreventive effects of tea,especially green tea appear to be mediated by the polyphe-nols present *** evidence suggests that the incidence andoccurrence of PCa is lower in populations that consume tea *** evi-dence suggests that tea polyphenols could be extrapolated to optimize theirchemopreventive properties against *** represents an excellent candidatedisease for chemoprevention because it is typically diagnosed in men over 50years of age and therefore,even a modest delay in neoplastic development achievedthrough pharmacological or nutritional intervention could result in a substantialreduction in the incidence of clinically detectable *** this review weaddress the issue of possible use of tea,especially green tea,for the prevention aswell as treatment of PCa.

关键词： Green tea (-)epigallocatechin-3-gallate (-) epicatechin apoptosis androgen receptor PSA tumor xenograft epidemiology clinical studies

Computer Vision-Control-Based CNN-PID for Mobile Robot

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Computers, Materials & Continua 2021年第7期68卷 1065-1079页

作者： Rihem Farkh mohammad Tabrez Quasim Khaled Al jaloud Saad Alhuwaimel Shams Tabrez siddiqui College of Engineering Muzahimiyah BranchKing Saud UniversityP.O.Box 2454Riyadh11451Saudi Arabia College of Computing and Information Technology University of BishaBisha67714Saudi Arabia King Abdulaziz City for Science and Technology Saudi Arabia Department of Computer Science College of Computer Science and Information TechnologyJazan UniversityJazanSaudi Arabia Department of Electrical Engineering Laboratory for AnalysisConception and Control of SystemsLR-11-ES20National Engineering School of TunisTunis El Manar UniversityTunisTunisia

With the development of artificial intelligence technology,various sectors of industry have *** them,the autonomous vehicle industry has developed considerably,and research on self-driving control systems using artificial intelligence has been extensively *** on the use of image-based deep learning to monitor autonomous driving systems have recently been *** this paper,we propose an advanced control for a serving robot.A serving robot acts as an autonomous line-follower vehicle that can detect and follow the line drawn on the floor and move in specified *** robot should be able to follow the trajectory with speed *** controllers were used simultaneously to achieve *** neural networks(CNNs)are used for target tracking and trajectory prediction,and a proportional-integral-derivative controller is designed for automatic steering and speed *** study makes use of a Raspberry PI,which is responsible for controlling the robot car and performing inference using CNN,based on its current image input.

关键词： Autonomous car pid control deep learning convolutional neural network differential drive system raspberry pi

Early colonoscopy in patients with acute diverticular bleeding is associated with improvement in healthcare-resource utilization

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Gastroenterology Report 2019年第2期7卷 115-120,I0002页

作者： Hamzeh Saraireh Obada Tayyem Mohamed Tausif siddiqui Bashar Hmoud mohammad Bilal Department of Internal Medicine University of Texas Medical BranchGalvestonTXUSA Department of Internal Medicine New York Medical CollegeValhallaNYUSA Division of Gastroenterology&Hepatology Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTXUSA

Background:Diverticular bleeding(DB)is the most common cause of severe acute lower gastrointestinal bleeding(GIB)in developed *** role of early colonoscopy(<24 hours)continues to remain controversial and data on early colonoscopy in acute DB are *** aimed to evaluate the effect of timing of colonoscopy on outcomes in patients with acute DB using a nationwide inpatient ***:Data from the nationwide inpatient sample from 2012 to 2014 were *** ninth version of the International Classification of Diseases coding system ICD 9 was used for patient *** included discharges with the primary and secondary inpatient diagnosis of diverticulosis with bleeding and diverticulitis with *** with no primary or secondary diagnosis of diverticulosis with bleeding,diverticulitis with bleeding,patients who were less than 18 years old and those who did not undergo colonoscopy during the admission were *** primary outcomes were length of stay(LOS)and total hospitalization ***:A total of 88600 patients were included in our analysis,amongstwhom 45020(50.8%)had colonoscopy within 24hours of admission(early colonoscopy),while 43580(49.2%)patients had colonoscopy after 24hours of admission(late colonoscopy).LOS was significantly lower in patients with early colonoscopy as compared to those with late colonoscopy(3.7 vs 5.6days,P<0.0001).Total hospitalization costs were also significantly lower in patients with early colonoscopy($9317 vs$11767,P<0.0001).There was no difference inmortality between both groups(0.7 vs 0.8%).After adjusting for potential confounders,the differences in LOS and total hospitalization costs between early and late colonoscopy remained statistically ***:Early colonoscopy in acute DB significantly reduced LOS and total hospitalization *** was no significant difference inmortality *** of early colonoscopy in the appropriate patients presenting with acute DB

关键词： Diverticular bleeding colonoscopy lower gastrointestinal bleeding timing of colonoscopy

Railway Track Fault Detection Using Mel Frequency Cepstral Coefficient from Acoustic Data using Chi Square

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Chinese Journal of Electronics 2023年

作者： Furqan Rustam Abid Ishaq Muhammad shadab Alam Hashmi Hafeez-Ur-Rehman siddiqui Imran Ashraf Department of Information and Communication Engineering Yeungnam University Faculty of Computer Science and Information Technology Khawaja Fareed University of Engineering and Information Technology School of Computer Science University College Dublin

Spatial, temporal, and weather elements like ballast, loose nuts, misalignment, and cracks due to rain, snow, and earthquakes may lead to railway accidents and cause human and financial loss. Manual inspection is erroneous, labor-intensive, and *** automatic inspection provides a fast, reliable, and unbiased solution in this regard, however, ensuring high accuracy for fault detection is challenging due to the lack of public datasets, noisy data, high computer processing requirements, and inefficient models. This study presents an approach that uses Mel frequency cepstral coefficient features from the acoustic data. The dataset gathered using a customized railway cart from our previous research is used for experiments. The focus of the study is to increase the fault detection performance using selective features from the acoustic data. This study employs Chisquare(Chi2) for the selection of important features and involves performance analysis of machine learning and deep learning models using selected features. Experimental results suggest that using 60 features, 40 original features, and 20 Chi2 features, produces optimal results both regarding accuracy and computational complexity. A 100%accuracy can be obtained using the proposed approach with machine learning models. Moreover, this performance is significantly better than existing approaches.

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