Tea beverage in chemoprevention and chemotherapy of prostate cancer

作     者：Imtiaz A SIDDIQUI Mohammad SALEEM Vaqar M ADHAMI Mohammad ASIM Hasan MUKHTAR 

作者机构：Department of DermatologyUniversity of WisconsinMedical Sciences CenterRoom B-25 1300 University AvenueMadisonWisconsin 53706USA 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2007年第28卷第9期

页      面：1392-1408页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by US PHS Grants(RO1 CA 78809 RO1 CA 101039 RO1 CA 120451) the O'Brian Center Grant(P50 DK065303-01) 

主　　题：Green tea (-)epigallocatechin-3-gallate (-) epicatechin apoptosis androgen receptor PSA tumor xenograft epidemiology clinical studies 

摘      要：Prostate cancer (PCa) is the most frequently diagnosed malignancy and the sec-ond leading cause of cancer-related deaths in American males with similar trendsin many western *** existing treatment approaches and surgical inter-vention have not been able to effectively cope with this dreaded *** reasons,it is necessary to intensify our efforts for a better understanding ofthe disease process and for the development of novel approaches for its preven-tion and *** on considerable evidence from in vivo and in vitro dataand epidemiological studies,in recent years the beverage tea has gained consid-erable attention for reducing the risk of several *** of the cancerpreventive effects of tea,especially green tea appear to be mediated by the polyphe-nols present *** evidence suggests that the incidence andoccurrence of PCa is lower in populations that consume tea *** evi-dence suggests that tea polyphenols could be extrapolated to optimize theirchemopreventive properties against *** represents an excellent candidatedisease for chemoprevention because it is typically diagnosed in men over 50years of age and therefore,even a modest delay in neoplastic development achievedthrough pharmacological or nutritional intervention could result in a substantialreduction in the incidence of clinically detectable *** this review weaddress the issue of possible use of tea,especially green tea,for the prevention aswell as treatment of PCa.