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Inf luence of Spirulina platensis exudates on the endocrine and nervous systems of a mammalian model

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 449-455页

作者： Samah Mamdouh mohamed fathy Ashraf mohamed mohamed Essa Zoology Department Faculty of Science Fayoum University Biology Department Faculty of Science Jazan University Botany Department Faculty of Science Fayoum University

Objective: To investigate the ef ect of intra-peritoneal injection of purii ed exudates of axenic Spirulina platensis on the mammalian endocrine and nervous systems. Methods: The intra-peritoneal injection of the cyanobacterial exudates in mice was applied. Sex hormonal levels of testosterone and progesterone were measured using radioimmunoassay while the follicular stimulating hormone and luteinizing hormone were evaluated by direct chemiluminescence. In addition, superoxide dismutase, catalase and glutathione peroxidase were monitored in the hippocampus region using spectrophotometric method. The levels of the hippocampal monoamines, dopamine, noradrenaline and serotonin were analyzed by high performance liquid chromatography while the acetyl choline neurotransmitter was measured by colorimetric method using choline/acetylcholine assay kit. Results: A sharp disruption in the sex hormones levels of testosterone, progesterone, follicular stimulating hormone and luteinizing hormone was demonstrated in the serum of the treated mice. At the same time, a signii cant reduction in the endogenous antioxidant defense enzymes, superoxide dismutase, catalase and glutathione peroxidase was observed in the hippocampus region of the injected mice. Moreover, levels of dopamine, noradrenaline, serotonin and acetyl choline neurotransmitter in the same region were signii cantly af ected as a result of the treatment with Spirulina i ltrate. The gas chromatography-mass spectrometer and liquid chromatography mass spectrometry/mass spectrometry analysis showed the presence of some sterol-like compounds in the cyanobacterial i ltrate. Conclusions: This study demonstrated the capability of Spirulina to release detrimental bioactive metabolites into their surrounding that can disrupt the mammalian endocrine and nervous systems.

关键词： Spirulina platensis Sterol-like compounds Sex hormones Antioxidant enzymes Neurotransmitters

4-Port Octagonal Shaped MIMO Antenna with Low Mutual Coupling for UWB Applications

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1999-2015页

作者： Mahmoud A.Abdelghany mohamed fathy Abo Sree Arpan Desai Ahmed A.Ibrahim Electrical Engineering Department College of EngineeringPrince Sattam bin Abdulaziz UniversityWadi Addwasir11991Saudi Arabia Electronic and Communication Department Arab Academy for ScienceTechnology and Maritime TransportCairo11865Egypt Department of Electronics and Communication Engineering CSPITCharotar University of Science and Technology(CHARUSAT)Changa388421India Electronics and Communications Engineering Department Minia UniversityEl-Minia61519Egypt

A4-port multiple-input multiple-output(MIMO)antenna exhibiting lowmutual coupling andUWBperformance is *** octagonal-shaped four-antenna elements are connected with a 50microstrip feed line that is arranged rotationally to achieve the orthogonal polarization for improving the MIMO system *** antenna has a wideband impedance bandwidth of 7.5GHz with S11<−10 dB from(103.44%)3.5–11GHz and inter-element isolation higher than 20 *** validation is carried out by verifying the simulated and measured results after fabricating the *** results in the form of omnidirectional radiation patterns,peak gain(≥4 dBi),and Envelope Correlation Coefficient(ECC)(≤0.01)are extracted to validate the suggested antenna ***,time-domain analysis was investigated to demonstrate the operation of the suggested antenna in wideband ***,the simulated and experimental outcomes have almost similar tendenciesmaking the antenna suitable for its use in UWBMIMOapplications.

关键词： MIMO antenna low mutual coupling time domain analysis UWB antenna

Vital Parameters Assessments of Starvation Tolerance of in vitro Populus alba Culture

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Phyton-International Journal of Experimental Botany 2022年第4期91卷 889-902页

作者： mohamed fathy Ahmed Eman Zakaria Ahmed Salman Aloufi Mohammed Alqurashi Amal Alyamani Eman Fayad Eman Tawfik Hussien Horticulture Department Faculty of AgricultureAin Shams UniversityCairo11566Egypt Botany and Microbiology Department Faculty of ScienceHelwan UniversityCairo11795Egypt Department of Biotechnology Faculty of SciencesTaif UniversityTaif21944Saudi Arabia

Populus alba is a large woody deciduous *** plant has been introduced to shooting,then multiplication of rooting on Murashige and Skoog(MS)*** work was designed to estimate the effect of two factors(low levels of 1-Naphthaleneacetic acid NAA and sucrose)on *** response resulting in 6 treatments compared to the control,with twelve measured *** was a significant difference in some measurements in morphology,like plantlets fresh-weight,shoot-,root-length,and leaf *** the physiological measurements,there were significant differences in all the measured *** low concentrations of sucrose and media composition/power(MS grams/L)led to starvation in plants;however,these conditions led to enhancement in some morphological and physiological parameters to overcome the starvation effect,compared to the *** RAPD-PCR molecular marker(four decamers)was used to evaluate the new individuals’genetic variation(instability),resulting in a total polymorphism percentage of 50.83%.It was formerly known that the plantlets were identical to each other and to the mother *** this study,however,the use of distinct media power,hormonal and sucrose levels resulted in molecular variation reflected in ***’s morphological and physiological responses.

关键词： Genetic stability Populus alba RAPD-PCR somaclonal variations starvation

Forehead Flap in Coverage of Nasal Defects: Our Experience

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Modern Plastic Surgery 2020年第1期10卷 1-8页

作者： mohamed Elsayed mohamed mohamed Ahmed fathy mohamed Eldehn Department of Plastic Surgery Ahmed Maher Teaching Hospital Cairo Egypt Department of ENT Kasr Al-Ainy Medical School Cairo Egypt

Background: Coverage of post-traumatic or post-oncosurgical nasal defects is a very challenging procedure. Small nasal defects may be covered by skin grafts or small local flaps while larger nasal defects require more complex flap coverage techniques as using tissue expanders, prefabricated flaps or free flaps. The forehead flap has been used for centuries and remains a workhorse flap for reconstruction of large and complex nasal defects. Aim: evaluate the feasibility and versatility of forehead flap for resurfacing nasal defects. Materials and Methods: 12 patients underwent coverage of nasal defects after trauma or tumor excision using forehead flaps. All flaps needed a second stage for flap separation 3 weeks after the time of operation. The size of the harvested flap, the harvesting time, results of transferred flaps, patient satisfaction and flap-related complications were analyzed. Results: 12 patients (10 males and 2 females) underwent reconstruction of different nasal defects using 12 forehead flaps. The overall complications occurred in 2 patients. The remaining 10 patients showed no complications and passed an uneventful follow-up period. 7 Patients were very satisfied, 4 were satisfied and only one patient was not satisfied as she was 23 years old young female and was subjected to human bite. Follow-up periods ranged from 6 to 12 months. Conclusion: Nasal defects can successfully be managed with the forehead flap. Probably, the flap provides the best result due to the good matching of the skin in terms of color, texture, and thickness. Also, despite the increasing use of free flaps, the forehead flap is still a valid and safe option for nasal defects coverage that allows good aesthetics and functional outcomes.

关键词： Nasal Defects Forehead Flap Flap Coverage Nasal Reconstruction

Impact of biliary complications on quality of life in live-donor liver transplant recipients

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World Journal of Hepatology 2021年第10期13卷 1405-1416页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin Wesam Ahmed Ibrahim Shereen A Saleh mohamed Bahaa Mahmoud El-Meteini mohamed fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman mohamed Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Despite significant advancements in liver transplantation(LT)surgical procedures and perioperative care,post-LT biliary complications(BCs)remain a significant source of morbidity,mortality,and graft *** addition,data are conflicting regarding the health-related quality of life(HRQoL)of LT ***,the success of LT should be considered in terms of both the survival and recovery of *** To assess the impact of BCs on the HRQoL of live-donor LT recipients(LDLT-Rs).METHODS We retrospectively analysed data for 25 LDLT-Rs who developed BCs post-LT between January 2011 and December 2016 at our *** Short Form 12 version 2(SF 12v2)health survey was used to assess their *** also included 25 LDLT-Rs without any post-LT complications as a control *** The scores for HRQoL of LDLT-Rs who developed BCs were significantly higher than the norm-based scores in the domains of physical functioning(P=0.003),role-physical(P<0.001),bodily pain(P=0.003),general health(P=0.004),social functioning(P=0.005),role-emotional(P<0.001),and mental health(P<0.001).No significant difference between the two groups regarding vitality was detected(P=1.000).The LDLT-Rs with BCs had significantly lower scores than LDLT-Rs without BCs in all HRQoL domains(P<0.001)and the mental(P<0.001)and physical(P=0.0002)component summary *** The development of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.

关键词： Live-donor liver transplantation Quality of life The Short Form 12 version 2 Cirrhosis Biliary complications Mental health

Biliary complications in recipients of living donor liver transplantation:A single-centre study

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World Journal of Hepatology 2021年第12期13卷 2081-2103页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin Wesam Ahmed Ibrahim Shereen A Saleh mohamed Bahaa Mahmoud El-Meteini mohamed fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Biliary complications(BCs)after liver transplantation(LT)remain a considerable cause of morbidity,mortality,increased cost,and graft *** To investigate the impact of BCs on chronic graft rejection,graft failure and *** From 2011 to 2016,215 adult recipients underwent right-lobe living-donor liver transplantation(RT-LDLT)at our *** excluded 46 recipients who met the exclusion criteria,and 169 recipients were included in the final ***’and recipients’demographic data,clinical data,operative details and postoperative course information were *** also reviewed the management and outcomes of *** were followed for at least 12 mo post-LT until December 2017 or graft or patient *** The overall incidence rate of BCs including biliary leakage,biliary infection and biliary stricture was 57.4%.Twenty-seven(16%)patients experienced chronic graft *** failure developed in 20(11.8%)patients.A total of 28(16.6%)deaths occurred during *** were a risk factor for the occurrence of chronic graft rejection and failure;however,mortality was determined by recurrent hepatitis C virus *** Biliary complications after RT-LDLT represent an independent risk factor for chronic graft rejection and graft failure;nonetheless,effective management of these complications can improve patient and graft survival.

关键词： Biliary complications Living donor liver transplantation Retrospective analysis Bile leak Biliary stricture Risk factors Mortality Graft rejection

Pharmacist Opportunities to Improve Public Self-Medicating Practices in the UAE

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Pharmacology & Pharmacy 2016年第11期7卷 459-471页

作者： Sanah Hasan Ghazaleh Farghadani Salaa Khalid AlHaideri mohamed Abdelraouf fathy Department of Clinical Pharmacy College of Pharmacy Ajman University of Science and Technology Ajman UAE College of Pharmacy University of Sharjah Sharjah UAE

Objective: Self-treatment is an important aspect of self-care and one of the vital issues under debate in health care. Self-medication patterns vary among different populations and are influenced by many factors. The objective was to investigate the nature of self-medication behavior among the general public in the UAE and to explore public attitudes, beliefs, and level of knowledge concerning self-medication. Methods: A purposive sample of individuals involved in self-medication who belong to different age, gender, income, education level and health-seeking behaviors. A qualitative approach through individual face-to-face interviews was utilized to investigate participants’ behaviors and attitudes towards self-medication;factors influencing decision to self medicate, sources of information on medications, types of conditions for which self-medication is sought and types of medications used. Participant recruitment continued until theme saturation using content analysis. Findings: Three themes emerged from the data: Reasons for self-medication such as costs associated with visiting a doctor, convenience in visiting a pharmacy and perception of simplicity of the condition;Sources of information: pharmacists as a main source in addition to medication leaflets, family role and previous use, and medicines and medicines’ use: medicines’ use in chronic disease, use of antibiotics, use of herbals and supplements and medicines’ use in children. Conclusion: Findings from this study indicate that self-medication behaviors are common among the population due to several reasons. Inappropriate self-medication practices are evident and may compromise patient care outcomes. Pharmacists play a vital role in intervening to optimize the use of medications and patient education regarding self-care.

关键词： Self Medication Minor Ailments Community Pharmacy Qualitative Research United Arab Emirates

Double J Fixation after Craniotomy: Technical Description of a Modification Method for Bone Flap Fixation (Hiederov Method)

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Open Journal of Modern Neurosurgery 2020年第3期10卷 318-324页

作者： Hieder Al-Shami Ahmed M. Salah mohamed fathy Adel Ali Al-Ahly Bank Hospital Cairo Egypt Department of Neurosurgery Faculty of Medicine Kasr-Alainy Medical School Cairo Egypt

Background: Fixation of bone flap following craniotomy is usually achieved by synthetic materials. In rural and poor funding areas, innovation for cheap, safe and applicable material is needed. Purpose: The aim is to assess our new innovative technique in bone flap fixation against traditional techniques. Patients and Methods: The study was a prospective randomized controlled study enrolled at Al-Amal Hospital and Al-Ahly Bank Hospital from 2014-2019. Forty-eight patients were randomized in the study. Group A (24 patients) underwent titanium miniplate fixation while group B (24 patients) underwent our new technique. The new technique is double J tunnels performed by craniotome on either side of the bone (flap and skull sides), then a Prolene suture is passed through the shared stem of J’ holes and secured in the wrapped side of J’s holes and tying it tightly. Both techniques were examined against fixation time, rigidity, offset and final judgment postoperatively. Result: There was no statistically significant difference in using both techniques as regard fixation time. Our new technique was not inferior to the traditional one in achieving rigidity (p > 0.05). The final postoperative assessment was as equal as that seen in miniplate fixation. Conclusion: This technique is a simple, easy, cheap and effective method of fixing craniotomy bone flap.

关键词： Craniotomy Bone Flap Fixation Miniplate Fixation

Theoretical, Experimental and Numerical Investigations of the Effect of Inlet Blade Angle on the Performance of Regenerative Blowers

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Open Journal of Fluid Dynamics 2015年第3期5卷 224-237页

作者： Tarek Abdel-Malak Mekhail Omar mohamed Dahab mohamed fathy Sadik Mahmoud mohamed El-Gendi Hesham Sayed Abdel-Mohsen Faculty of Energy Engineering Mechanical Power Department Aswan University Aswan Egypt Faculty of Engineering Mechanical Power Department Aswan University Aswan Egypt Faculty of Engineering Mechanical Power and Energy Department Minia University Minia Egypt

Regenerative machines allow high heads at small flow rates and present performance curves with very stable features. This research includes a study of the effect of four inlet flow angles (90°, 115°, 125° and 135°) of the blade at outlet flow angle of 90° on the performance of regenerative blower at rotation speed of 3000 rpm and at different flow rates. Investigation and comparison of the experimental results with both one-dimensional theoretical model and numerical CFD technique using CFX-ANSYS 16.1 are done. The numerical CFD analysis show that the flow enters the impeller from the blade side (about 65% of the blade side area) and leaves from the blade tip and blade side (the remaining 35% from the blade side area). According to this observation, a mathematical model that is based on momentum exchange theory to handle one inlet angle and two exit angles for the regenerative blower impeller blades is proposed. Consequently, the experimental work is carried out by two steps. The first step is done by studying the effect of inlet blade angle of 90° and analyzing the results by using the CFD analysis. The CFD results show shock losses and vortices behind each blade at the inlet flow regions. To reduce these losses, an increase of the inlet blade angle in a range between 25° to 45° is proposed. The second step is the splitting of this angle range to three inlet blade angles of 115°, 125° and 135° in order to study and analyze the CFD results for these angels. The CFD analysis shows the disappearance of the shock losses and vortices that are formed behind the blade of angle 90°. The experimental results show that the pressure head and the efficiency depend strongly on the blade inlet and outlet flow angles as well as on the blade geometry. The results also show that the best blower performance can be obtained at an inlet flow angle of 125°, and this is confirmed by CFD simulation analysis. Finally, it is shown that the proposed one-dimensional model yield results that

关键词： Regenerative Blower Circulatory Flow CFD Shock Losses Vortices Impeller Angles