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Alteration of the respiratory microbiome in COVID-19 patients with different severities

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Journal of Genetics and Genomics 2022年第3期49卷 258-261页

作者： Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li mingzhou xie Yangqing Zhan Ye Lin Zhun Li Min xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityNational Center for Respiratory MedicineGuangzhouGuangdong 510120China Department of Computer Sciences City University of Hong KongHong Kong 999077China Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhouGuangdong 510060China Beijing YuanShengKangTai(ProtoDNA)Genetech Co.Ltd. Beijing100190China

Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients.

关键词： patients respiratory clinical

Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China

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Science China(Life Sciences) 2021年第12期64卷 2129-2143页

作者： Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan mingzhou xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Beijing YuanShengKangTai(ProtoDNA)Genetech Co. Ltd.Beijing 100190China Department of Pulmonary and Critical Care Medicine Guangdong Second Provincial General HospitalGuangzhou 510317China Department of Computer Science City University of Hong KongHong Kong 999077China

Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been ***,the clinical outcome and pathogenesis remain *** this study,we recruited 43 laboratory-confirmed COVID-19 *** found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom ***,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies ***,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease *** viral RNA shedding is associated with viral mutations and host factors.

关键词： SRAS-CoV-2 longitudinal virological changes viral genome host gene expression

High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast

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Frontiers of Medicine 2023年第5期17卷 907-923页

作者： Dawei xie Zheng Wang Beibei Sun Liwei Qu Musheng Zeng Lin Feng mingzhou Guo Guizhen Wang Jihui Hao Guangbiao Zhou State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing100101China State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou510060China Department of Gastroenterology&Hepatology and Department of Pathology Chinese People’s Liberation Army General HospitalBeijing100853China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin300060China

The characteristic genetic abnormality of neuroendocrine neoplasms(NENs),a heterogeneous group of tumors found in various organs,remains to be ***,based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase(FAK)in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes,we found that Box 6/Box 7-containing FAK variants(FAK^(6/7))were observed in 7(87.5%)of 8 pancreatic neuroendocrine carcinomas and 20(11.76%)of 170 pancreatic ductal adenocarcinomas(PDACs).We tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumors,and found that FAK^(6/7)was positive in 34(75.6%)of 45 pancreatic NENs,19(47.5%)of 40 pancreatic solid pseudopapillary neoplasms,and 2(2.9%)of 69 *** further tested FAK splicing variants in breast neuroendocrine carcinoma(BrNECs),and found that FAK^(6/7)was positive in 14(93.3%)of 15 BrNECs but 0 in 23 non-NEC breast *** explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix protein 4(SRRM4)was overexpressed in FAK^(6/7)-positive pancreatic tumors and breast tumors,which promoted the formation of FAK^(6/7)in *** results suggested that FAK^(6/7)could be a biomarker of NENs and represent a potential therapeutic target for these orphan diseases.

关键词： FAKFAK^(6/7) SRRM4 neuroendocrine neoplasms pancreas breast SRRM4 neuroendocrine neoplasms pancreas breast

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Secular trends of asthma mortality in China and the United States from 1990 to 2019

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Chinese Medical Journal 2024年第3期137卷 273-282页

作者： Xiaochen Li mingzhou Guo Yang Niu Min xie Xiansheng Liu Department of Pulmonary and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China NHC Key Laboratory of Respiratory Diseases WuhanHubei 430030China

Background:Asthma imposes a large healthcare burden in China and the United States(US).However,the trends of asthma mortality and the relative risk factors have not been comparatively analyzed between the *** aim of this study was to compare the mortality and risk factors between China and the ***:The deaths,and mortality rates of asthma in China and the US during 1990–2019 were obtained from the Global Burden of Disease Study *** age–period–cohort model was used to estimate these mortality rates based on a log-linear scale with additive age,period,and cohort *** population attributable fractions of risk factors for asthma were ***:In 1990–2019,the asthma mortality rate was higher in China than in the *** crude and age-standardized asthma mortality rates trended downward in both China and the US from 1990 to *** decline in mortality was more obvious in *** gap between the two countries was narrowing.A sex difference in asthma mortality was observed with higher mortality in males in China and females in the *** age effects showed that mortality increased with age in adults older than 20 years,particularly in the *** trends were generally observed in the period and cohort rate ratios in both countries,with China experiencing a more obvious *** and high body mass index(BMI)were the leading risk factors for asthma mortality in China and the US,*** attributable to occupational asthmagens and smoking decreased the most in China and the US,***:In 1990–2019,the asthma mortality rate was higher in China than in the US;however,the mortality gap has *** increased with age in *** improvements in asthma death risk with period and birth cohort were more obvious in China than in the ***,high BMI,and aging are major health problems associated with asthma *** role of occupational asthmagens in asthma mortality under

关键词： Asthma Mortality Global disease burden China the United States Age–period–cohort model

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氧化矿添加下铜闪速熔炼过程热力学仿真分析

有色金属(冶炼部分) 2025年第3期 10-20页

作者：冯雨辰李明周道永琪黄金堤谢剑才李俊标江西理工大学冶金工程学院江西赣州341000 金隆铜业有限公司安徽铜陵244021

针对氧化矿添加下铜闪速熔炼过程特性变化不明的难题,采用构建的铜闪速熔炼过程多相平衡热力学模型及计算系统,考察氧化铜精矿添加率和组分含量对主要技术指标、产物组分含量以及过程热量控制等的影响。结果表明,适量添加氧化铜精矿可... 详细信息

针对氧化矿添加下铜闪速熔炼过程特性变化不明的难题,采用构建的铜闪速熔炼过程多相平衡热力学模型及计算系统,考察氧化铜精矿添加率和组分含量对主要技术指标、产物组分含量以及过程热量控制等的影响。结果表明,适量添加氧化铜精矿可有效提升铜锍品位,减少高熔点炉渣生成,但过量添加会导致能耗增加和炉况恶化。综合分析后,建议控制添加率在8%左右,同时入炉添加氧化铜精矿组分含量控制在合适范围,如Cu品位高于25%,FeO含量大于5%,S含量小于0.9%,SiO2含量低于30%,从而确保良好产品质量和主要技术指标。

关键词：氧化矿铜闪速熔炼多相化学平衡热力学仿真 MetCal

Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen xie Yi Zhao mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

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红薯渣不溶性膳食纤维超高压改性

农业工程学报 2012年第19期28卷 270-278页

作者：李雁熊明洲尹丛林吴芳解新安杨公明华南农业大学食品学院广州510640 瑞士万通中国有限公司北京100005

为增强红薯渣膳食纤维的生理功能,研究超高压对其理化性质的影响。该文以红薯渣为原料,采用均匀试验方法对不溶性膳食纤维产品理化性质进行超高压改性,并通过扫描电镜、毛细管电泳法、红外光谱、X射线衍射、比表面积测试法BET和粒度等... 详细信息

为增强红薯渣膳食纤维的生理功能,研究超高压对其理化性质的影响。该文以红薯渣为原料,采用均匀试验方法对不溶性膳食纤维产品理化性质进行超高压改性,并通过扫描电镜、毛细管电泳法、红外光谱、X射线衍射、比表面积测试法BET和粒度等手段研究改性对膳食纤维结构及理化性质的影响。结果表明:超高压改性不溶性膳食纤维的工艺条件如压力、时间、温度对其调节血糖、血脂、清除外源有害物质能力有显著影响。得出超高压对调节血糖、血脂能力改性条件:600MPa,15min,60℃;清除外源有害物质改性条件:100MPa,10min,42℃。通过对改性膳食纤维结构、理化性质测定发现,改性红薯渣不溶性膳食纤维的微观结构为疏松、光滑、蜂巢形的多孔网状结构;其单糖组分没有太大影响,单糖含量产生了一定程度的变化;改性使结晶度减小,比表面积增大;特征吸收峰增强、红移和蓝移,同时也产生了一些新的吸收峰。研究结果可为红薯渣膳食纤维的功能改性及综合利用提供相关依据。

关键词：压力物理特性化学特性红薯渣膳食纤维改性超高压

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淀粉微球形成过程的介观模拟及实验

化学学报 2011年第2期69卷 169-175页

作者：解新安丁年平刘焕彬郑璐丝熊明洲华南农业大学食品学院广州510642 华南理工大学轻工与食品学院广州510642

以环己烷为油相、淀粉乳液为水相、Span60和Tween60为乳化剂,对淀粉微球的形成过程进行了耗散粒子动力学(DPD)模拟及实验研究.模拟结果表明,淀粉微球的形成过程存在四个阶段,即淀粉与乳化剂分子无规则分散阶段、小聚集体形成阶段、球状... 详细信息

以环己烷为油相、淀粉乳液为水相、Span60和Tween60为乳化剂,对淀粉微球的形成过程进行了耗散粒子动力学(DPD)模拟及实验研究.模拟结果表明,淀粉微球的形成过程存在四个阶段,即淀粉与乳化剂分子无规则分散阶段、小聚集体形成阶段、球状聚集体形成阶段和稳定平衡阶段,并且发现油水比是影响聚集体是否能形成球状的关键因素.油水比小于7的条件下,油水两相分离较难,水相呈现片状、十字型状、柱状及椭球状等形状;当油水比增加到8,水相能形成微球且微球粒径随油水比增加而减小.同时实验结果表明,油水比为8时,微球粘连,几乎看不清球状形貌,油水比为10～20时,微球的粒径随油水比的增大而减小.实验结果很好地吻合了模拟结果.

关键词：淀粉微球介观模拟耗散粒子动力学(DPD)

复杂地质条件下浅埋暗挖地铁车站施工期地面沉降量FLAC^(3D)分析

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岩石力学与工程学报 2006年第z2期25卷 4254-4260页

作者：白明洲许兆义时静张爱军雷军谢晋水北京交通大学土木建筑工程学院北京100044

浅埋暗挖地铁车站施工期地面沉降量对施工安全具有重要意义。北京地铁10号线苏州街车站为多套地层力学性质差异较大的复杂场地,根据地质勘察结果的地层三维空间分布状况,建立车站场地的三维地质模型;应用试验结果确定各类土层的物理力... 详细信息

浅埋暗挖地铁车站施工期地面沉降量对施工安全具有重要意义。北京地铁10号线苏州街车站为多套地层力学性质差异较大的复杂场地,根据地质勘察结果的地层三维空间分布状况,建立车站场地的三维地质模型;应用试验结果确定各类土层的物理力学参数;依据工程设计方案,概化洞桩法施工过程为6个施工步序;采用等效模拟的方法概化超前地层预加固;应用FLAC3D计算软件,优化开挖施工方案,模拟动态施工过程,分析各施工步序暗挖车站周围土体的变形量和地面沉降量;研究确定引起最大地面沉降量的施工步序。通过现已完成施工的导洞开挖步序施工变形监测结果与计算结果比较分析,验证计算结果的可靠性,根据计算结果预测地铁车站施工期的最终地面沉降量。

关键词：隧道工程三维地层分布地铁车站地面沉降量数值模拟